Inorganic Chemistry Communications, Год журнала: 2024, Номер unknown, С. 113765 - 113765
Опубликована: Дек. 1, 2024
Язык: Английский
Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12
Опубликована: Июль 11, 2024
Cancer, being one of the deadliest diseases, poses significant challenges despite existence traditional treatment approaches. This has led to a growing demand for innovative pharmaceutical agents that specifically target cancer cells effective treatment. In recent years, use metal nanoparticles (NPs) as promising alternative conventional therapies gained prominence in research. Metal NPs exhibit unique properties hold tremendous potential various applications Studies have demonstrated certain metals possess inherent or acquired anticancer capabilities through their surfaces. These make an attractive focus therapeutic development. this review, we will investigate applicability several distinct classes tumor targeting may include gold, silver, iron oxide, and other with can be exploited purposes. Additionally, provide comprehensive summary risk factors associated application NPs. Understanding addressing these crucial successful clinical translation mitigate any failures NP-based therapies. By exploring identifying factors, review aims contribute advancement strategies. The anticipated outcome is valuable insights pave way targeted utilizing patients.
Язык: Английский
Процитировано
26
International Journal of Pharmaceutics, Год журнала: 2025, Номер 670, С. 125186 - 125186
Опубликована: Янв. 8, 2025
The blood-brain barrier (BBB) plays a vital role in protecting the central nervous system (CNS) by preventing entry of harmful pathogens from bloodstream. However, this also presents significant obstacle when it comes to delivering drugs for treatment neurodegenerative diseases and brain cancer. Recent breakthroughs nanotechnology have paved way creation wide range nanoparticles (NPs) that can serve as carriers diagnosis therapy. Regarding their promising properties, organic NPs potential be used effective drug delivery across BBB based on recent advancements. These remarkable ability penetrate using various mechanisms. This review offers comprehensive examination intricate structure distinct properties BBB, emphasizing its crucial function preserving balance regulating transport ions molecules. disruption conditions such stroke, Alzheimer's disease, Parkinson's disease highlights importance developing creative approaches drugs. Through encapsulation therapeutic molecules precise targeting processes vasculature, NP formulations present hopeful strategy improve BBB. We explore changes pathological investigate factors affect successful into brain. In addition, we most systems associated with shown positive results treating ischemic disorders. opens up new possibilities nanotechnology-based therapies cerebral diseases.
Язык: Английский
Процитировано
10
European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 287, С. 117357 - 117357
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
6
Deleted Journal, Год журнала: 2024, Номер 6(8)
Опубликована: Июль 29, 2024
Abstract Arteriosclerosis (AS) presents a significant global health challenge, demanding innovative therapeutic strategies. This review explores the potential of nanoparticles (NPs) and mesenchymal stem cells (MSCs) as promising modalities for treating AS. NPs enable targeted drug delivery, while MSCs possess immunomodulatory regenerative capabilities. We discuss recent advances in NP-based delivery systems tailored AS treatment highlight MSCs’ roles modulating inflammation promoting vascular repair. Additionally, we examine synergistic effects combining enhanced outcomes. Furthermore, this paper provides insights into targeting endothelial cells, T-cells, macrophages, lipid levels, plaques using MSCs. It also reviews various types metal-based non-metallic utilized therapy. comprehensive overview underscores synergies between cardiovascular disease therapy, emphasizing need further research to fully realize their implications. Graphical
Язык: Английский
Процитировано
13
Biomedical Physics & Engineering Express, Год журнала: 2024, Номер 10(5), С. 052002 - 052002
Опубликована: Авг. 14, 2024
Abstract Purpose . This review aims to highlight current improvements in microfluidic devices designed for digestive cancer simulation. The emphasizes the use of multicellular 3D tissue engineering models understand complicated biology tumor microenvironment (TME) and progression. purpose is develop oncology research improve patients’ lives. Methods analyzes recent on mimicking cancer. It uses tissue-engineered devices, notably organs a chip (OOC), simulate human organ function lab. Cell cultivation modern three-dimensional hydrogel platforms allows precise geometry, biological components, physiological qualities. novel methodologies, key findings, technical progress explain this field’s advances. Results study discusses advances Micro systems with are emphasized. These capture complex biochemical gradients, niche variables, dynamic cell–cell interactions (TME). reveal stomach progression by duplicating TME. Recent discoveries technology have improved our understanding gut biology, as shown review. Conclusion Microfluidic play crucial role modeling furthering research. could transform drug development treatment revealing provides complete summary suggests future field professionals. review’s major goal further medical
