Persistence in risk and effect of COVID-19 vaccination on long-term health consequences after SARS-CoV-2 infection

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 26, 2024

Abstract The persisting risk of long-term health consequences SARS-CoV-2 infection and the protection against such conferred by COVID-19 vaccination remains unclear. Here we conducted a retrospective territory-wide cohort study on 1,175,277 patients with stratified their status non-infected controls to evaluate clinical sequelae, cardiovascular all-cause mortality using public healthcare database population-based records in Hong Kong. A progressive reduction was observed over one year between controls. Patients complete or have received booster dose incurred lower including major diseases, than unvaccinated incomplete 30-90 days after infection. Completely vaccinated vaccines did not incur significant higher from 271 91 onwards, respectively, whilst un-vaccinated incompletely continued greater sequelae for up following This provided real-world evidence supporting effectiveness reducing its persistence

Язык: Английский

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Impact of Pre-Infection COVID-19 Vaccination on the Incidence and Severity of Post-COVID Syndrome: A Systematic Review and Meta-Analysis

Vaccines, Год журнала: 2024, Номер 12(2), С. 189 - 189

Опубликована: Фев. 12, 2024

This systematic review critically evaluated the impact of a pre-infection COVID-19 vaccination on incidence and severity post-COVID-19 syndrome aimed to assess potential protective effect across different vaccines patient demographics. study hypothesized that before infection substantially reduces risk syndrome. In October 2023, comprehensive literature search was conducted three databases, PubMed, Embase, Scopus, focusing studies published up date. Utilizing wide array keywords, strategy adhered PRISMA guidelines registered in Open Science Framework. The inclusion criteria comprised patients with breakthrough SARS-CoV-2 who developed We included total 13 articles met criteria, analyzing more than 10 million mean age 50.6 years, showing intensive care unit (ICU) admissions post-vaccination as low 2.4%, significant reduction mortality (OR 0.66, 95% CI 0.58–0.74). prevalence symptoms lower vaccinated individuals (9.5%) compared unvaccinated (14.6%), notable decrease activity-limiting (adjusted OR 0.59, 0.48–0.73). Vaccinated also showed quicker recovery return work (HR 1.37, 1.04–1.79). pooled odds ratio 0.77 indicates is associated 23% developing (95% 0.75–0.79). Despite effects observed, substantial heterogeneity among noted. conclusion, However, observed suggests need for further research standardized methods fully comprehend vaccine efficacy against long COVID.

Язык: Английский

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Association of nirmatrelvir–ritonavir with post-acute sequelae and mortality in patients admitted to hospital with COVID-19: a retrospective cohort study

The Lancet Infectious Diseases, Год журнала: 2024, Номер 24(10), С. 1130 - 1140

Опубликована: Май 3, 2024

Studies have established the short-term efficacy of nirmatrelvir-ritonavir in managing COVID-19, yet its effect on post-COVID-19 condition, especially patients admitted to hospital, remains understudied. This study aimed examine condition among hospital Hong Kong.

Язык: Английский

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Long-term risks of respiratory diseases in patients infected with SARS-CoV-2: a longitudinal, population-based cohort study

EClinicalMedicine, Год журнала: 2024, Номер 69, С. 102500 - 102500

Опубликована: Фев. 17, 2024

BackgroundIn the post-pandemic era, growing apprehension exists regarding potential sequelae of COVID-19. However, risks respiratory diseases following SARS-CoV-2 infection have not been comprehensively understood. This study aimed to investigate whether COVID-19 increases long-term risk illness in patients with COVID-19.MethodsIn this longitudinal, population-based cohort study, we built three distinct cohorts age 37–73 years using UK Biobank database; a group diagnosed medical records between January 30th, 2020 and October 2022, two control groups, contemporary historical group, cutoff dates 2022 2019, respectively. The follow-up period all groups was 2.7 (the median (IQR) time 0.8 years). Respiratory outcomes included common chronic pulmonary (asthma, bronchiectasis, obstructive disease (COPD), interstitial lung (ILD), vascular (PVD), cancer. For data analysis, calculated hazard ratios (HRs) along their 95% CIs Cox regression models, application inverse probability weights (IPTW).FindingsA total 3 were study; 112,311 individuals mean (±SDs) 56.2 (8.1) years, 359,671 370,979 group. Compared those infected exhibited elevated for developing diseases. includes asthma, HR 1.49 CI 1.28–1.74; bronchiectasis (1.30; 1.06–1.61); COPD (1.59; 1.41–1.81); ILD (1.81; 1.38–2.21); PVD 1.39–1.82); cancer (1.39; 1.13–1.71). With severity acute phase COVID-19, pre-described progressively. Besides, during 24-months follow-up, observed an increasing trend asthma over time. Additionally, 0–6 month 3.07 (CI 1.73–5.44), association disappeared at 6–12 (1.06; 0.43–2.64) 12–24 months (1.02; 0.45–2.34). one infection, reinfected higher (3.0; 1.32–6.84), (3.07; 1.42–6.65), (3.61; 1.11–11.8), (3.20; 1.59–6.45). Similar findings noted when comparing serving as including (1.31; 1.13–1.52); (1.53; 1.23–1.89); (1.41; 1.24–1.59); (2.53; 2.05–3.13); (2.30; 1.98–2.66); (2.23; 1.78–2.79).InterpretationOur research suggests that may increased diseases, reinfection. Even 24-month continued increase. Hence, implementing appropriate strategies these is crucial monitor manage health issues. probably due diagnostic tests conducted incidental diagnoses.FundingThe National Natural Science Foundation China Regional Innovation Development Joint Foundation; China; Program High-level Foreign Expert Introduction Distinguished Young Scholars Guangdong Province; Basic Applied Research Climbing Introduced Talents Hospital Construction Project Provincial People's Hospital; VA Clinical Merit ASGE clinical funds.

