Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 595 - 613
Опубликована: Окт. 4, 2024
Язык: Английский
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 595 - 613
Опубликована: Окт. 4, 2024
Язык: Английский
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 174, С. 116453 - 116453
Опубликована: Март 20, 2024
Sepsis-associated encephalopathy (SAE), a common neurological complication of sepsis, is heterogenous complex clinical syndrome caused by the dysfunctional response host to infection. This leads excess mortality and morbidity worldwide. Despite relevance with high incidence, there lack understanding for its both acute/chronic pathogenesis therapeutic management. A better molecular mechanisms behind SAE may provide tools enhance efficacy. Mounting evidence indicates that some types non-apoptotic regulated cell death (RCD), such as ferroptosis, pyroptosis, autophagy, contribute SAE. Targeting these RCD meaningful targets future treatments against review summarizes core mechanism which We focus on emerging compounds can inhibit delineate their beneficial pharmacological effects Within this we suggest inhibition serve potential strategy
Язык: Английский
Процитировано
15International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(10), С. 5222 - 5222
Опубликована: Май 10, 2024
Flavonoids, a variety of plant secondary metabolites, are known for their diverse biological activities. Isoflavones subgroup flavonoids that have gained attention potential health benefits. Puerarin is one the bioactive isoflavones found in Kudzu root and Pueraria genus, which widely used alternative Chinese medicine, has been to be effective treating chronic conditions like cardiovascular diseases, liver gastric respiratory diabetes, Alzheimer’s disease, cancer. extensively researched both scientific clinical studies over past few years. The purpose this review provide an up-to-date exploration puerarin biosynthesis, most common extraction methods, analytical techniques, effects, new perspective medical pharmaceutical research development.
Язык: Английский
Процитировано
11Journal of Ethnopharmacology, Год журнала: 2023, Номер 319, С. 117262 - 117262
Опубликована: Окт. 1, 2023
Язык: Английский
Процитировано
18Molecular Neurobiology, Год журнала: 2024, Номер unknown
Опубликована: Март 27, 2024
Язык: Английский
Процитировано
7Food & medicine homology., Год журнала: 2024, Номер 2(2), С. 9420033 - 9420033
Опубликована: Сен. 4, 2024
Язык: Английский
Процитировано
7Foods, Год журнала: 2024, Номер 13(4), С. 591 - 591
Опубликована: Фев. 15, 2024
Background: Hyperuricaemia (HUA) is a disorder of purine metabolism in the body. We previously synthesized hesperitin (Hsp)-Cu(II) complex and found that possessed strong uric acid (UA)-reducing activity vitro. In this study we further explored complex’s UA-lowering nephroprotective effects vivo. Methods: A mouse with HUA was used to investigate hypouricemic via biochemical analysis, RT-PCR, Western blot. Results: Hsp-Cu(II) markedly decreased serum UA level restored kidney tissue damage normal mice. Meanwhile, inhibited liver adenosine deaminase (ADA) xanthine oxidase (XO) activities reduce synthesis modulated protein expression urate transporters promote excretion. treatment significantly suppressed oxidative stress inflammatory kidney, reduced contents cytokines activation nucleotide-binding oligomerization domain (NOD)-like receptor thermal associated 3 (NLRP3) pathway. Conclusions: protected kidneys from renal by modulating NLRP3 may be promising dietary supplement or nutraceutical for therapy hyperuricemia.
Язык: Английский
Процитировано
4CNS Neuroscience & Therapeutics, Год журнала: 2024, Номер 30(12)
Опубликована: Дек. 1, 2024
ABSTRACT Background The treatment of spinal cord injury (SCI) is usually ineffective, because neuroinflammatory secondary an important cause the continuous development injury, and microglial pyroptosis step neuroinflammation. Recently, Bmal1, a core component circadian clock genes (CCGs), has been shown to play regulatory role in various tissues cells. However, it still unclear whether Bmal1 regulates after SCI. Methods In this study, we established vivo mouse model SCI using knockout (KO) mice wild‐type (WT) mice, lipopolysaccharide (LPS)‐induced BV2 cells as vitro model. A series molecular histological methods were used detect level explore mechanism respectively. Results Both results showed that inhibited NLRP3 inflammasome activation Further analysis pyroptosis‐related proteins (NLRP3, Caspase‐1, ASC, GSDMD‐N) reduced release IL‐18 IL‐1β by inhibiting NF‐κB /MMP9 pathway. It was identified transcription factor promotes expression MMP9, which turn Conclusions Our study initially pathway reduce thereby providing new promising therapeutic target for
Язык: Английский
Процитировано
3CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(1)
Опубликована: Янв. 1, 2025
Neuroinflammation is one of the essential pathogeneses cognitive damage suffering from sepsis-associated encephalopathy (SAE). Lots evidences showed microglia presented mitochondrial fragmentation during SAE. This study investigated protective effects and novel mechanisms inhibiting via division inhibitor 1 (Mdivi-1) on in The SAE model was performed by cecal ligation puncture (CLP), Mdivi-1 administrated intraperitoneal injection. Morris water maze to assess function. Mitochondrial morphology observed electron microscope or MitoTracker staining. qRT-PCR, immunofluorescence staining, western blots were used detect inflammatory factors protein content, respectively. Flow cytometry polarization hippocampal microglia. Bioinformatics analysis verify hypotheses. administration alleviated sepsis-induced fragmentation, activation, polarization, damage. neuroinflammation oxidative stress suppressed NF-κB Keap1/Nrf2/HO-1 pathways following administration; meanwhile, pyroptosis reduced, which associated with enhanced autophagosome formation p62 elevation administration. Inhibition beneficial disturbance, are related alleviating neuroinflammation, stress, pyroptosis.
Язык: Английский
Процитировано
0Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 1787 - 1813
Опубликована: Фев. 1, 2025
Abstract: Reversion inducing cysteine rich protein with kazal motifs (RECK), a Kazal motif-containing protein, regulates pro-inflammatory cytokines production, migration of inflammatory cells, vascular endothelial growth factor (VEGF) and Wnt pathways plays critical roles in septic storms dysfunction. Recently, RECK has been defined as the negative regulator adisintegrin metalloproteinases (ADAMs) matrix (MMPs), which are both membrane "molecular scissors" aggravate poor prognosis sepsis. To better understand related mechanisms, we make here systematic in-depth review RECK. We first summarize findings on structural characteristics regulation at transcription, post-transcription, or level Then, discuss inflammation, infection, injury by focusing function ADAMs MMPs, well VEGF, WNT, angiopoietin, notch signaling. In conclusion, participation guardian development sepsis provides insight into strategies precisely intervening dysregulationfor treatment Keywords: RECK, sepsis, regulation, inflammation
Язык: Английский
Процитировано
0Free Radical Biology and Medicine, Год журнала: 2025, Номер 232, С. 340 - 352
Опубликована: Март 13, 2025
Язык: Английский
Процитировано
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