Cardiovascular Therapeutics,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Ischemic
heart
disease
(IHD)
remains
one
of
the
most
prominent
causes
mortality
and
morbidity
globally,
risk
ischemia–reperfusion
injury
is
becoming
more
severe
constant.
This
underscores
need
to
develop
new
methods
protect
from
damage.
DJ‐1
a
multifunctional
intracellular
protein
encoded
by
PARK7
gene
that
plays
roles
in
processes
including
control
autophagy,
preservation
mitochondrial
integrity,
prevention
apoptosis,
elimination
oxidative
stress.
has
recently
been
focus
growing
interest
as
target
molecule
relevant
treating
myocardial
due
its
protective
properties
role
cellular
response
mechanisms.
Consistently,
DJ‐1‐related
interventions,
such
exogenous
administration
or
use
pharmacological
agents,
have
demonstrated
help
myocardium
associated
adverse
outcomes.
review
provides
an
overview
therapeutic
relevance
setting
ischemia
reperfusion.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 5, 2025
Myocardial
cold
ischemia/reperfusion
(I/R)
injury
is
an
inevitable
consequence
of
heart
transplantation,
significantly
affecting
survival
rates
and
therapeutic
outcomes.
Growth
Differentiation
Factor
15
(GDF15)
has
been
shown
to
regulate
GPX4-mediated
ferroptosis,
playing
a
critical
role
in
mitigating
I/R
injury.
Meanwhile,
verbascoside
(VB),
active
compound
extracted
from
the
herbaceous
plant,
demonstrated
myocardial
protective
effects.
In
this
study,
transplantation
was
performed
using
modified
non-suture
cuff
technique,
with
VB
administered
at
dose
20
mg/kg/day
via
intraperitoneal
injection
for
3
days
vivo.
vitro,
cardiomyocytes
were
pretreated
50
µg/ml
24
h.
treatment
reduced
histopathological
injury,
decreased
markers,
inhibited
ferroptosis
oxidative
stress
during
vitro
experiments
further
that
GDF15
alleviates
induced
by
hypoxic
reoxygenation
upregulating
GPX4.
Therefore,
it
concluded
preconditioning
can
effectively
reduce
after
heterotopic
possibly
through
up-regulation
GDF15/GPX4/SLC7A11
pathway.
Aging and Disease,
Год журнала:
2023,
Номер
unknown, С. 0 - 0
Опубликована: Янв. 1, 2023
Myocardial
ischemia
is
the
most
common
cardiovascular
disease.
Reperfusion,
an
important
myocardial
tool,
causes
unexpected
and
irreversible
damage
to
cardiomyocytes,
resulting
in
ischemia/reperfusion
(MI/R)
injury.
Upon
stress,
especially
oxidative
stress
induced
by
reactive
oxygen
species
(ROS),
autophagy,
which
degrades
intracellular
energy
storage
produce
metabolites
that
are
recycled
into
metabolic
pathways
buffer
initiated
during
MI/R
Excellent
cardioprotective
effects
of
autophagy
regulators
against
MI
have
been
reported.
Reversing
disordered
cardiac
metabolism
ROS
also
exhibits
action
patients
with
ischemia.
Herein,
we
review
current
knowledge
on
crosstalk
between
ROS,
MI/R.
Finally,
discuss
possible
can
be
exploited
harness
therapeutic
potential
diagnosis
treatment
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
176, С. 116869 - 116869
Опубликована: Июнь 7, 2024
Integrated
stress
response
(ISR)
is
activated
to
promote
cell
survival
by
maintaining
the
phosphorylation
of
eukaryotic
translation
initiation
factor
2
(eIF2α).
We
investigated
whether
Sephin1
enhances
ISR
and
attenuates
myocardial
ischemia-reperfusion
(MIR)
injury.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11003 - 11003
Опубликована: Окт. 13, 2024
Zearalenone
(ZEA)
is
a
mycotoxin
produced
by
Fusarium
spp.
fungi
and
widely
found
in
moldy
corn,
wheat,
barley,
other
grains.
ZEA
distributed
to
the
whole
body
via
blood
circulation
after
metabolic
transformation
animals.
Through
oxidative
stress,
immunosuppression,
apoptosis,
autophagy,
mitochondrial
dysfunction,
leads
hepatitis,
neurodegenerative
diseases,
cancer,
abortion,
stillbirth
female
animals,
decreased
sperm
motility
male
In
recent
years,
due
influence
of
climate,
storage
facilities,
factors,
problem
pollution
global
food
crops
has
become
particularly
prominent,
resulting
serious
problems
for
animal
husbandry
feed
industries,
threatening
human
health.
Resveratrol
(RSV)
natural
product
with
therapeutic
activities
such
as
anti-inflammatory,
antioxidant,
anticancer
properties.
RSV
can
alleviate
ZEA-induced
toxic
effects
targeting
signaling
pathways
NF-κB,
Nrf2/Keap1,
PI3K/AKT/mTOR
attenuating
damage,
inflammatory
response,
regulating
cellular
autophagy.
Therefore,
this
paper
provides
review
protective
effect
against
toxicity
its
molecular
mechanism,
discusses
safety
potential
clinical
applications
search
detoxification
agents.
Vascular Pharmacology,
Год журнала:
2023,
Номер
152, С. 107208 - 107208
Опубликована: Авг. 11, 2023
Here
we
aimed
to
establish
an
in
vitro
engineered
heart
tissue
(EHT)
co-morbidity
mimicking
model
of
ischemia-reperfusion
injury
and
diabetes.
EHTs
were
generated
from
primary
neonatal
rat
cardiomyocytes.
Hyperglycemic
conditions
or
hyperosmolar
controls
applied
for
one
day
acute
hyperglycemia
seven
days
chronic
hyperglycemia.
120
min'
simulated
ischemia
(SI)
was
followed
by
reperfusion
(R)
1-day
follow-up
(FR).
Normoxic
(N)
not
subjected
SI/R.
Half
the
paced,
other
half
left
unpaced.
To
assess
cell
injury,
lactate-dehydrogenase
(LDH)
concentration
measured.
Beating
force
activity
(frequency)
monitored
as
cardiomyocyte
functional
parameters.
LDH-release
indicated
relevant
after
SI/N
each
experimental
condition,
with
much
higher
effects
chronically
hyperglycemic/hyperosmolar
groups.
SI
stopped
beating
which
returned
during
reperfusion,
weaker
recovery
than
conditions.
Acutely
treated
showed
small
∼80%
follow-up,
while
a
marked
LDH-release,
only
∼30%
complete
loss
24
h
reperfusion.
We
conclude
that
respond
differently
SI/R
hyperglycemia/hyperosmolarity,
our
EHT
is
novel
combination
diabetes
ischemia-reperfusion.
