VEGF signaling: Role in angiogenesis and beyond

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(2), С. 189079 - 189079

Опубликована: Янв. 26, 2024

Язык: Английский

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Exosomal circRNAs: Novel biomarkers and therapeutic targets for urinary tumors

Cancer Letters, Год журнала: 2024, Номер 588, С. 216759 - 216759

Опубликована: Фев. 28, 2024

Язык: Английский

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Overcoming cancer therapy resistance: From drug innovation to therapeutics

Drug Resistance Updates, Год журнала: 2025, Номер 81, С. 101229 - 101229

Опубликована: Март 8, 2025

Язык: Английский

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The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond

Drug Resistance Updates, Год журнала: 2024, Номер 73, С. 101062 - 101062

Опубликована: Янв. 29, 2024

Язык: Английский

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Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Molecules, Год журнала: 2023, Номер 28(19), С. 6902 - 6902

Опубликована: Окт. 1, 2023

Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. It has been widely studied for its potential neuroprotective anticancer agent. This review aims to critically evaluate the current evidence supporting effects of SFN mechanisms through which it exerts these effects. shown exert activation Nrf2 pathway, modulation neuroinflammation, epigenetic mechanisms. In cancer treatment, demonstrated ability selectively induce cell death cells, inhibit histone deacetylase, sensitize cells chemotherapy. also chemoprotective properties inhibiting phase I metabolizing enzymes, modulating II xenobiotic-metabolizing targeting stem cells. addition therapeutic agent neurological disorders promise treatment cerebral ischemic injury intracranial hemorrhage. Finally, ongoing completed clinical trials on suggest benefits, but more research needed establish effectiveness. Overall, holds significant natural with diverse applications.

Язык: Английский

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Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties

RSC Advances, Год журнала: 2024, Номер 14(9), С. 5690 - 5728

Опубликована: Янв. 1, 2024

VEGF, an important category of tyrosine kinases, and its receptors (VEGFR) are hyper-activated in different cancers. The recently reported indolyl analogs with potential antineoplastic VEGFR inhibitory properties highlighted.

Язык: Английский

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The roles of hyaluronan in kidney development, physiology and disease

Nature Reviews Nephrology, Год журнала: 2024, Номер 20(12), С. 822 - 832

Опубликована: Авг. 27, 2024

Язык: Английский

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The roles of ERIANIN in tumor and innate immunity and its’ perspectives in immunotherapy

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Апрель 28, 2023

Traditional Chinese medicine has been used in China for thousands of years. In 2022, the 14th Five-Year Plan Development Medicine was released, aiming to enhance traditional health services and improve policies systems high-quality medicinal development by 2025. ERIANIN, main component Dendrobium, plays an important role anti-inflammatory, antiviral, antitumor, antiangiogenic, other pharmacological effects. ERIANIN broad-spectrum antitumor effects, its tumor-suppressive effects have confirmed study various diseases, such as precancerous lesions stomach, gastric cancer, liver lung prostate bladder breast cervical osteosarcoma, colorectal leukaemia, nasopharyngeal cancer melanoma through multiple signaling pathways. Thus, aim this review systematically summarise research on with serving a reference future compound briefly discuss some perspectives combined immunotherapy.

Язык: Английский

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Virtual Screening, Molecular Docking Studies and DFT Calculations of Novel Anticancer Flavonoids as Potential VEGFR-2 Inhibitors

Chemistry Africa, Год журнала: 2023, Номер 6(4), С. 1847 - 1861

Опубликована: Фев. 25, 2023

Язык: Английский

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Targeting vascular normalization: a promising strategy to improve immune–vascular crosstalk in cancer immunotherapy

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Дек. 15, 2023

Blood vessels are a key target for cancer therapy. Compared with the healthy vasculature, tumor blood extremely immature, highly permeable, and deficient in pericytes. The aberrantly vascularized microenvironment is characterized by hypoxia, low pH, high interstitial pressure, immunosuppression. efficacy of chemotherapy, radiotherapy, immunotherapy affected abnormal vessels. Some anti-angiogenic drugs show vascular normalization effects addition to targeting angiogenesis. Reversing state creates normal microenvironment, essential various treatments, specifically immunotherapy. In addition, immune cells molecules involved regulation Therefore, combining may increase reduce risk adverse reactions. this review, we discussed structure, function, formation elaborated on role immunosuppressive Finally, described clinical challenges associated combination normalization, highlighted future research directions therapeutic area.

Язык: Английский

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