Natural Product Communications,
Год журнала:
2024,
Номер
19(12)
Опубликована: Дек. 1, 2024
The
present
study
is
aimed
to
explore
the
therapeutic
attributes
of
diosgenin
against
atherosclerosis
and
associated
health
disorder.
Side
effects
with
synthetic
drugs
for
treatment
management
diseases
worldwide
have
necessitated
scientists
investigate
evaluate
potential
phytochemicals
their
pharmacological
activities.
Plants
including
Smilax
China,
Dioscorea
alata,
Trigonella
foenum
graecum
are
rich
sources
diosgenin.
In
addition
being
a
crucial
component
in
creation
several
steroidal
medications,
this
bioactive
phytochemical
has
shown
great
promise
wide
range
diseases,
cancer,
hypercholesterolemia,
inflammation,
multiple
infections.
Diosgenin
can
reduce
hyperlipidemia
by
lowering
amount
low-density
lipoproteins,
interfering
absorption
cholesterol
increasing
its
excretion.
inhibits
expression
NPCIL1
receptor,
LXR-alpha,
HMG
CoA
SRB1,
increases
ABC
G5/G8
transporters
prevent
dietary
accumulation
body.
exhibits
antithrombotic
activity
inhibiting
platelet
activation,
modulating
anti
coagulation
significantly
decreasing
factor
Viii
activity.
oxidation
LDLs,
hence
preventing
atherosclerosis.
It
also
possesses
pancreatic
lipase
provides
anti-inflammatory
benefits
human
inflammatory
markers
Interlukin-1
beta
(IL-1β),
Tumor
necrosis
–
alpha
(TNF-α),
Nitric
Oxide
cytokines.
Moreover,
it
promotes
synthesis
antioxidant
enzymes
such
as
glutathione
peroxidase
superoxide
dismutase.
By
modifying
IKKβ
pathway,
reduces
endothelial
damage
linked
insulin
resistance.
This
review
discusses
recent
advancements
reducing
atherosclerotic
cardiovascular
diabetes,
clinical
application,
pharmacokinetics
underlying
mechanism
existing
scientific
evidences.
BMC Cardiovascular Disorders,
Год журнала:
2024,
Номер
24(1)
Опубликована: Июль 30, 2024
Abstract
Objective
To
examine
the
influences
and
mechanisms
of
MicroRNA-19a-3p
(miR-19a-3p)
on
endothelial
dysfunction
in
atherosclerosis.
Methods
An
analysis
miR-19a
expression
was
carried
out
using
Gene
Expression
Omnibus
(GEO)
database.
The
effect
miR-19a-3p
function
HUVECs
evaluated
by
overexpression
under
TNF-α
treatment.
Luciferase
assays
were
performed
to
explore
potential
target
genes.
Overexpression
junctional
protein
associated
with
coronary
artery
disease
(JCAD)
used
effects
cell
adhesion,
proliferation.
Results
MiR-19a-3p
cells
decreased
after
exposure
and/or
oscillatory
flow,
consistent
change
found
atherosclerotic
plaques.
Additionally,
inflammation
significantly
diminished
but
markedly
exacerbated
inhibition.
transfection
JCAD
binding
3’-UTR
mRNA.
Furthermore,
protective
against
achieved
regulating
closely
linked
Hippo/YAP
signaling
pathway.
Conclusion
is
a
crucial
molecular
switch
onset
atherosclerosis
possible
pharmacological
therapeutic
strategy
for
reversing
development
Biomolecules,
Год журнала:
2025,
Номер
15(2), С. 201 - 201
Опубликована: Янв. 31, 2025
Acute
and
chronic
coronary
artery
disease
(CAD)
are
interconnected,
representing
two
facets
of
the
same
condition.
Chronic
CAD
exhibits
a
dynamic
nature,
manifesting
as
stable
or
acute
ischemia,
both.
Myocardial
ischemia
can
be
transient
reversible.
The
genesis
involves
diverse
anatomical
functional
mechanisms,
including
endothelial
dysfunction,
arteriolar
remodeling,
capillary
rarefaction,
perivascular
fibrosis,
though
no
single
factor
explains
its
heterogeneity.
is
often
but
may
present
symptomatic
asymptomatic
(e.g.,
in
diabetes)
affect
various
compartments
(epicardial
microcirculation).
This
complexity
necessitates
reappraisal
our
approach,
pathophysiological
mechanisms
vary
overlap.
A
comprehensive
exploration
these
using
advanced
diagnostic
techniques
aid
identifying
processes
underlying
CAD.
obstructive
non-obstructive,
unstable,
underscoring
diversity.
primary
source
lies
arterial
wall,
emphasizing
need
for
research
on
components,
such
endothelium
vascular
smooth
muscle
cells,
factors
disrupting
homeostasis.
