Polymers,
Год журнала:
2023,
Номер
15(12), С. 2638 - 2638
Опубликована: Июнь 9, 2023
As
a
Food
and
Drug
Administration
(FDA)-approved
molecular-targeted
chemotherapeutic
drug,
sorafenib
(SF)
can
inhibit
angiogenesis
tumor
cell
proliferation,
leading
to
improved
patient
overall
survival
of
hepatocellular
carcinoma
(HCC).
In
addition,
SF
is
an
oral
multikinase
inhibitor
as
single-agent
therapy
in
renal
carcinoma.
However,
the
poor
aqueous
solubility,
low
bioavailability,
unfavorable
pharmacokinetic
properties
undesirable
side
effects
(anorexia,
gastrointestinal
bleeding,
severe
skin
toxicity,
etc.)
seriously
limit
its
clinical
application.
To
overcome
these
drawbacks,
entrapment
into
nanocarriers
by
nanoformulations
effective
strategy,
which
delivers
target
with
decreased
adverse
treatment
efficacy.
this
review,
significant
advances
design
strategies
nanodelivery
systems
from
2012
2023
are
summarized.
The
review
organized
type
carriers
including
natural
biomacromolecule
(lipid,
chitosan,
cyclodextrin,
etc.);
synthetic
polymer
(poly(lactic-co-glycolic
acid),
polyethyleneimine,
brush
copolymer,
mesoporous
silica;
gold
nanoparticles;
others.
Co-delivery
other
active
agents
(glypican-3,
hyaluronic
acid,
apolipoprotein
peptide,
folate,
superparamagnetic
iron
oxide
nanoparticles)
for
targeted
nanosystems
synergistic
drug
combinations
also
highlighted.
All
studies
showed
promising
results
HCC
cancers
SF-based
nanomedicines.
outlook,
challenges
future
opportunities
development
delivery
presented.
Turkish Journal of Pharmaceutical Sciences,
Год журнала:
2025,
Номер
21(6), С. 551 - 556
Опубликована: Янв. 10, 2025
Objectives:
Variations
in
the
types
and
quantities
of
excipients
used
to
prepare
liposomes
can
affect
physicochemical
properties
liposome
formulations.This
study
aimed
provide
information
about
design
fabrication
5-fluorouracil
(5-FU)-loaded
formulations
using
different
lipid
cholesterol
(CHOL)
derivatives.Materials
Methods:
Passive
loading
via
a
small-volume
incubation
method
was
liposomes.The
particle
size,
polydispersity
index,
zeta
potential,
encapsulation
efficiency
(EE%)
were
determined.The
release
studies
conducted
Franz
diffusion
cell
at
37
°C.In
this
study,
high-pressure
liquid
chromatography
device
measure
amount
5-FU.Results:
The
mean
sizes
all
between
134
166
nm,
they
had
negative
charge
on
their
surface.Increasing
cholesteryl
hemisuccinate
content
reduced
size
liposomes.Additionally,
exhibited
low
index
(0.3).The
EE%
exceeded
30%.The
vitro
5-FU
from
followed
Korsemeyer-Peppas
model.
Conclusion:Modifying
CHOL
formulations,
as
indicated
by
experimental
results,
change
characteristic
use
soybean
phosphatidylcholine
appears
be
promising
combination
for
preparation
hydrophilic
drug-loaded
formulations.
Hybrid Advances,
Год журнала:
2024,
Номер
5, С. 100139 - 100139
Опубликована: Янв. 1, 2024
Nanotechnology,
rather
than
traditional
medicinal
procedures
like
chemotherapy,
now
helps
to
reduce
adverse
effects.
There
is
a
great
demand
for
biocompatible
nanocarrier
with
long
half-life,
high
bioavailability,
and
capable
of
imaging
cells
targeting
them
selectively.
A
procedure
known
as
water-in-oil-in-water
(W/O/W)
emulsification
was
employed
produce
hybrid
nanohydrogels
containing
agarose,
polyvinyl
alcohol,
halloysite
nanotubes,
5-fluorouracil
(AGA-PVA-HNT@5-Fu)
which
can
be
highly
effective
decreasing
the
particle
size
improving
their
uniformity.
These
hydrogels
were
produced
specifically
target
administer
5-Fu
anti-cancer
drug
treatment
breast
cancer.
Following
evaluation
physicochemical
characteristics,
both
substantial
loading
efficient
trapping
accomplished.
The
displayed
zeta
potential
−38.4
mV
indicative
good
stability
due
usage
span
80.
Based
on
release
profile
conducted
in
vitro,
it
observed
that
AGA-PVA-HNT@5-Fu
released
medication
regulated
way.
By
using
MTT
flow
cytometry
analysis,
found
could
effectively
eliminate
tumor
cells,
while
blank
nanoparticles
proved
biocompatible.
results
indicate
based
utilized
treating
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
8, С. 100281 - 100281
Опубликована: Авг. 28, 2024
Cancer
is
the
leading
cause
of
death
globally,
and
conventional
treatments
have
limited
efficacy
with
severe
side
effects.
The
use
nanotechnology
has
potential
to
reduce
effects
drugs
by
creating
efficient
controlled
anticancer
drug
delivery
systems.
Nanoparticles
(NPs)
used
as
carriers
offer
several
advantages,
including
enhanced
protection,
biodistribution,
selectivity
and,
pharmacokinetics.
Therefore,
this
review
devoted
various
organic
(lipid,
polymeric)
well
inorganic
nanoparticles
based
on
different
building
units
providing
a
wide
range
potent
Within
these
nanoparticulate
systems,
chitosan
(CS)-based
NPs
are
discussed
particular
emphasis
due
unique
properties
CS
its
derivatives
non-toxicity,
biodegradability,
mucoadhesivity,
tunable
physico-chemical
biological
allowing
their
alteration
specifically
target
cancer
cells.
