International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
22(1), С. 45 - 45
Опубликована: Дек. 31, 2024
The
indiscriminate
use
of
plastic
products
and
their
inappropriate
management
disposal
contribute
to
the
increasing
presence
accumulation
this
material
in
all
environmental
zones.
chemical
properties
plastics
resistance
natural
degradation
lead
over
time
production
microplastics
(MPs)
nanoplastics,
which
are
dispersed
soil,
water,
air
can
be
absorbed
by
plants,
including
those
grown
for
food.
In
agriculture,
MPs
come
from
many
sources
(mulch
film,
tractor
tires,
compost,
fertilizers,
pesticides).
possible
effects
type
pollution
on
living
organisms,
especially
humans,
increase
need
carry
out
studies
assess
occupational
exposure
agriculture.
It
would
also
desirable
promote
alternative
materials
sustainable
agronomic
practices
protect
safety
health
agricultural
workers.
The Science of The Total Environment,
Год журнала:
2024,
Номер
926, С. 171819 - 171819
Опубликована: Март 19, 2024
Phthalates
are
ubiquitous
environmental
endocrine
disruptors.
As
the
predominant
phthalate,
di-2-ethylhexyl
phthalate
(DEHP)
has
been
considered
possibly
carcinogenic
to
humans
but
large-scale
longitudinal
evidence
is
needed
further
clarify
its
carcinogenicity.
To
examine
association
between
DEHP
exposure
and
incidence
of
breast
malignant
neoplasm,
carcinoma
in
situ
benign
neoplasm.
A
total
273,295
women
from
UK
Biobank
cohort
were
followed
up
for
a
median
13.5
years.
Disease
information
was
collected
National
Health
Service
Cancer
Registry
Death
Index.
Baseline
yearly-average
level
estimated
each
individual
by
linking
chemical
monitoring
record
European
Environment
Agency
with
home
address
participants
Kriging
interpolation
model.
Cox
proportional
hazard
model
employed
estimate
neoplasms.
The
(IQR)
baseline
concentration
8000.25
(interquartile
range:
6657.85–11,948.83)
1819.93–11,359.55)
μg/L.
highest
quartile
associated
1.11
fold
risk
(95
%
CI,
1.00,
1.23,
p
<
0.001)
1.27
neoplasm
1.05,
1.54,
0.001).
exposure,
positively
higher
(HR,
1.05;
95
1.03,
1.07,
0.001),
1.08;
1.04,
1.11,
1.13;
1.20,
Stratification
analyses
showed
no
significant
modification
effect
on
DEHP-neoplasm
relationship
menopausal
status
or
ethnicity
suggestive
younger
those
who
underwent
oral
contraceptive
pill
therapy.
In
sensitivity
analysis,
associations
remained
when
excluding
cases
diagnosed
within
2
years
post
baseline.
Real-world
Because
health
risks
DEHP,
release
environment
should
be
managed.
Journal of Neuroinflammation,
Год журнала:
2025,
Номер
22(1)
Опубликована: Фев. 7, 2025
Mitochondrial
dysfunction
is
a
pivotal
instigator
of
neuroinflammation,
with
mitochondrial
DNA
(mtDNA)
leakage
as
critical
intermediary.
This
review
delineates
the
intricate
pathways
leading
to
mtDNA
release,
which
include
membrane
permeabilization,
vesicular
trafficking,
disruption
homeostatic
regulation,
and
abnormalities
in
dynamics.
The
escaped
activates
cytosolic
sensors,
especially
cyclic
gmp-amp
synthase
(cGAS)
signalling
inflammasome,
initiating
neuroinflammatory
cascades
via
pathways,
exacerbating
spectrum
neurological
pathologies.
therapeutic
promise
targeting
discussed
detail,
underscoring
necessity
for
multifaceted
strategy
that
encompasses
preservation
homeostasis,
prevention
leakage,
reestablishment
dynamics,
inhibition
activation
sensors.
Advancing
our
understanding
complex
interplay
between
neuroinflammation
imperative
developing
precision
interventions
disorders.
Journal of Hazardous Materials,
Год журнала:
2025,
Номер
unknown, С. 137795 - 137795
Опубликована: Март 1, 2025
Microplastics
(MPs)
and
nanoplastics
(NPs)
represent
an
emerging
issue
for
human
animal
health.
This
review
critically
examines
in
vitro
vivo
studies
to
elucidate
their
mechanisms
of
action
toxicological
effects.
Key
objectives
included:
providing
a
comprehensive
overview
MP-NPs
literature,
assessing
experimental
conditions
relative
real
environmental
scenarios,
identifying
pathways
at
the
molecular
level.
The
findings
revealed
significant
progress
understanding
impacts.
In
particular,
it
has
been
observed
promotion
inflammation,
oxidative
stress,
apoptosis,
autophagy,
endoplasmic
reticulum
(ER)
stress
via
specific
signaling
axes.
Reproductive
toxicity
emerged
as
primary
research
focus,
particularly
male
models,
whereas
effects
on
gastrointestinal,
neurological,
cardiovascular
systems
were
insufficiently
studied,
especially
affected.
Most
disproportionately
focused
polystyrene
particles,
neglecting
other
prevalent
polymers
such
polyethylene
polypropylene.
Furthermore,
reliance
synthetic
microspheres
non-realistic
concentrations
limits
relevance
real-world
conditions.
Limited
long-term
exposure
further
constrain
persistence
risks.
view
this,
future
should
integrate
environmentally
relevant
particles
doses,
size
composition,
assessments,
advanced
methodologies
omics
computational
modeling.
addition,
therapeutic
interventions
targeting
ER
inflammation
apoptosis
may
be
excellent
solution
mitigate
toxicity.
At
same
time,
standardized
global
approach
is
needed
fully
understand
risks
posed
by
MP-NPs,
attempting
safeguard
public