Язык: Английский
Процитировано
13
Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown
Опубликована: Авг. 26, 2024
Язык: Английский
Процитировано
10
International Communications in Heat and Mass Transfer, Год журнала: 2025, Номер 164, С. 108895 - 108895
Опубликована: Март 29, 2025
Язык: Английский
Процитировано
1
Biomedical Materials, Год журнала: 2024, Номер 19(5), С. 052004 - 052004
Опубликована: Июль 29, 2024
Quantum dots (QDs) are with exceptional physicochemical and biological properties, making them highly versatile for a wide range of applications in cancer therapy. One the key features QDs is their unique electronic structure, which gives functional attributes. Notably, photoluminescence can be strong adjustable, allowing to effectively used fluorescence based diagnosis such as biosensing bioimaging. In addition, demonstrate an impressive capacity loading cargo, ideal drug delivery applications. Moreover, ability absorb incident radiation positions promising candidates cancer-killing techniques like photodynamic The objective this comprehensive review present current overview recent advancements utilizing multifunctional innovative biomaterials. This focuses on elucidating biological, electronic, properties QDs, along discussing technical QD synthesis. Furthermore, it thoroughly explores progress made biosensing, bioimaging, therapy including necrosis, highlighting significant potential field treatment. addresses limitations associated provides valuable insights into future directions, thereby facilitating further field. By presenting well-structured overview, serves authoritative informative resource that guide research endeavors foster continued
Язык: Английский
Процитировано
6
npj Systems Biology and Applications, Год журнала: 2024, Номер 10(1)
Опубликована: Ноя. 20, 2024
Intratumoral delivery and localized chemotherapy have demonstrated promise in tumor treatment; however, the rapid drainage of therapeutic agents from well-vascularized tumors limits their ability to achieve maximum efficacy. Therefore, innovative approaches are needed enhance treatment efficacy such tumors. This study utilizes a mathematical modeling platform assess combination therapy using anti-angiogenic drugs drug-loaded nanoparticles. Anti-angiogenic included reduce blood microvascular density facilitate drug retention extracellular space. In addition, incorporating negatively charged nanoparticles aims diffusion distribution within The findings indicate that, case direct injection free drugs, compounds with lower rates higher coefficients is beneficial for achieving broader diffusion. Otherwise, tend accumulate primarily around site. For instance, doxorubicin, known its drainage, requires prior an high rate distribution, enhancing penetration depth by 200%. Moreover, results demonstrate that effectively disperse throughout tissue due coefficient. faster release further efficacy, necessary concentration complete eradication compared slower rates. demonstrates potential utilizing loaded exhibiting through intratumoral
Язык: Английский
Процитировано
5
ACS Applied Bio Materials, Год журнала: 2024, Номер 7(11), С. 7556 - 7573
Опубликована: Ноя. 6, 2024
Triple-negative breast cancer (TNBC) is recognized as a major aggressive subtype of due to its expeditious worsening growth, extensive metastatic capability, and recalcitrance standard current treatments. Hesperetin (HSP), natural bioflavonoid from citrus fruits, demonstrates pronounced anticancer efficacy, but hydrophobicity limits clinical development. The present study reports the fabrication biocompatible pH-responsive transferrin (TF) receptor-targeted HSP-loaded poly(lactic-co-glycolic acid) (PLGA) nanobioconjugate (PLGA-HSP-TF NPs) exploration in vitro vivo antineoplastic potential. PLGA nanoparticles (NPs), PLGA-HSP NPs, PLGA-HSP-TF NPs were synthesized characterized by DLS, FTIR, FE-SEM, 1H NMR spectroscopy. stability release profile inspected, efficacy was scrutinized terms cytotoxicity, oxidative stress apoptosis biomarkers, cell cycle arrest. In tumor regression host survival studies executed Ehrlich ascites carcinoma (EAC) cell-bearing Swiss albino mice. drug uptake highly stable accomplished effectively MDA-MB-231 cells showed pH-dependent intracellular HSP, which generated excessive reactive oxygen species (ROS) that led assault TNBC cells. This elevated ROS dropped mitochondrial membrane potential triggered apoptosis-mediated death arresting at G0/G1 phase. Furthermore, unveiled significant compared free HSP with minimum toxicity dose 20 mg/kg body weight. divulges may be an astounding nanocandidate for triple-negative therapy.
Язык: Английский
Процитировано
4