VEGF signaling: Role in angiogenesis and beyond

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(2), P. 189079 - 189079

Published: Jan. 26, 2024

Language: Английский

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Exosomal circRNAs: Novel biomarkers and therapeutic targets for urinary tumors

Cancer Letters, Journal Year: 2024, Volume and Issue: 588, P. 216759 - 216759

Published: Feb. 28, 2024

Language: Английский

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Overcoming cancer therapy resistance: From drug innovation to therapeutics

Drug Resistance Updates, Journal Year: 2025, Volume and Issue: 81, P. 101229 - 101229

Published: March 8, 2025

Language: Английский

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The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 73, P. 101062 - 101062

Published: Jan. 29, 2024

Language: Английский

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Sulforaphane’s Multifaceted Potential: From Neuroprotection to Anticancer Action

Molecules, Journal Year: 2023, Volume and Issue: 28(19), P. 6902 - 6902

Published: Oct. 1, 2023

Sulforaphane (SFN) is a naturally occurring compound found in cruciferous vegetables such as broccoli and cauliflower. It has been widely studied for its potential neuroprotective anticancer agent. This review aims to critically evaluate the current evidence supporting effects of SFN mechanisms through which it exerts these effects. shown exert activation Nrf2 pathway, modulation neuroinflammation, epigenetic mechanisms. In cancer treatment, demonstrated ability selectively induce cell death cells, inhibit histone deacetylase, sensitize cells chemotherapy. also chemoprotective properties inhibiting phase I metabolizing enzymes, modulating II xenobiotic-metabolizing targeting stem cells. addition therapeutic agent neurological disorders promise treatment cerebral ischemic injury intracranial hemorrhage. Finally, ongoing completed clinical trials on suggest benefits, but more research needed establish effectiveness. Overall, holds significant natural with diverse applications.

Language: Английский

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Antineoplastic indole-containing compounds with potential VEGFR inhibitory properties

RSC Advances, Journal Year: 2024, Volume and Issue: 14(9), P. 5690 - 5728

Published: Jan. 1, 2024

VEGF, an important category of tyrosine kinases, and its receptors (VEGFR) are hyper-activated in different cancers. The recently reported indolyl analogs with potential antineoplastic VEGFR inhibitory properties highlighted.

Language: Английский

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The roles of hyaluronan in kidney development, physiology and disease

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: 20(12), P. 822 - 832

Published: Aug. 27, 2024

Language: Английский

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The roles of ERIANIN in tumor and innate immunity and its’ perspectives in immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: April 28, 2023

Traditional Chinese medicine has been used in China for thousands of years. In 2022, the 14th Five-Year Plan Development Medicine was released, aiming to enhance traditional health services and improve policies systems high-quality medicinal development by 2025. ERIANIN, main component Dendrobium, plays an important role anti-inflammatory, antiviral, antitumor, antiangiogenic, other pharmacological effects. ERIANIN broad-spectrum antitumor effects, its tumor-suppressive effects have confirmed study various diseases, such as precancerous lesions stomach, gastric cancer, liver lung prostate bladder breast cervical osteosarcoma, colorectal leukaemia, nasopharyngeal cancer melanoma through multiple signaling pathways. Thus, aim this review systematically summarise research on with serving a reference future compound briefly discuss some perspectives combined immunotherapy.

Language: Английский

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Virtual Screening, Molecular Docking Studies and DFT Calculations of Novel Anticancer Flavonoids as Potential VEGFR-2 Inhibitors

Chemistry Africa, Journal Year: 2023, Volume and Issue: 6(4), P. 1847 - 1861

Published: Feb. 25, 2023

Language: Английский

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Targeting vascular normalization: a promising strategy to improve immune–vascular crosstalk in cancer immunotherapy

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 15, 2023

Blood vessels are a key target for cancer therapy. Compared with the healthy vasculature, tumor blood extremely immature, highly permeable, and deficient in pericytes. The aberrantly vascularized microenvironment is characterized by hypoxia, low pH, high interstitial pressure, immunosuppression. efficacy of chemotherapy, radiotherapy, immunotherapy affected abnormal vessels. Some anti-angiogenic drugs show vascular normalization effects addition to targeting angiogenesis. Reversing state creates normal microenvironment, essential various treatments, specifically immunotherapy. In addition, immune cells molecules involved regulation Therefore, combining may increase reduce risk adverse reactions. this review, we discussed structure, function, formation elaborated on role immunosuppressive Finally, described clinical challenges associated combination normalization, highlighted future research directions therapeutic area.

Language: Английский

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