Oncology Letters,
Journal Year:
2024,
Volume and Issue:
28(6)
Published: Sept. 30, 2024
Lin28A
is
an
oncoprotein
overexpressed
in
several
cancer
types
such
as
testicular,
ovarian,
colon,
breast
and
lung
cancers.
As
a
pluripotency
factor
that
promotes
tumorigenesis,
associated
with
more
undifferentiated
aggressive
tumors
phenotypes.
Moreover,
highly
stable
protein
difficult
to
downregulate.
The
compound
resveratrol
(RSV)
has
anticancer
effects.
present
study
aimed
elucidate
the
mechanisms
underlying
downregulation
of
expression
by
RSV
NCCIT
cell
line.
cells
were
treated
different
concentrations
investigate
its
effects
on
expression.
mRNA
levels
ubiquitin-specific
protease
28
(USP28)
assessed
using
reverse
transcription-quantitative
PCR.
Western
blot
analysis
was
employed
evaluate
Lin28A,
USP28
phosphorylated
Lin28A.
In
addition,
some
experiments,
MAPK/ERK
pathway
inhibitor,
other
experiments
involved
transfecting
small
interfering
RNAs
targeting
USP28.
results
demonstrated
significantly
reduced
destabilizing
protein;
this
effect
mediated
ability
suppress
USP28,
deubiquitinase
normally
protects
from
ubiquitination
degradation.
Additionally,
inhibited
phosphorylation
via
pathway;
event
previously
been
shown
enhance
stability
increasing
half-life.
This
resulted
degradation
through
proteasomal
cells.
provide
further
evidence
activity
RSV,
identified
promising
therapeutic
targets.
oncoprotein,
downregulating
challenging.
However,
can
overcome
hurdle
inhibiting
signaling
promote
Furthermore,
elucidating
these
provides
avenues
for
developing
targeted
therapies.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 5, 2025
Myocardial
cold
ischemia/reperfusion
(I/R)
injury
is
an
inevitable
consequence
of
heart
transplantation,
significantly
affecting
survival
rates
and
therapeutic
outcomes.
Growth
Differentiation
Factor
15
(GDF15)
has
been
shown
to
regulate
GPX4-mediated
ferroptosis,
playing
a
critical
role
in
mitigating
I/R
injury.
Meanwhile,
verbascoside
(VB),
active
compound
extracted
from
the
herbaceous
plant,
demonstrated
myocardial
protective
effects.
In
this
study,
transplantation
was
performed
using
modified
non-suture
cuff
technique,
with
VB
administered
at
dose
20
mg/kg/day
via
intraperitoneal
injection
for
3
days
vivo.
vitro,
cardiomyocytes
were
pretreated
50
µg/ml
24
h.
treatment
reduced
histopathological
injury,
decreased
markers,
inhibited
ferroptosis
oxidative
stress
during
vitro
experiments
further
that
GDF15
alleviates
induced
by
hypoxic
reoxygenation
upregulating
GPX4.
Therefore,
it
concluded
preconditioning
can
effectively
reduce
after
heterotopic
possibly
through
up-regulation
GDF15/GPX4/SLC7A11
pathway.
Aging and Disease,
Journal Year:
2023,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2023
Myocardial
ischemia
is
the
most
common
cardiovascular
disease.
Reperfusion,
an
important
myocardial
tool,
causes
unexpected
and
irreversible
damage
to
cardiomyocytes,
resulting
in
ischemia/reperfusion
(MI/R)
injury.
Upon
stress,
especially
oxidative
stress
induced
by
reactive
oxygen
species
(ROS),
autophagy,
which
degrades
intracellular
energy
storage
produce
metabolites
that
are
recycled
into
metabolic
pathways
buffer
initiated
during
MI/R
Excellent
cardioprotective
effects
of
autophagy
regulators
against
MI
have
been
reported.
Reversing
disordered
cardiac
metabolism
ROS
also
exhibits
action
patients
with
ischemia.
Herein,
we
review
current
knowledge
on
crosstalk
between
ROS,
MI/R.
Finally,
discuss
possible
can
be
exploited
harness
therapeutic
potential
diagnosis
treatment
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11003 - 11003
Published: Oct. 13, 2024
Zearalenone
(ZEA)
is
a
mycotoxin
produced
by
Fusarium
spp.
fungi
and
widely
found
in
moldy
corn,
wheat,
barley,
other
grains.
ZEA
distributed
to
the
whole
body
via
blood
circulation
after
metabolic
transformation
animals.
Through
oxidative
stress,
immunosuppression,
apoptosis,
autophagy,
mitochondrial
dysfunction,
leads
hepatitis,
neurodegenerative
diseases,
cancer,
abortion,
stillbirth
female
animals,
decreased
sperm
motility
male
In
recent
years,
due
influence
of
climate,
storage
facilities,
factors,
problem
pollution
global
food
crops
has
become
particularly
prominent,
resulting
serious
problems
for
animal
husbandry
feed
industries,
threatening
human
health.
Resveratrol
(RSV)
natural
product
with
therapeutic
activities
such
as
anti-inflammatory,
antioxidant,
anticancer
properties.
RSV
can
alleviate
ZEA-induced
toxic
effects
targeting
signaling
pathways
NF-κB,
Nrf2/Keap1,
PI3K/AKT/mTOR
attenuating
damage,
inflammatory
response,
regulating
cellular
autophagy.
Therefore,
this
paper
provides
review
protective
effect
against
toxicity
its
molecular
mechanism,
discusses
safety
potential
clinical
applications
search
detoxification
agents.
Cardiology Research and Practice,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Myocardial
ischemia‐reperfusion
(I/R)
injury
is
a
significant
area
of
focus
in
cardiovascular
disease
research.
I/R
can
increase
intracellular
oxidative
stress,
leading
to
DNA
damage.
H2AX
plays
crucial
role
repair.
This
study
utilized
mouse
and
cell
models
myocardial
investigate
the
impact
on
cardiomyocytes
during
I/R.
initially
assessed
expression
MI/R
mice
compared
sham
surgery
group.
Subsequently,
cardiac
function,
infarct
area,
mitochondrial
damage
were
evaluated
after
inhibiting
negative
control
Furthermore,
delved
into
molecular
mechanisms
by
analyzing
H2AX,
P53,
p‐JNK,
SHP2,
p‐SHP2,
p‐RAS,
parkin,
Drp1,
Cyt‐C,
Caspase‐3,
Caspase‐8
following
addition
JNK
or
P53
agonists.
The
results
from
western
blotting
vivo
indicated
significantly
higher
group
Inhibiting
improved
reduced
mitigated
In
vitro
experiments
demonstrated
that
could
attenuate
apoptosis
cells
modulating
signaling
pathways.
These
findings
suggested
may
alleviate
through
regulation
P53/JNK
pathway,
highlighting
as
potential
target
for
treatment
ischemia/reperfusion
injury.
