Global Trends and Hotspots in Research on the Health Risks of Organophosphate Flame Retardants: A Bibliometric and Visual Analysis

Toxics, Год журнала: 2024, Номер 12(6), С. 391 - 391

Опубликована: Май 27, 2024

Background: Organophosphate flame retardants (OPFRs) are compounds with a wide range of industrial and commercial applications mainly used as plasticizers. The global consumption OPFRs has risen rapidly in recent decades, they have been widely detected environmental media. Unfortunately, associated many adverse health outcomes. issue the risks is attracting increasing attention. Therefore, there need to review current state research trends this field help researchers policymakers quickly understand field, identify new directions, allocate appropriate resources for further development OPFR risk field. Methods: This study statistically analyzed 1162 relevant publications included Web Science Core Collection from 2003–2023. internal external features literature, such publication trends, countries, authors, journals, keywords, were quantitatively visually presented hotspots, compositions, paradigms horizontally vertically analyze structural evolution Results: can be divided into three stages, entered period rapid 2016. China (649 papers) most prolific country, followed by United States (188 papers). authors STAPLETON HM WANG Y highest combined impact. International collaboration between countries still needs strengthened. Total Environment frequently published journal (162 papers), Environmental Technology cited (5285 citations). Endocrine disruption, developmental toxicity, neurotoxicity effects greatest interest. Conclusions: Future expected multidisciplinary, hotspots may involve comprehensive assessment exposure population, exploration mechanisms endocrine-disrupting vivo metabolic processes, examination metabolites.

Язык: Английский

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A global survey of organophosphate esters and their metabolites in milk: Occurrence and dietary intake via milk consumption

Journal of Hazardous Materials, Год журнала: 2022, Номер 442, С. 130080 - 130080

Опубликована: Сен. 30, 2022

Язык: Английский

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Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment

Environmental Science & Technology, Год журнала: 2022, Номер 56(12), С. 7905 - 7916

Опубликована: Май 18, 2022

Human exposure to per- and polyfluoroalkyl substances (PFASs) has gained worldwide attention due their widespread presence in the environment adverse health effects, but assessment elderly is still lacking. This study aimed assess exposures 3 emerging PFASs (chlorinated ether sulfonic acids, Cl-PFESAs) 15 legacy PFASs. The temporal variability of internal intake amounts these were evaluated among a population 76 healthy adults (age: 60-69) Jinan, China over 5 consecutive months. Fifteen detected whole blood with mean total concentration (ΣPFAS) at 20.1 ng/mL (range: 5.0-135.9 ng/mL) dominated by perfluorooctanoic acid (PFOA) (9.0 ng/mL), perfluorooctanesulfonic (PFOS) (5.3 6:2 Cl-PFESA (1.6 ng/mL). Across month period, significant variation was only observed for short-chain (C4-C7) perfluoroalkyl carboxylic variations ranged from 53 334%. median PFOA PFOS estimated be 1.46 0.92 ng/kg bw/day, respectively. Regression analysis showed that dietary ingestion, especially fish, likely an important pathway adults. Various pathways (e.g., dietary, water, air, dust) should thus considered fully understand human

Язык: Английский

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Revelations to indoor air pollutants and health risk assessment on women: A case study

Hygiene and Environmental Health Advances, Год журнала: 2022, Номер 5, С. 100038 - 100038

Опубликована: Ноя. 19, 2022

Household air pollution has been identified as a global threat in recent decades. The partial combustion of solid fuel is leading reason for indoor middle- and low-income countries estimated to cause around 3.5 million death per year globally. Women become the most vulnerable these household due their exceptional physical possessions higher exposure duration. current study aims identify possible conditions women. starts with questionnaire survey assess health-related issues distinguishing women further sampling pollutants kitchen area different homes (n=10) bifurcated on basis nature family. Further, concentration obtained was utilized health risk assessment using ICRP MPPD modelling techniques. trend observed shows particulate matter joint family kitchens. According highest deposition determined PM2.5 fraction distributed 55.9% head region, 6.7% tracheobronchial region 37.2% pulmonary region. lowest PM0.5 (61.1%) followed by region(21.45%) (17.3%). Precisely, present gives clear picture about lung an setting specifically Also, it throws light upon sources scenarios regarding prevailing among population.

