The pathological mechanisms and potential therapeutic drugs for myocardial ischemia reperfusion injury

Phytomedicine, Год журнала: 2024, Номер 129, С. 155649 - 155649

Опубликована: Апрель 17, 2024

Язык: Английский

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Puerarin pretreatment provides protection against myocardial ischemia/reperfusion injury via inhibiting excessive autophagy and apoptosis by modulation of HES1

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 4, 2025

The study aimed to elucidate the underlying pharmacological mechanism of traditional Chinese medicine Pue in ameliorating myocardial ischemia-reperfusion injury (MIRI), a critical clinical challenge exacerbated by reperfusion therapy. In vivo MIRI and vitro anoxia/reoxygenation (A/R) models were constructed. results demonstrated that pretreatment effectively alleviated MIRI, as manifested diminishing levels serum CK-MB LDH, mitigating extent infarction enhancing cardiac functionality. Additionally, significantly histopathological damage MIRI-treated myocardium, evidenced HE staining TUNEL assay. vitro, A/R-induced decreasing LDH levels, increasing cellular activity, inhibiting autophagic lysosomal overactivation, oxidative stress (ROS, LIP ROS, MDA), antioxidant defense (SOD, GSH-Px), P62 protein expression while LC3II/I ratio. Furthermore, inhibited apoptosis maintained mitochondrial homeostasis up-regulating Hairy Enhancer Split-1 (HES1) protein, which was crucial for its cardioprotective effects. Nevertheless, efficacy negated via knockdown HES1 pAD/HES1-shRNA transfection. conclusion, ameliorated HES1-mediated MIRI-induced autophagy, apoptosis, dysfunction.

Язык: Английский

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Different types of cell death and their interactions in myocardial ischemia–reperfusion injury

Cell Death Discovery, Год журнала: 2025, Номер 11(1)

Опубликована: Март 5, 2025

Myocardial ischemia-reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow restored to the heart tissue following ischemia-induced damage. Cardiomyocyte cell death, particularly through apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, pivotal myocardial I/R injury. Preventing death during of vital for improving ischemic cardiomyopathy. These multiple forms can occur simultaneously, interact each other, contribute complexity In this review, we aim provide comprehensive summary key molecular mechanisms regulatory patterns involved these five types We will also discuss crosstalk intricate interactions among mechanisms, highlighting interplay between different death. Furthermore, explore specific molecules or targets that participate pathways elucidate their action. It important note manipulating distinct processes may have significant impact on reducing By enhancing researchers' understanding injury, review aims pave way development novel interventions cardio-protection affected by

Язык: Английский

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Multidimensional biological activities of resveratrol and its prospects and challenges in the health field

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Июнь 12, 2024

Resveratrol (RES) is a naturally occurring polyphenolic compound. Recent studies have identified multiple potential health benefits of RES, including antioxidant, anti-inflammatory, anti-obesity, anticancer, anti-diabetic, cardiovascular, and neuroprotective properties. The objective this review to summarize analyze the on biological activities RES in disease prevention treatment, as well its metabolism bioavailability. It also discusses challenges clinical application future research directions. exhibits significant treatment many diseases. direction should focus improving bioavailability, conducting more trials determine effectiveness humans, investigating mechanism action. Once these been overcome, expected become an effective intervention.

Язык: Английский

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Crosstalk among Reactive Oxygen Species, Autophagy and Metabolism in Myocardial Ischemia and Reperfusion Stages

Aging and Disease, Год журнала: 2023, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2023

Myocardial ischemia is the most common cardiovascular disease. Reperfusion, an important myocardial tool, causes unexpected and irreversible damage to cardiomyocytes, resulting in ischemia/reperfusion (MI/R) injury. Upon stress, especially oxidative stress induced by reactive oxygen species (ROS), autophagy, which degrades intracellular energy storage produce metabolites that are recycled into metabolic pathways buffer initiated during MI/R Excellent cardioprotective effects of autophagy regulators against MI have been reported. Reversing disordered cardiac metabolism ROS also exhibits action patients with ischemia. Herein, we review current knowledge on crosstalk between ROS, MI/R. Finally, discuss possible can be exploited harness therapeutic potential diagnosis treatment

Язык: Английский

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In vivo and in vitro study on the regulatory mechanism of XiaoChaiHu decoction on PANoptosis in sepsis-induced cardiomyopathy

Journal of Ethnopharmacology, Год журнала: 2024, Номер 336, С. 118740 - 118740

Опубликована: Авг. 27, 2024

Язык: Английский

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The PINK1/Parkin signaling pathway-mediated mitophagy: a forgotten protagonist in myocardial ischemia/reperfusion injury

Pharmacological Research, Год журнала: 2024, Номер 209, С. 107466 - 107466

Опубликована: Окт. 15, 2024

Myocardial ischemia causes extensive damage, further exacerbated by reperfusion, a phenomenon called myocardial ischemia/reperfusion injury (MIRI). Nowadays, the pathological mechanisms of MIRI have received attention. Oxidative stress, multiple programmed cell deaths, inflammation and others are all essential contributing to MIRI. Mitochondria energy supply centers cells. Numerous studies found that abnormal mitochondrial function is an "culprit" MIRI, mitophagy mediated phosphatase tensin homolog (PTEN)-induced kinase 1 (PINK1)/Parkin signaling pathway integral part maintaining function. Therefore, exploring association between PINK1/Parkin pathway-mediated crucial. This review will mainly summarize crucial role in MIR-induced several various potential interventions affect mitophagy, thus ameliorating

Язык: Английский

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Hederagenin protects against myocardial ischemia–reperfusion injury via attenuating ALOX5-mediated ferroptosis

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2023, Номер 397(5), С. 3411 - 3424

Опубликована: Ноя. 13, 2023

Язык: Английский

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Sephin1 enhances integrated stress response and autophagy to alleviate myocardial ischemia-reperfusion injury in mice

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116869 - 116869

Опубликована: Июнь 7, 2024

Integrated stress response (ISR) is activated to promote cell survival by maintaining the phosphorylation of eukaryotic translation initiation factor 2 (eIF2α). We investigated whether Sephin1 enhances ISR and attenuates myocardial ischemia-reperfusion (MIR) injury.

Язык: Английский

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Impact of plant-derived antioxidants on heart aging: a mechanistic outlook

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

Heart aging involves a complex interplay of genetic and environmental influences, leading to gradual deterioration cardiovascular integrity function. Age-related physiological changes, including ventricular hypertrophy, diastolic dysfunction, myocardial fibrosis, increased arterial stiffness, endothelial are influenced by key mechanisms like autophagy, inflammation, oxidative stress. This review aims explore the therapeutic potential plant-derived bioactive antioxidants in mitigating heart aging. These compounds, often rich polyphenols, flavonoids, other phytochemicals, exhibit notable antioxidant, anti-inflammatory, cardioprotective properties. substances have intricate properties, ability scavenge ROS, enhance endogenous antioxidant defenses, regulate signaling pathways, impede fibrosis inflammation-promoting processes. By focusing on molecular linked cardiac aging, produced from plants provide significant promise reduce age-related decline improve general health. Through comprehensive analysis preclinical clinical studies, this work highlights associated with promising effects antioxidants. The findings may helpful for researchers identifying specific molecules preventive heart.

Язык: Английский

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