Neuroprotective insights into epigallocatechin gallate (EGCG) for neurodegenerative disorders

Exploration of neuroscience, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

Neurodegenerative disorders, including Alzheimer’s, Parkinson’s, Huntington’s, and amyotrophic lateral sclerosis, are among the most significant health concerns worldwide, characterized by neuronal dysfunction, oxidative stress, neuroinflammation, protein misfolding. Epigallocatechin gallate, a green tea polyphenol, has been reported to possess multifaceted neuroprotective properties. It reduces stress through free radical scavenging, activation of antioxidant enzymes, stabilization mitochondrial function. also inhibits neuroinflammation modulation key signaling pathways. suppresses amyloid-beta aggregation in Alzheimer’s alpha-synuclein fibrillation thus attenuating toxic accumulation. Its activity induction autophagy promotion synaptic plasticity supports survival However, low bioavailability metabolic instability hinder its translation into clinic. Strategies nanoparticle encapsulation, structural modifications, combination therapies being explored overcome these challenges. Future research could establish epigallocatechin gallate as viable candidate for managing neurodegenerative disorders.

Язык: Английский

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Natural variation in promoters of F3′5′H and ANS correlates with catechins diversification in Thea species of genus Camellia

The Plant Journal, Год журнала: 2025, Номер 121(6)

Опубликована: Март 1, 2025

SUMMARY Catechins were diversely accumulated in Thea plants and crucial for tea flavor, yet the mechanism underlying diverse catechins distribution remained elusive. We herein collected a total of 19 12 non‐ to investigate their mechanism. Results showed that pattern cultivated significantly differs from wild relatives. (+)‐Gallocatechin gallate (GCG) was detected over 50% but almost undetectable plants. Conversely, (−)‐Epigallocatechin (EGCG) extensively distributed cultivars extremely low few relatives such as Camellia tetracocca C. ptilophylla . Expression analysis found expression flavonoid 3′,5′‐hydroxylase ( F3′5′H ) highly correlated with EGCG accumulation Yeast one‐hybrid luciferase assays CsMYB1, key regulator, could bind promoter activate its promote plants; it unable due 14‐bp deletion promoter, leading content EGCG. also silencing anthocyanidin synthase ANS enhanced metabolic flux toward GCG not plants, consistent observation high expression. Overall, results illustrated variation would help facilitate utilization future breeding.

Язык: Английский

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The distribution of catechins and their derivatives among 114 Camellia plants and their correlation in different species and tea-processing suitability

Food Chemistry X, Год журнала: 2025, Номер 27, С. 102461 - 102461

Опубликована: Апрель 1, 2025

China is rich in tea germplasm resources. Catechins and their derivatives were analyzed regarding associations among species tea-processing suitability using 114 representative Camellia plants. GCG, ECG, EGC, ECG3″Me, EGCG revealed as potentially useful markers for identifying different species, while three O-methylated catechins may be appropriate determining the of oolong tea. A correlation analysis indicated that EGCG3″Me content was significantly higher varieties suitable than black green teas. Catechin (C, GC, CG, GCG) contents ptilophylla Chang sinensis var. sinensis, assamica, pubilimba Chang. Furthermore, 14 specific tree resources with a high catechin index EGCG, screened. This research enhances our understanding

Язык: Английский

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MYB transcription factors regulate O-methylated EGCG biosynthesis in different leaf positions of tea plants (Camellia sinensis)

Industrial Crops and Products, Год журнала: 2025, Номер 230, С. 121079 - 121079

Опубликована: Апрель 26, 2025

Язык: Английский

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Innovative and sustainable catechin-based nanocomposites for enhancing salinity tolerance and secondary metabolite production in Stevia rebaudiana (Bertoni) Bertoni

Industrial Crops and Products, Год журнала: 2025, Номер 231, С. 121134 - 121134

Опубликована: Май 13, 2025

Язык: Английский

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Peroxynitrite is essential for aerenchyma formation in rice roots under waterlogging conditions

Planta, Год журнала: 2023, Номер 258(1)

Опубликована: Май 20, 2023

Язык: Английский

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The effect of epigallocatechin-3-gallate (EGCG), a main active ingredient in tea residues, on improving fruit quality and prolonging postharvest storage in apple

Scientia Horticulturae, Год журнала: 2023, Номер 326, С. 112782 - 112782

Опубликована: Дек. 19, 2023

Язык: Английский

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Exogenous Epigallocatechin-3-Gallate Alleviates Pesticide Phytotoxicity and Reduces Pesticide Residues by Stimulating Antioxidant Defense and Detoxification Pathways in Melon

Journal of Plant Growth Regulation, Год журнала: 2023, Номер 43(2), С. 434 - 444

Опубликована: Сен. 4, 2023

Язык: Английский

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Coumarin regulated redox homeostasis to facilitate phytoremediation of saline and alkaline soils by bitter gourd (Momordica charantia L.)

Environmental Science and Pollution Research, Год журнала: 2023, Номер 30(44), С. 99584 - 99604

Опубликована: Авг. 24, 2023

Язык: Английский

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Study of the Physiological Behavior of Some Plants in Response to Climate Change Conditions

Polish Journal of Environmental Studies, Год журнала: 2024, Номер 33(4), С. 3733 - 3745

Опубликована: Апрель 9, 2024

In the context of addressing climate change, it becomes essential to anticipate how will affect plant biodiversity and way plants adapt physiologically morphologically challenging environmental circumstances.To gain a comprehensive understanding adverse climatic conditions, we conducted year-long study with three distinct water stress levels: 25% (sample 1), 50% 2), 75% 3).The findings revealed general decrease in primary metabolites (including proteins, carbohydrates, dietary fiber, lipids, minerals like Mg, Fe, K, Mn) as level increased.In contrast, secondary (such alkaloids, flavonoids, saponins, tannins, coumarins) exhibited an increase rising stress, although decline became evident conditions worsened.The same trend was observed oil yield.Furthermore, gas chromatography analysis oils from indicated significant alterations their chemical composition due influence stressful conditions.

Язык: Английский

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