In
context
streamlining
systems
(DDS),
innovative
nanoplatform-based
therapy
pathways
involving
passive
active
targeting
stimuli-responsive
DDS
enhancing
overall
orthogonality
developed
NP-DDS
towards
included.
most
up-to-date
information
delivering
anti-cancer
using
modern
dosage
forms
specifically,
CSNPs,
summarised
evaluated
concerning
benefits,
limitations,
advanced
applications.
Inorganic Chemistry Communications,
Год журнала:
2024,
Номер
162, С. 112180 - 112180
Опубликована: Фев. 10, 2024
Breast
cancer
is
a
significant
issue
for
women
globally,
and
conventional
treatments
have
limitations
in
controlling
the
disease.
Thus,
it
crucial
to
design
effective
platforms
precise,
tailored
targeted
drug
delivery.
For
such
purpose,
novel
polyvinyl
alcohol-polyvinylpyrrolidone-montmorillonite
(PVA-PVP-MMT)
nanocomposite
with
ratio
of
1:2:1
(w/v%)
has
been
designed
herein
delivery
doxorubicin
(Dox)
as
model
MCF-7
breast
cells.
The
characterized
by
different
analytical
techniques,
including
FT-IR,
XRD,
DLS,
FE-SEM.
DLS
zeta
potential
measurements
revealed
an
average
hydrodynamic
diameter
402
nm
nanocarrier
surface
charge
42
mV,
respectively.
According
FE-SEM
analysis,
its
size
ranges
from
200
340
shows
semi-spherical
step-like
morphologies.
Drug
release
data
pH-sensitive
(22
%
37
pH
7.4
5.4
within
6
h,
respectively)
controlled
manner
(about
50
48
h).
Biomedical
tests,
MTT
apoptosis,
were
carried
out
study
cell
suppression
efficiency
PVA-PVP-Dox-MMT.
assay
indicated
cytotoxicity
after
24
h
treatment
nanocarrier,
flow
cytometry
demonstrated
40
apoptosis.
results
this
support
that
developed
PVA-PVP-Dox-MMT
platform
very
promising
candidate
treatment.
ADMET & DMPK,
Год журнала:
2025,
Номер
unknown, С. 2554 - 2554
Опубликована: Янв. 3, 2025
Despite
significant
advancements
in
cancer
therapies,
chemotherapeutics
continue
to
be
the
mainstay
for
treating
patients,
with
5-fluorouracil
(5-FU)
being
commonly
used
various
cancers.
However,
its
limited
ability
penetrate
cell
membranes
and
short
half-life,
caused
by
rapid
metabolism,
necessitate
frequent
administration
of
high
doses
maintain
effective
therapeutic
levels.
This
study
aimed
synthesize
oxidized
sodium
alginate
(OSA)
derivatives
create
OSA
nanoparticles
loaded
5-FU
(OSANP@
5-FU),
promoting
diketo
tautomers,
evaluate
their
photophysical
properties,
release
profile,
anticancer
activity
minimal
toxicity.
The
investigation
encompassed
physicochemical
characterization,
encapsulation
efficiency,
kinetics
at
pH
2.2
7.4,
viability
assessment
via
MTT
assay
V79
cells,
vitro
efficacy
A375
line.
Steady-state
absorption
emission
confirmed
presence
advantageous
diketone
tautomers
5-FU,
indicating
radiative
transitions
from
second
singlet
excited
state
ground
(S2→S0)
drug's
within
polymeric
nanostructure.
Dynamic
light
scattering
revealed
that
nanoparticles,
initially
177.8
nm,
grew
226.6
nm
after
encapsulating
retaining
zeta
potential
stability.
With
a
68%
studies
showed
46
54
%
released
across
different
levels
510
minutes.
In
acidic
conditions,
there
is
greater
than
neutral
levels,
pH-responsive
profile
beneficial
treatment,
mechanism
OSANPs
following
Fickian
diffusion
as
identified
Korsmeyer-Peppas
mathematical
model
formulation
showing
improved
efficacy.
Pharmaceutical Development and Technology,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Янв. 7, 2025
In
this
paper,
the
pH-sensitive
targeting
functional
material
NGR-poly(2-ethyl-2-oxazoline)-cholesteryl
methyl
carbonate
(NGR-PEtOz-CHMC,
NPC)
modified
quercetin
(QUE)
liposomes
(NPC-QUE-L)
was
constructed.
The
structure
of
NPC
confirmed
by
infrared
spectroscopy
(IR)
and
nuclear
magnetic
resonance
hydrogen
spectrum
(1H-NMR).
Pharmacokinetic
results
showed
that
accumulation
QUE
in
plasma
NPC-QUE-L
group
1.28
times
2.43
Solution
QUE-L
groups,
respectively.
release
amount
an
acidic
environment
significantly
higher
than
physiological
pH
value.
order
tumor
cell
inhibition
rate
different
environments
>
PC-QUE-L
QUE-L.
addition,
cellular
uptake
NPC-modified
PC-modified
unmodified
liposomes,
indicating
had
good
pH-sensitivity
targeting.
triple-negative
breast
cancer
(TNBC)
model,
relative
proliferation
is
about
73%,
which
better
solution
group.
Western
blot
show
can
effectively
reduce
expression
α-smooth
actin
transforming
growth
factor-β1
tissues,
improve
degree
fibrosis.
study,
could
endow
with
stability,
pH-sensitivity,
targeting,
provides
a
reference
for
improving
solubility
poorly
soluble
natural
drug
components.
