The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories

JAMA Oncology, Год журнала: 2023, Номер 9(10), С. 1401 - 1401

Опубликована: Сен. 7, 2023

Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, a comprehensive evaluation of their globally, regionally, nationally is crucial for effective policy planning.

Язык: Английский

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Human Papillomavirus–Associated Oropharyngeal Cancer: Review of Current Evidence and Management

Current Oncology, Год журнала: 2019, Номер 26(2), С. 119 - 123

Опубликована: Апрель 1, 2019

Oropharyngeal cancer (opc) has become the leading site for human papillomavirus (hpv)-associated cancers in humans. It is an epidemic that remains relatively unfamiliar to most physicians, potentially delaying diagnosis and treatment. Traditionally, involving head neck have occurred smokers those with a significant alcohol history. Typically, hpv-positive opc presents younger, healthier population different set of risk factors good prognosis survival. However, many head-and-neck patients, including disease, develop lifelong disabilities because morbid nature their treatments, patients highest level unmet needs studies spanning sites. Knowledge this epidemic, high index suspicion, understanding how tumours present clinical practice can help physicians make early diagnosis, thus sparing patient morbidity from treatments associated more advanced disease stages. Furthermore, recognizing these distinct psychosocial implementing collaborative team approach critical providing optimal care improving quality life survivorship period.

Язык: Английский

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European white paper: oropharyngeal dysphagia in head and neck cancer

European Archives of Oto-Rhino-Laryngology, Год журнала: 2020, Номер 278(2), С. 577 - 616

Опубликована: Дек. 19, 2020

To develop a European White Paper document on oropharyngeal dysphagia (OD) in head and neck cancer (HNC). There are wide variations the management of OD associated with HNC across Europe.

Язык: Английский

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Patients’ quality of life during active cancer treatment: a qualitative study

BMC Cancer, Год журнала: 2018, Номер 18(1)

Опубликована: Окт. 4, 2018

Patients' quality of life has become a major objective care in oncology. At the same time, it object increasing interest by researchers, working with both quantitative and qualitative methods. Progress oncology enabled more patients to survive longer, so that cancer is increasingly often chronic disease requires long-term treatment can have negative effects on patients' daily life. Nonetheless, no study explored what report affects their during period. This intended fill this gap.We conducted multicenter based 30 semi-structured interviews. Participants, purposively selected until data saturation, had diverse types started at least 6 months before interview. Data were examined thematic analysis.Our analysis found two themes: (1) negatively affected for patient's period, question which responded talking only about side treatment; (2) positively period three sub-themes: (i) The having -investing - support be defined as an object, relationship or activity particularly invested makes them feel good its bearable, (ii)The subjective perception efficacy antitumor (iii) positive relationships, friends family, also physician.Patients must involved if they are able bear course find ways endure difficult experience care. represents important therapeutic lever used oncologists. They should interested objects, order investment help maintain throughout health pathway. Furthermore, showing topic, patient, could improve physician-patient relation without using up very much physician's time.

Язык: Английский

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Safety and Efficacy of Mesenchymal Stem Cells for Radiation-Induced Xerostomia: A Randomized, Placebo-Controlled Phase 1/2 Trial (MESRIX)

International Journal of Radiation Oncology*Biology*Physics, Год журнала: 2018, Номер 101(3), С. 581 - 592

Опубликована: Март 5, 2018

Язык: Английский

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Variations in HPV function are associated with survival in squamous cell carcinoma

JCI Insight, Год журнала: 2019, Номер 4(1)

Опубликована: Янв. 10, 2019

Incidence of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) has been increasing dramatically. Although long-term survival rates for these patients are high, they often suffer from permanent radiotherapy-related morbidity. This prompted the development de-escalation clinical protocols to reduce However, a subset do not respond even standard therapy and have poor outcomes. It is unclear how properly identify treat high- low-risk OPSCC patients. Since HPV positivity drives radiotherapy sensitivity, we hypothesized that variations in biology may cause differences treatment response outcome. By analyzing gene expression data, identified HPV-related molecules among OPSCC. A tumors presented molecular profile distinct typical exhibited response, indicating similarities with HPV– tumors. These changes were also observed vitro correlated radiation sensitivity. Finally, developed prognostic biomarker signature identification this subgroup validated it independent cohorts cervical carcinomas. findings could translate improved patient stratification deintensification new therapeutic approaches treatment-resistant cancer.

Язык: Английский

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The Key Differences between Human Papillomavirus-Positive and -Negative Head and Neck Cancers: Biological and Clinical Implications

Cancers, Год журнала: 2021, Номер 13(20), С. 5206 - 5206

Опубликована: Окт. 17, 2021

Head and neck squamous cell carcinoma (HNSCC) is a unique malignancy associated with two distinct risk factors: exposure to typical carcinogens infection of human papillomavirus (HPV). HPV encodes the potent oncoproteins E6 E7, which bypass many important oncogenic processes result in cancer development. In contrast, HPV-negative HNSCC developed through multiple mutations diverse driver genes. While factors HPV-positive HNSCCs are discrete, patients still show highly complex molecular signatures, immune infiltrations, treatment responses even within same anatomical subtypes. Here, we summarize current understanding biological mechanisms, approaches, clinical outcomes comparison between -negative HNSCCs.

Язык: Английский

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European Head and Neck Society recommendations for head and neck cancer survivorship care

Oral Oncology, Год журнала: 2022, Номер 133, С. 106047 - 106047

Опубликована: Авг. 3, 2022

Язык: Английский

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Therapeutic Vaccination for HPV-Mediated Cancers

Current Otorhinolaryngology Reports, Год журнала: 2023, Номер 11(1), С. 44 - 61

Опубликована: Фев. 1, 2023

Язык: Английский

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Screening for human papillomavirus‐driven oropharyngeal cancer: Considerations for feasibility and strategies for research

Cancer, Год журнала: 2018, Номер 124(9), С. 1859 - 1866

Опубликована: Март 2, 2018

The incidence and burden of human papillomavirus (HPV)‐driven oropharyngeal cancer is expected to increase for decades, thus motivating discussions regarding possibilities screening. This article addresses issues related the validity timeliness screening HPV‐driven cancer, raises important questions, highlights deficits confusion in existing literature, proposes needed steps research agenda.

Язык: Английский

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