Magnoflorine alleviates colitis-induced anxiety-like behaviors through regulating gut microbiota and microglia mediated neuroinflammation DOI Creative Commons
Lei Wang, Mengfan Li, Yue Dong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Background Inflammatory bowel disease (IBD) and anxiety are often comorbid, interconnected through the microbiota-gut-brain axis. The therapeutic medications for constrained by adverse effects that limit their long-term use. pursuit of natural, safe drug is important, with precise mechanisms elucidating interplay between drugs gut-brain axis in modulating mood remaining elusive. Results We revealed a significant association active ulcerative colitis(UC) patients anxiety. Mendelian randomisation analysis suggested UC has causal relationship on anxiety, but not depression. Next we identified Ziziphus jujuba, natural plant, as dual agent both Batman database. Magnoflorine, predominant compound found exhibits promising properties treatment disorders. Our experiments magnoflorine only alleviated colitis, also reduced colitis-induced behaviors gut microbiota. Mechanistically, could increase abundance Odoribacteraceae Ruminococcus, regulate bile acid metabolism, especially hyodeoxycholic (HDCA) colitis mice. HDCA supplement alleviate Meanwhile inhibit binding site lipopolysaccharide to TLR4/MD2 complex, thereby inhibiting microglia activation alleviating neuroinflammation. Conclusion study unveils alleviates anxiety-like regulating microbiota mediated neuroinflammation, which potential IBD comorbid

Language: Английский

Physicochemical and stability analysis of mung bean protein hydrolysates with lipid peroxidation inhibition DOI
Yanqing Zhang, Wei Li,

Peilin Hou

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 463, P. 141135 - 141135

Published: Sept. 3, 2024

Language: Английский

Citations

7
Protective effects and regulatory mechanisms of Platycodin D against LPS-Induced inflammatory injury in BEAS-2B cells DOI
Wei Li,

Yanqing Zhang,

Yuxin Cao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112782 - 112782

Published: July 28, 2024

Language: Английский

Citations

6
Ultrasound-assisted extraction and antioxidant activity of triterpenoid saponins from Platycodon grandiflorum roots: Optimization, purification, and molecular insights DOI Creative Commons
Wei Li,

Yanqing Zhang,

Yinghao Wei

et al.

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 223, P. 119877 - 119877

Published: Oct. 23, 2024

Language: Английский

Citations

6
Exploring the Protective Effects of Spinosin Against Advanced Glycation End Product-Induced Cellular Damage Through Modulation RAGE/MAPK/ NF-κB pathway DOI
Wei Li, Yanqing Zhang, Na Tian

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105951 - 105951

Published: Jan. 1, 2025

Language: Английский

Citations

0
Comprehensive review of the expanding roles of the carnitine pool in metabolic physiology: beyond fatty acid oxidation DOI Creative Commons

Feng Xiang,

Zhimin Zhang, Jingchen Xie

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 14, 2025

Traditionally, the carnitine pool is closely related to fatty acid metabolism. However, with increasing research, pleiotropic effects of have gradually emerged. The purpose this review comprehensively investigate emerging understanding role pool, carnitine/acylcarnitines are not only auxiliaries or metabolites oxidation, but also play more complex and diverse roles, including energy metabolism, mitochondrial homeostasis, epigenetic regulation, regulation inflammation immune system, tumor biology, signal transduction, neuroprotection. This provides an overview network synthesis, transport, shuttle, potential be used as communication molecules, biomarkers therapeutic targets for multiple diseases, profound on intercellular communication, metabolic interactions between organs overall health. summarize multidimensional biological beyond its traditional in oxidation systemic mediated by carnitine/acylcarnitine provide new perspectives pharmacological research treatment innovation strategies prevention a variety diseases.

Language: Английский

Citations

0
Melanoidins from stir-frying Atractylodes Macrocephala: Structural characterization, molecular weight distribution, and polyphenol delivery mechanism DOI
Wei Li, Yajie Zhang, Xiaoxiao Wang

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144238 - 144238

Published: April 1, 2025

Language: Английский

Citations

0
Unraveling the mysteries of melanoidins: insights into formation, structure, and health potential in fermented blacken foods DOI

Yanqing Zhang,

Wei Li,

Junbo Xie

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: Nov. 29, 2024

Fermentation is widely known for its ability to enhance the food nutritional ingredients, and products are with improved texture, flavor, nutritional. Fermented blacken foods (FBF) a unique group of characterized by their darker hue while retaining benefits. Despite popularity, research on melanoidins, compounds responsible characteristic color health-promoting properties FBF, remains limited. This review summarizes formation, extraction, purification, structural features, health benefits melanoidins in FBF. The relationship between preparation methods, physicochemical bioactivities was elucidated. formation influenced Maillard reaction (MR) microbial metabolic activity analyzed, highlighting dynamic nature melanoidin synthesis fermentation systems. Furthermore, addresses characteristics FBF production processes role microorganisms enzymes formation. Melanoidins exhibit diverse chemical compositions molecular structures, precursor molecules, pathways, environmental factors. These contribute sensory attributes, stability, bioactivity including antioxidant, antimicrobial, prebiotic properties. underscores importance influences quality, nutrition, health.

Language: Английский

Citations

2
Carnitine traffic and human fertility DOI Creative Commons
Tiziano Mazza, Mariafrancesca Scalise, Lara Console

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 116565 - 116565

Published: Oct. 1, 2024

Language: Английский

Citations

1
Magnoflorine alleviates colitis-induced anxiety-like behaviors through regulating gut microbiota and microglia mediated neuroinflammation DOI Creative Commons
Lei Wang, Mengfan Li, Yue Dong

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Background Inflammatory bowel disease (IBD) and anxiety are often comorbid, interconnected through the microbiota-gut-brain axis. The therapeutic medications for constrained by adverse effects that limit their long-term use. pursuit of natural, safe drug is important, with precise mechanisms elucidating interplay between drugs gut-brain axis in modulating mood remaining elusive. Results We revealed a significant association active ulcerative colitis(UC) patients anxiety. Mendelian randomisation analysis suggested UC has causal relationship on anxiety, but not depression. Next we identified Ziziphus jujuba, natural plant, as dual agent both Batman database. Magnoflorine, predominant compound found exhibits promising properties treatment disorders. Our experiments magnoflorine only alleviated colitis, also reduced colitis-induced behaviors gut microbiota. Mechanistically, could increase abundance Odoribacteraceae Ruminococcus, regulate bile acid metabolism, especially hyodeoxycholic (HDCA) colitis mice. HDCA supplement alleviate Meanwhile inhibit binding site lipopolysaccharide to TLR4/MD2 complex, thereby inhibiting microglia activation alleviating neuroinflammation. Conclusion study unveils alleviates anxiety-like regulating microbiota mediated neuroinflammation, which potential IBD comorbid

Language: Английский

Citations

0