Magnoflorine alleviates colitis-induced anxiety-like behaviors through regulating gut microbiota and microglia mediated neuroinflammation
Abstract
Background
Inflammatory
bowel
disease
(IBD)
and
anxiety
are
often
comorbid,
interconnected
through
the
microbiota-gut-brain
axis.
The
therapeutic
medications
for
constrained
by
adverse
effects
that
limit
their
long-term
use.
pursuit
of
natural,
safe
drug
is
important,
with
precise
mechanisms
elucidating
interplay
between
drugs
gut-brain
axis
in
modulating
mood
remaining
elusive.
Results
We
revealed
a
significant
association
active
ulcerative
colitis(UC)
patients
anxiety.
Mendelian
randomisation
analysis
suggested
UC
has
causal
relationship
on
anxiety,
but
not
depression.
Next
we
identified
Ziziphus
jujuba ,
natural
plant,
as
dual
agent
both
Batman
database.
Magnoflorine,
predominant
compound
found
exhibits
promising
properties
treatment
disorders.
Our
experiments
magnoflorine
only
alleviated
colitis,
also
reduced
colitis-induced
behaviors
gut
microbiota.
Mechanistically,
could
increase
abundance
Odoribacteraceae
Ruminococcus ,
regulate
bile
acid
metabolism,
especially
hyodeoxycholic
(HDCA)
colitis
mice.
HDCA
supplement
alleviate
Meanwhile
inhibit
binding
site
lipopolysaccharide
to
TLR4/MD2
complex,
thereby
inhibiting
microglia
activation
alleviating
neuroinflammation.
Conclusion
study
unveils
alleviates
anxiety-like
regulating
microbiota
mediated
neuroinflammation,
which
potential
IBD
comorbid
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Окт. 15, 2024
Язык: Английский