Shifting
focus
from
luminal
status
to
wall
provide
insights
into
atheromatous
plaques,
enabling
earlier
interventions
prevent
their
development
progression.
iScience,
Год журнала:
2024,
Номер
27(6), С. 109849 - 109849
Опубликована: Апрель 27, 2024
Highlights•TUDCA
alleviated
atherosclerosis
and
promoted
cholesterol
efflux
capacity
of
macrophages•TUDCA
inhibited
activation
the
PERK/eIF2α/ATF4
AIM2
inflammasome•ATF4
affected
transcriptional
activity
AIM2•AIM2
mediated
foam
cell
formation
by
targeting
ABCA1SummaryCholesterol
(CEC)
dysfunction
in
macrophages
is
important
atherosclerosis.
However,
mechanism
underlying
CEC
remains
unclear.
We
described
characteristics
ATF4
inflammasome
during
through
scRNA
sequencing
analysis.
Then
model
hyperlipemia
was
established
ApoE−/−
mice;
some
were
treated
with
tauroursodeoxycholic
acid
(TUDCA).
TUDCA
decreased
ATF4,
Hspa,
activation,
reduced
plaque
area
artery,
macrophages.
Furthermore,
abolished
oxLDL-induced
inhibiting
Further
assays
revealed
binding
to
promoter,
promoting
its
significantly.
we
discovered
that
AIM2-mediated
ABCA1,
which
could
be
blocked
TUDCA.
Our
study
demonstrated
alleviates
enhancing
macrophage,
provided
possibilities
for
development
therapies.Graphical
abstract
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 29, 2024
The
topic
of
human
circadian
rhythms
is
not
only
attracting
the
attention
clinical
researchers
from
various
fields
but
also
sparking
a
growing
public
interest.
system
comprises
central
clock,
located
in
suprachiasmatic
nucleus
hypothalamus,
and
peripheral
clocks
tissues
that
are
interconnected;
together
they
coordinate
many
daily
activities,
including
sleep
wakefulness,
physical
activity,
food
intake,
glucose
sensitivity
cardiovascular
functions.
Disruption
regulation
seems
to
be
associated
with
metabolic
disorders
(particularly
impaired
tolerance)
disease.
Previous
trials
revealed
disturbance
system,
specifically
due
shift
work,
an
increased
risk
type
2
diabetes
mellitus.
This
review
intended
provide
clinicians
who
wish
implement
knowledge
disruption
diagnosis
strategies
avoid
cardio-metabolic
disease
general
overview
this
topic.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Май 17, 2024
Background
Cardiovascular
disease
(CVD)
poses
a
significant
global
health
and
economic
challenge,
with
atherosclerosis
being
primary
cause.
Over
the
past
40
years,
substantial
research
has
been
conducted
into
prevention
reversal
of
atherosclerosis,
resulting
in
development
lipid-lowering
agents
such
as
statins
fibrates.
Despite
extensive
literature
formulation
numerous
therapeutic
guidelines
this
domain,
comprehensive
bibliometric
analysis
current
landscape
trends
not
performed.
This
study
aimed
to
elucidate
evolution
milestones
treatments
for
coronary
heart
(CHD)
conjunction
hyperlipidemia
through
analysis,
offering
insights
future
directions
treatment
strategies.
Methods
examined
publications
from
1986
2023
retrieved
Web
Science
database
(Core
Collection).
Utilizing
tools
VOSviewer,
Pajek,
CiteSpace,
we
analyzed
publication
citation
numbers,
H-indexes,
contributions
by
countries
institutions,
authorship,
journal
sources,
keyword
usage
uncover
trajectories
areas
focus.
Results
Our
587
revealed
recent
surge
output,
particularly
post-2003.
The
American
Journal
Cardiology
published
highest
number
studies,
articles,
whereas
Circulation
received
citations
(6,266).
Key
contributors
included
United
States,
Japan,
China,
States
leading
numbers
H-index.
Harvard
University
Leiden
emerged
pivotal
Professors
J.
Wouter
Jukema
Robert
P.
Giugliano
were
identified
experts.
Keyword
disclosed
five
thematic
clusters,
indicating
shift
towards
new
drug
combinations
strategies,
signaling
directions.
Conclusion
last
4
decades
have
seen
notable
rise
on
therapies
CHD
hyperlipidemia,
retaining
world-leading
status.
increase
international
collaboration
aids
innovative
approaches.
PCSK9
inhibitors
combination
therapies,
including
antisense
oligonucleotides
angiopoietin-like
protein
3
inhibitors,
provide
avenues
research,
intending
maximize
safety
efficacy