Язык: Английский

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Differential decline of SARS‐CoV‐2‐specific antibody levels, innate and adaptive immune cells, and shift of Th1/inflammatory to Th2 serum cytokine levels long after first COVID‐19

Allergy, Год журнала: 2024, Номер 79(9), С. 2482 - 2501

Опубликована: Июль 14, 2024

SARS-CoV-2 has triggered a pandemic and contributes to long-lasting morbidity. Several studies have investigated immediate cellular humoral immune responses during acute infection. However, little is known about long-term effects of COVID-19 on the system.

Язык: Английский

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Risk of incident atrial fibrillation after COVID-19 infection: A systematic review and meta-analysis

Heart Rhythm, Год журнала: 2024, Номер 21(9), С. 1613 - 1620

Опубликована: Апрель 17, 2024

Язык: Английский

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Modifiable lifestyle factors and the risk of post-COVID-19 multisystem sequelae, hospitalization, and death

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июль 29, 2024

Abstract Effective prevention strategies for post-COVID complications are crucial patients, clinicians, and policy makers to mitigate their cumulative burden. This study evaluated the association of modifiable lifestyle factors (smoking, alcohol intake, BMI, physical activity, sedentary time, sleep duration, dietary habits) with COVID-19 multisystem sequelae, death, hospitalization in UK Biobank cohort ( n = 68,896). A favorable (6-10 healthy factors; 46.4%) was associated a 36% lower risk sequelae (HR, 0.64; 95% CI, 0.58-0.69; ARR at 210 days, 7.08%; 5.98-8.09) compared an unfavorable (0-4 12.3%). Risk reductions spanned all 10 organ systems, including cardiovascular, coagulation, metabolic, gastrointestinal, kidney, mental health, musculoskeletal, respiratory disorders, fatigue. beneficial effect largely attributable direct impacts independent corresponding pre-infection comorbidities (71% any sequelae). also related death (HR 0.59, 0.52-0.66) 0.78, 0.73-0.84). These associations persisted across acute post-acute infection phases, irrespective status, vaccination, or SARS-CoV-2 variant. findings underscore clinical public health importance adhering mitigating long-term adverse enhancing future pandemic preparedness.

Язык: Английский

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Cardiovascular disease risk after a SARS-CoV-2 infection: A systematic review and meta-analysis

Journal of Infection, Год журнала: 2024, Номер 89(3), С. 106215 - 106215

Опубликована: Июль 4, 2024

To our knowledge, there is no systematic review examining CVD risks after a SARS-CoV-2 infection over time, while also taking into account disease severity. All evidence on the risk for pulmonary embolism (PE), myocardial infarction (MI), ischaemic stroke (IS), haemorrhagic (HS), and arterial thrombosis following was evaluated.

Язык: Английский

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Visualization of Early RNA Replication Kinetics of SARS-CoV-2 by Using Single Molecule RNA-FISH Combined with Immunofluorescence

Viruses, Год журнала: 2024, Номер 16(2), С. 262 - 262

Опубликована: Фев. 7, 2024

SARS-CoV-2 infection remains a global burden. Despite intensive research, the mechanism and dynamics of early viral replication are not completely understood, such as kinetics formation genomic RNA (gRNA), sub-genomic (sgRNA), centers/organelles (ROs). We employed single-molecule RNA-fluorescence in situ hybridization (smRNA-FISH) to simultaneously detect gRNA sgRNA immunofluorescence nsp3 protein, marker for RO, carried out time-course analysis. found that single molecules visible within cytoplasm at 30 min post (p.i.). Starting from 2 h p.i., most existed clusters/speckles, some which were surrounded by sgRNA. These speckles associated with protein starting 3 indicating these precursors ROs. Furthermore, was asynchronous, cells all stages any given time point. Our probes detected variants concern, also suggested BA.1 strain exhibited slower rate than WA1 strain. results provide insights into post-entry events, will facilitate identification new therapeutic targets early-stage combat COVID-19.

Язык: Английский

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Long-term cardiovascular, cerebrovascular, and thrombotic complications after SARS-CoV-2-Omicron infection: a retrospective cohort study

Clinical Microbiology and Infection, Год журнала: 2024, Номер 30(10), С. 1319 - 1326

Опубликована: Июнь 21, 2024

Язык: Английский

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