Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(9)

Published: Sept. 1, 2024

Environmental contaminants (ECs) are increasingly recognized as crucial drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact spectrum interlinking mechanisms remain uncertain.

Language: Английский

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Emerging and Legacy Per- and Polyfluoroalkyl Substances in an Elderly Population in Jinan, China: The Exposure Level, Short-Term Variation, and Intake Assessment

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(12), P. 7905 - 7916

Published: May 18, 2022

Human exposure to per- and polyfluoroalkyl substances (PFASs) has gained worldwide attention due their widespread presence in the environment adverse health effects, but assessment elderly is still lacking. This study aimed assess exposures 3 emerging PFASs (chlorinated ether sulfonic acids, Cl-PFESAs) 15 legacy PFASs. The temporal variability of internal intake amounts these were evaluated among a population 76 healthy adults (age: 60-69) Jinan, China over 5 consecutive months. Fifteen detected whole blood with mean total concentration (ΣPFAS) at 20.1 ng/mL (range: 5.0-135.9 ng/mL) dominated by perfluorooctanoic acid (PFOA) (9.0 ng/mL), perfluorooctanesulfonic (PFOS) (5.3 6:2 Cl-PFESA (1.6 ng/mL). Across month period, significant variation was only observed for short-chain (C4-C7) perfluoroalkyl carboxylic variations ranged from 53 334%. median PFOA PFOS estimated be 1.46 0.92 ng/kg bw/day, respectively. Regression analysis showed that dietary ingestion, especially fish, likely an important pathway adults. Various pathways (e.g., dietary, water, air, dust) should thus considered fully understand human

Language: Английский

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A global survey of organophosphate esters and their metabolites in milk: Occurrence and dietary intake via milk consumption

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 442, P. 130080 - 130080

Published: Sept. 30, 2022

Language: Английский

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Personal PM_2.5 Elemental Components, Decline of Lung Function, and the Role of DNA Methylation on Inflammation-Related Genes in Older Adults: Results and Implications of the BAPE Study

Environmental Science & Technology, Journal Year: 2022, Volume and Issue: 56(22), P. 15990 - 16000

Published: Oct. 10, 2022

Epidemiological evidence of the effects PM2.5 elements on lung function and DNA methylation is limited. We conducted a longitudinal panel study 76 healthy older adults aged 60–69 years in Jinan, China, from September 2018 to January 2019. periodically measured individual 72 h element concentrations, function, levels eight inflammation-related genes. used linear mixed-effect models investigate exposure personal methylation. Mediation analysis was underlying effect mechanism. Negative changes ratio forced expiratory volume 1 s vital capacity, ranging −1.23% [95% confidence interval (CI): −2.11%, −0.35%] −0.77% (95% CI: −1.49%, −0.04%), were significantly associated with interquartile range (IQR) increases at different lag periods (7–12, 13–24, 25–48, 0–24, 0–48, 0–72 h). Arsenic (As), nickel, rubidium (Rb), selenium, vanadium least three parameters, IQR these led 0.12–5.66% reductions parameters. levels. mediated 7.28–13.02% As- Rb-related reduced function. The findings indicate that contributes through

Language: Английский

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Revelations to indoor air pollutants and health risk assessment on women: A case study

Hygiene and Environmental Health Advances, Journal Year: 2022, Volume and Issue: 5, P. 100038 - 100038

Published: Nov. 19, 2022

Household air pollution has been identified as a global threat in recent decades. The partial combustion of solid fuel is leading reason for indoor middle- and low-income countries estimated to cause around 3.5 million death per year globally. Women become the most vulnerable these household due their exceptional physical possessions higher exposure duration. current study aims identify possible conditions women. starts with questionnaire survey assess health-related issues distinguishing women further sampling pollutants kitchen area different homes (n=10) bifurcated on basis nature family. Further, concentration obtained was utilized health risk assessment using ICRP MPPD modelling techniques. trend observed shows particulate matter joint family kitchens. According highest deposition determined PM2.5 fraction distributed 55.9% head region, 6.7% tracheobronchial region 37.2% pulmonary region. lowest PM0.5 (61.1%) followed by region(21.45%) (17.3%). Precisely, present gives clear picture about lung an setting specifically Also, it throws light upon sources scenarios regarding prevailing among population.

Language: Английский

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Organophosphate esters (OPEs) in a coral reef food web of the Xisha Islands, South China Sea: Occurrence, trophodynamic, and exposure risk

Chemosphere, Journal Year: 2022, Volume and Issue: 313, P. 137652 - 137652

Published: Dec. 26, 2022

Language: Английский

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Co-occurrence and distribution of organophosphate tri- and di-esters in dust and hand wipes from an e-waste dismantling plant in central China

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 163176 - 163176

Published: March 31, 2023

Language: Английский

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Organophosphate ester flame retardants in sediments and marine fish species in Colombia: Occurrence, distribution, and implications for human risk assessment

Marine Pollution Bulletin, Journal Year: 2025, Volume and Issue: 213, P. 117654 - 117654

Published: Feb. 8, 2025

Exposure to organophosphate esters (OPEs) remains a significant concern, especially in aquatic systems where these compounds can bioaccumulate organisms. However, limited information exists regarding their potential health risks humans through the food web tropical ecosystems. This study investigated levels, bioaccumulation, and trophic transfer of OPEs sediments marine fish species from Cartagena Barbacoas bays, Colombia. Twenty target were quantified fish. The average concentrations ∑18OPEs ranged 2.80 115 ng/g dry weight (dw), while ∑20OPE 212 1968 lipid (lw), with highest found carnivorous species. Trophic magnification factors (TMF) for varied 11.0 25.8 such as 2-ethylhexyl diphenyl phosphate (EHDPP), 4-isopropylphenyl (4IPPDPP), tris(2-isopropylphenyl) (T2IPPP), tricresylphosphate (TCP), indicating biomagnification within web. Biota-sediment accumulation (BSAF) ∑11OPEs 0.340 4.32, showing Spearman correlation log Kow fish: Pargo chino (r = -0.78, p < 0.05), Mojarra blanca 0.79, Lisa 0.72, 0.05). suggests that bioaccumulation certain increase lipophilicity compounds. Despite findings, human risk OPE exposure via consumption was be minimal.

Language: Английский

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Identification of the associations between co-exposure to organophosphate flame retardants and thyroid dysfunction and exposure risk factors in residents of Shanghai, China

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 125911 - 125911

Published: Feb. 1, 2025

Language: Английский

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Chemical exposure in females of childbearing age associated with sex hormones: Evidence from an untargeted exposomic approach

Environment International, Journal Year: 2025, Volume and Issue: 197, P. 109362 - 109362

Published: March 1, 2025

Language: Английский

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