Язык: Английский

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Organophosphate esters (OPEs) in a coral reef food web of the Xisha Islands, South China Sea: Occurrence, trophodynamic, and exposure risk

Chemosphere, Год журнала: 2022, Номер 313, С. 137652 - 137652

Опубликована: Дек. 26, 2022

Язык: Английский

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Impact of Exposure to a Mixture of Organophosphate Esters on Adrenal Cell Phenotype, Lipidome, and Function

Endocrinology, Год журнала: 2024, Номер 165(4)

Опубликована: Фев. 17, 2024

Abstract Organophosphate esters (OPEs) are used primarily as flame retardants and plasticizers. Previously, we reported that adrenal cells important targets of individual OPEs. However, real-life exposures to complex mixtures these chemicals. To address this, exposed H295R human varying dilutions (1/1000K 1/3K) a Canadian household dust–based OPE mixture for 48 hours evaluated effects on phenotypic, lipidomic, functional parameters. Using high-content screening approach, assessed phenotypic markers at concentrations which there was greater than 70% cell survival; the most striking effect 2.5-fold increase in total area lipid droplets. We then determined response specific species with novel, nontargeted lipidomic analysis isolated These data revealed house dust OPEs induced concentration-dependent alterations composition droplets, particularly affecting triglyceride, diglyceride, phosphatidylcholine, cholesterol ester subclasses. The steroid-producing function presence or absence steroidogenic stimulus, forskolin, determined. While production 17β-estradiol remained unaffected, slight decrease testosterone observed after stimulation. Conversely, 2-fold both basal stimulated cortisol aldosterone observed. Thus, exposure exerts endocrine-disrupting cells, highlighting importance assessing environmentally relevant mixtures.

Язык: Английский

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Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study

Environmental Health Perspectives, Год журнала: 2024, Номер 132(9)

Опубликована: Сен. 1, 2024

Environmental contaminants (ECs) are increasingly recognized as crucial drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact spectrum interlinking mechanisms remain uncertain.

Язык: Английский

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Personal PM_2.5 Elemental Components, Decline of Lung Function, and the Role of DNA Methylation on Inflammation-Related Genes in Older Adults: Results and Implications of the BAPE Study

Environmental Science & Technology, Год журнала: 2022, Номер 56(22), С. 15990 - 16000

Опубликована: Окт. 10, 2022

Epidemiological evidence of the effects PM2.5 elements on lung function and DNA methylation is limited. We conducted a longitudinal panel study 76 healthy older adults aged 60–69 years in Jinan, China, from September 2018 to January 2019. periodically measured individual 72 h element concentrations, function, levels eight inflammation-related genes. used linear mixed-effect models investigate exposure personal methylation. Mediation analysis was underlying effect mechanism. Negative changes ratio forced expiratory volume 1 s vital capacity, ranging −1.23% [95% confidence interval (CI): −2.11%, −0.35%] −0.77% (95% CI: −1.49%, −0.04%), were significantly associated with interquartile range (IQR) increases at different lag periods (7–12, 13–24, 25–48, 0–24, 0–48, 0–72 h). Arsenic (As), nickel, rubidium (Rb), selenium, vanadium least three parameters, IQR these led 0.12–5.66% reductions parameters. levels. mediated 7.28–13.02% As- Rb-related reduced function. The findings indicate that contributes through

Язык: Английский

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Organophosphate esters in Chinese rice: Occurrence, distribution, and human exposure risks

The Science of The Total Environment, Год журнала: 2022, Номер 862, С. 160915 - 160915

Опубликована: Дек. 12, 2022

Язык: Английский

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Co-occurrence and distribution of organophosphate tri- and di-esters in dust and hand wipes from an e-waste dismantling plant in central China

The Science of The Total Environment, Год журнала: 2023, Номер 878, С. 163176 - 163176

Опубликована: Март 31, 2023

Язык: Английский

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