The bidirectional interaction of COVID-19 infections and lipoproteins

Best Practice & Research Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 37(4), С. 101751 - 101751

Опубликована: Фев. 24, 2023

COVID-19 infections decrease total cholesterol, LDL-C, HDL-C, and apolipoprotein A-I, A-II, B levels while triglyceride may be increased or inappropriately normal for the poor nutritional status. The degree of reduction in A-I are predictive mortality. With recovery lipid/lipoprotein return towards pre-infection studies have even suggested an risk dyslipidemia post-COVID-19 infection. potential mechanisms these changes lipid lipoprotein discussed. Decreased HDL-C measured many years prior to associated with severe B, Lp (a), were not consistently risk. Finally, data suggest that omega-3-fatty acids PCSK9 inhibitors reduce severity infections. Thus, alter affect developing

Язык: Английский

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Association between lipid profile and clinical outcomes in COVID-19 patients

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Май 27, 2024

Abstract High-density lipoprotein cholesterol (HDL-c) removes cholesterol, an essential component in lipid rafts, and this removal can regulate protein attachment to modulating their functionality the immune cell response. Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection alter profile, there is little information on role of HDL-c other lipids prognostic disease 2019 (COVID-19) Mexican population. This study aims evaluate predictive value profile severity survival 102 patients infected with SARS-CoV-2 during COVID-19 first wave. Our findings, derived from univariate multivariate Cox proportional hazards regression models, highlighted age hypertension as significant predictors (HR = 1.04, p 0.012; HR 2.78, 0.027), while gender, diabetes, obesity showed no impact. Triglycerides levels notably influenced mortality, elevated triglycerides lower associated higher mortality risk (p 0.032). underscores importance profiles alongside traditional factors assessing outcomes. It contributes understanding patient management emphasizes need for further investigation into dyslipidemia influencing prognosis, potentially aiding refined stratification therapeutic strategies.

Язык: Английский

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Pathogenic mechanisms of cardiovascular damage in COVID-19

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Июнь 19, 2024

Abstract Background COVID-19 is a new infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Since outbreak in December 2019, it has an unprecedented world pandemic, leading to global human health crisis. Although SARS CoV-2 mainly affects lungs, causing interstitial pneumonia and distress syndrome, number of patients often have extensive clinical manifestations, such as gastrointestinal symptoms, cardiovascular damage renal dysfunction. Purpose This review article discusses pathogenic mechanisms provides some useful suggestions for future diagnosis, treatment prevention. Methods An English-language literature search was conducted PubMed Web Science databases up 12th April, 2024 terms “COVID-19”, “SARS CoV-2”, “cardiovascular damage”, “myocardial injury”, “myocarditis”, “hypertension”, “arrhythmia”, “heart failure” “coronary heart disease”, especially update articles 2023 2024. Salient medical literatures regarding were selected, extracted synthesized. Results The most common myocarditis pericarditis, hypertension, arrhythmia, myocardial injury failure, coronary disease, stress cardiomyopathy, ischemic stroke, blood coagulation abnormalities, dyslipidemia. Two important may be direct viral cytotoxicity well indirect hyperimmune responses body infection. Conclusions Cardiovascular portends worse prognosis. underlying pathophysiological related are not completely clear, two SARSCoV-2 infection responses.

Язык: Английский

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HDL-based therapeutics: A promising frontier in combating viral and bacterial infections

Pharmacology & Therapeutics, Год журнала: 2024, Номер 260, С. 108684 - 108684

Опубликована: Июль 2, 2024

Язык: Английский

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High density lipoproteins and COVID-19: preparing the next pandemic

Journal of Lipid Research, Год журнала: 2025, Номер unknown, С. 100779 - 100779

Опубликована: Март 1, 2025

High-density lipoproteins (HDLs) are heterogeneous particles with pleiotropic functions including anti-inflammatory and anti-infectious effects. In clinical studies, lower HDL-associated cholesterol (HDL-C) concentration has been associated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, severity mortality. A reduction in the number of HDL particles, particularly small ones observed alterations their protein lipid composition impairing functions. These observations have supported supplementation promising results preliminary studies. This review summarizes available evidence on these different aspects to better understand two-way interaction between HDLs Coronavirus disease 2019 (COVID-19) guiding future HDL-based therapies for preparing next pandemic.

Язык: Английский

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Cholesterol, triglycerides, HDL, and nitric oxide as determinants of resting heart rate variability in non-hospitalized mild post-COVID individuals: a cross-sectional study

BMC Cardiovascular Disorders, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 31, 2025

Abstract Background The association between plasma lipids, nitric oxide (NO) and cardiovascular risk has been well documented in the literature, however, these outcomes heart rate variability (HRV) COVID-19 remains incipient as there is no scientific evidence that investigated this outcome. Objective Investigate whether metabolic may be associated with cardiac autonomic behavior arising from short-term HRV variables non-hospitalized mild post-COVID individuals. Methods This a cross-sectional study. Individuals of both sexes, aged ≥ 18 years, who tested positive for SARS-CoV-2 according to RT-PCR test, without need hospitalization, were included. was collected supine position at least 10 min later analysis Kubios software. Metabolic [high density lipoprotein (HDL) (mg/dL), cholesterol triglycerides (mg/dL) NO (µmol/L)] through blood sample. Results Seventy-three individuals included (post-COVID = 32; control 41). worse group when compared ( p < 0.05). Cholesterol, HDL, showed significant correlations indices. Regression models indicated triglycerides, NO, explain up 30.3% variations certain indices, suggesting an impact on modulation. Conclusion There relationship COVID-19. are 16.6% 30.30% resting Clinical trial number Not applicable.

