Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and Approaches to Resolve It

Molecules, Год журнала: 2020, Номер 25(6), С. 1340 - 1340

Опубликована: Март 16, 2020

Antimicrobial resistance represents an enormous global health crisis and one of the most serious threats humans face today. Some bacterial strains have acquired to nearly all antibiotics. Therefore, new antibacterial agents are crucially needed overcome resistant bacteria. In 2017, World Health Organization (WHO) has published a list antibiotic-resistant priority pathogens, pathogens which present great threat antibiotics urgently is categorized according urgency need for as critical, high, medium priority, in order guide promote research development The majority WHO Gram-negative pathogens. Due their distinctive structure, bacteria more than Gram-positive bacteria, cause significant morbidity mortality worldwide. Several strategies been reported fight control like antimicrobial auxiliary agents, structural modification existing antibiotics, into study chemical structures with mechanisms action novel targets that sensitive to. Research efforts made meet urgent treatments; some succeeded yield activity against by deactivating mechanism resistance, β-lactamase Inhibitor antibiotic adjuvants. Another promising trend was referring nature develop naturally derived on targets, such bacteriophages, DCAP(2-((3-(3,6-dichloro-9H-carbazol-9-yl)-2-hydroxypropyl)amino)-2(hydroxymethyl)propane1,3-diol, Odilorhabdins (ODLs), peptidic benzimidazoles, quorum sensing (QS) inhibitors, metal-based agents.

Язык: Английский

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Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection

Antimicrobial Agents and Chemotherapy, Год журнала: 2017, Номер 61(10)

Опубликована: Авг. 15, 2017

ABSTRACT Widespread antibiotic use in clinical medicine and the livestock industry has contributed to global spread of multidrug-resistant (MDR) bacterial pathogens, including Acinetobacter baumannii . We report on a method used produce personalized bacteriophage-based therapeutic treatment for 68-year-old diabetic patient with necrotizing pancreatitis complicated by an MDR A. infection. Despite multiple courses efforts at percutaneous drainage pancreatic pseudocyst, deteriorated over 4-month period. In absence effective antibiotics, two laboratories identified nine different bacteriophages lytic activity isolate from patient. Administration these intravenously percutaneously into abscess cavities was associated reversal patient's downward trajectory, clearance infection, return health. The outcome this case suggests that methods described here production bacteriophage therapeutics could be applied similar cases more concerted investigate infections are warranted.

Язык: Английский

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Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria

Cell Host & Microbe, Год журнала: 2019, Номер 25(2), С. 219 - 232

Опубликована: Фев. 1, 2019

Язык: Английский

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Phage therapy: An alternative to antibiotics in the age of multi-drug resistance

World Journal of Gastrointestinal Pharmacology and Therapeutics, Год журнала: 2017, Номер 8(3), С. 162 - 162

Опубликована: Янв. 1, 2017

The practice of phage therapy, which uses bacterial viruses (phages) to treat infections, has been around for almost a century.The universal decline in the effectiveness antibiotics generated renewed interest revisiting this practice.Conventionally, therapy relies on use naturally-occurring phages infect and lyse bacteria at site infection.Biotechnological advances have further expanded repertoire potential therapeutics include novel strategies using bioengineered purified lytic proteins.Current research their proteins, specifically against multidrugresistant suggests be used as either an alternative or supplement antibiotic treatments.Antibacterial therapies, whether phage-or antibiotic-based, each relative advantages disadvantages; accordingly, many considerations must taken into account when designing therapeutic approaches preventing treating infections.Although much is still unknown about interactions between phage, bacteria, human host, time take seriously seems rapidly approaching.

Язык: Английский

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Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease

Nature, Год журнала: 2019, Номер 575(7783), С. 505 - 511

Опубликована: Ноя. 13, 2019

Язык: Английский

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Formulation, stabilisation and encapsulation of bacteriophage for phage therapy

Advances in Colloid and Interface Science, Год журнала: 2017, Номер 249, С. 100 - 133

Опубликована: Май 14, 2017

Язык: Английский

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Adherent-invasive Escherichia coli in inflammatory bowel disease

Gut, Год журнала: 2017, Номер 67(3), С. 574 - 587

Опубликована: Ноя. 15, 2017

Intestinal microbiome dysbiosis has been consistently described in patients with IBD. In the last decades, Escherichia coli , and adherent-invasive E (AIEC) pathotype particular, implicated pathogenesis of Since discovery AIEC, two decades ago, progress made unravelling these bacteria characteristics its interaction gut immune system. The mechanisms adhesion AIEC to intestinal epithelial cells (via FimH cell molecule 6) ability escape autophagy when inside macrophages are reviewed here. We also explore existing data on prevalence Crohn’s disease UC, association between presence location, activity postoperative recurrence. Finally, we highlight potential therapeutic strategies targeting colonisation mucosa, including use phage therapy, bacteriocins antiadhesive molecules. These may open new avenues for prevention treatment IBD future.

Язык: Английский

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Synergy between the Host Immune System and Bacteriophage Is Essential for Successful Phage Therapy against an Acute Respiratory Pathogen

Cell Host & Microbe, Год журнала: 2017, Номер 22(1), С. 38 - 47.e4

Опубликована: Июль 1, 2017

Язык: Английский

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Advantages and Limitations of Bacteriophages for the Treatment of Bacterial Infections

Frontiers in Pharmacology, Год журнала: 2019, Номер 10

Опубликована: Май 8, 2019

Bacteriophages (BPs) are viruses that can infect and kill bacteria without any negative effect on human or animal cells. For this reason, it is supposed they be used, alone in combination with antibiotics, to treat bacterial infections. In narrative review, the advantages limitations of BPs for use humans will discussed. PubMed was used search all studies published from January 2008 December 2018 using key words: “bacteriophages” “phages” “bacterial infection” “antibiotic” “infectious diseases”. More than 100 articles were found, but only those English providing evidence-based data included evaluation. Literature review showed rapid rise multi-drug-resistant worldwide coupled a decline development production novel antibacterial agents have led scientists consider treatment infection. Use overcome problem increasing resistance antibiotics attractive, some research seem indicate might rational measure. However, present knowledge seems insufficient allow purpose. To date, how prepare formulations clinical avoid limit risk emergence through transmission genetic material not completely solved problems. Further specifically devoted solve these problems needed before humans.

Язык: Английский

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Phage therapy: From biological mechanisms to future directions

Cell, Год журнала: 2023, Номер 186(1), С. 17 - 31

Опубликована: Янв. 1, 2023

Increasing antimicrobial resistance rates have revitalized bacteriophage (phage) research, the natural predators of bacteria discovered over 100 years ago. In order to use phages therapeutically, they should (1) preferably be lytic, (2) kill bacterial host efficiently, and (3) fully characterized exclude side effects. Developing therapeutic takes a coordinated effort multiple stakeholders. Herein, we review state art in phage therapy, covering biological mechanisms, clinical applications, remaining challenges, future directions involving naturally occurring genetically modified or synthetic phages.

Язык: Английский

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