Язык: Английский

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A cross-sectional study of laboratory parameters 5-6 months after the first COVID-19 infection

Heliyon, Год журнала: 2025, Номер 11(4), С. e42535 - e42535

Опубликована: Фев. 1, 2025

Highlights:•Most laboratory parameters returned to reference values 6 months after COVID-19 infection•Values of certain still correlated with severity•Values suggest incomplete resolution renal, biliary tract, and immune system functionAbstractObjectivesDespite extensive study disease, only a few studies also addressed the aftermath disease potential long-term consequences. The aim this was assess through cross-sectional analysis an range haematological biochemical find markers associated severity 5-6-months post infection.MethodsIn study, we analysed 92 routine biochemical, immunological in 75 non-vaccinated patients 5-6 recorded first time SARS-CoV-2 infection without reinfection. Demographic data were obtained surveys.ResultsThe majority within normal intervals, however, statistically significant correlations detected 15 parameters: B lymphocytes, NK cells, interleukin (IL)-12, IL-1β, cortisol, ferritin, specific IgG IgM antibodies, Na, Cl, creatinine, alkaline phosphatase, cholesterol, HbA1c alpha 2 beta globulin fractions proteinogram.ConclusionsAlthough most observed their severity, that could indicate either pre-infection baseline state which affected outcome or minor remaining alterations function organs, pertaining stress damage during acute phase disease.Graphical abstract

Язык: Английский

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Association of Mediterranean Diet with Cardiovascular Risk Factors and with Metabolic Syndrome in Subjects with Long COVID: BioICOPER Study

Nutrients, Год журнала: 2025, Номер 17(4), С. 656 - 656

Опубликована: Фев. 12, 2025

Long COVID has been associated with increased cardiovascular risk and chronic low-grade inflammation, raising concerns about its long-term metabolic consequences. Given that the Mediterranean diet (MD) shown beneficial effects on factors inflammation in various populations, it is important to explore potential impact individuals COVID. Therefore, aim determine association of MD (CVRF) syndrome (MetS) Caucasian subjects diagnosed Cross-sectional study, 305 were included following WHO criteria. Adherence was evaluated MEDAS (Mediterranean Diet Screener) 14 items used Prevention study (PREDIMED study). The criteria considered diagnose MetS blood pressure, glycemia, triglycerides, HDL cholesterol, waist circumference. Other CVRFs tobacco consumption, total LDL body mass index, baseline uric acid levels. between CVRF number components analyzed using multiple regression models multinomial regression. mean age 52.75 ± 11.94 years (men 55.74 12.22 women 51.33 11.57; p = 0.002), (68% women). questionnaire 7.76 2.37. presented 23.6% (39.8% men 15.9% < 0.001). In analysis, after adjusting for average time from acute COVID-19 infection date inclusion this score showed a negative (β -0.295; 95% CI: -0.496 -0.093), BMI -0.049; -0.096 -0.002), -0.210; -0.410 -0.010), circumference (WC) -0.021; -0.037 -0.003) positive cholesterol -0.018; 0.001 -0.037). findings suggest higher scores are lower levels acid, fewer components, smaller circumference,

Язык: Английский

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COVID-19 and neuropathy in type 2 diabetes

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 1, 2025

Язык: Английский

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Ketogenic Diet and Ketone Bodies as Clinical Support for the Treatment of SARS-CoV-2—Review of the Evidence

Viruses, Год журнала: 2023, Номер 15(6), С. 1262 - 1262

Опубликована: Май 27, 2023

One of the proposed nutritional therapies to support drug therapy in COVID-19 is use a ketogenic diet (KD) or ketone bodies. In this review, we summarized evidence from tissue, animal, and human models looked at mechanisms action KD/ketone bodies against COVID-19. were shown be effective stage virus entry into host cell. The β-hydroxybutyrate (BHB), by preventing metabolic reprogramming associated with infection improving mitochondrial function, reduced glycolysis CD4+ lymphocytes improved respiratory chain could provide an alternative carbon source for oxidative phosphorylation (OXPHOS). Through multiple mechanisms, supported immune response. animal models, KD resulted protection weight loss hypoxemia, faster recovery, lung injury, better survival young mice. humans, increased survival, need hospitalization COVID-19, showed protective role abnormalities after It appears that may considered as clinical intervention assist treatment despite fact numerous studies indicate SARS-CoV-2 alone induce ketoacidosis. However, such requires strong scientific validation.

Язык: Английский

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