The Science of The Total Environment, Год журнала: 2024, Номер 923, С. 171495 - 171495
Опубликована: Март 5, 2024
Язык: Английский
The Science of The Total Environment, Год журнала: 2024, Номер 923, С. 171495 - 171495
Опубликована: Март 5, 2024
Язык: Английский
The Science of The Total Environment, Год журнала: 2023, Номер 869, С. 161836 - 161836
Опубликована: Янв. 28, 2023
Язык: Английский
Процитировано
114Journal of Hazardous Materials, Год журнала: 2023, Номер 452, С. 131245 - 131245
Опубликована: Март 21, 2023
Язык: Английский
Процитировано
104Environmental Science & Technology Letters, Год журнала: 2022, Номер 9(12), С. 1050 - 1055
Опубликована: Ноя. 7, 2022
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine-quinone, also known as 6PPD-quinone (6PPD-Q), was recently identified the toxic chemical that causes acute mortality in coho salmon following exposure to urban road runoff. Subsequent studies found there were large differences sensitivity 6PPD-Q (>100-fold) even among salmonid species. Here we performed 96 h toxicity tests of with three species (Salvelinus leucomaenis pluvius, Salvelinus curilus, and Oncorhynchus masou masou) lethally S. pluvius a 24 median lethal concentration (LC50) 0.51 μg/L but not other two at environmentally relevant concentrations (<3.8 μg/L). In addition, measured suspected monohydroxylated metabolite brain gill tissues for The internal (ILC50) estimated be 4.0 μg/kg wet weight 6.2 while tissue surviving exceeded ILC50 values pluvius. These results suggest might affected by toxicodynamic factors well toxicokinetics.
Язык: Английский
Процитировано
92Journal of Hazardous Materials, Год журнала: 2023, Номер 455, С. 131601 - 131601
Опубликована: Май 8, 2023
Язык: Английский
Процитировано
75Environmental Science & Technology, Год журнала: 2023, Номер 57(7), С. 2779 - 2791
Опубликована: Фев. 9, 2023
Recently, roadway releases of
Язык: Английский
Процитировано
65Environmental Science & Technology Letters, Год журнала: 2023, Номер 10(10), С. 815 - 823
Опубликована: Сен. 1, 2023
N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) is a chemical added to tires prevent their oxidative degradation. 6PPD highly reactive with ozone and oxygen, leading the formation of transformation products such as quinone (6PPDQ) on tire surfaces and, subsequently, in road wear particles. 6PPDQ toxicant that has been found roadway runoff receiving water systems. Its presence municipal stormwater led acute mortality coho salmon during migration urban creeks reproduce, generating global interest studying its occurrence toxicity environment. This review aims provide critical overview current state knowledge 6PPDQ, assisting researchers policymakers understanding potential impacts this emerging environment human health. As there are many unanswered questions surrounding further research needed. highlights importance including regulations for 6PPD, well all synthetic chemicals concern.
Язык: Английский
Процитировано
59Environmental Science & Technology, Год журнала: 2023, Номер 57(36), С. 13429 - 13438
Опубликована: Авг. 29, 2023
The rubber antioxidant 6PPD has gained significant attention due to its highly toxic transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of pregnant women, the placental transfer and developmental toxicity 6PPDQ are unknown. Here, we treated C57Bl/6 mice with 4 mg/kg or investigate urine excretion transfer. Female male exhibited sex difference profiles 6PPDQ. Urine concentrations were one order magnitude lower than those 6PPD, suggesting higher bioaccumulation In from embryonic day 11.5 15.5, showed ∼1.5–8 times placenta, embryo body, brain, Using vitro dual-luciferase reporter assays, revealed that activated human retinoic acid receptor α (RARα) retinoid X (RXRα) at as low 0.3 μM, which was ∼10-fold detected urines. RXRα 1.2 μM. These results demonstrate exposure risks during pregnancy emphasize need for further toxicological epidemiological investigations.
Язык: Английский
Процитировано
54The Science of The Total Environment, Год журнала: 2024, Номер 927, С. 171153 - 171153
Опубликована: Март 7, 2024
About 3 billion new tires are produced each year and about 800 million become waste annually. Global dependence upon from natural rubber petroleum-based compounds represents a persistent complex environmental problem with only partial often-times, ineffective solutions. Tire emissions may be in the form of whole tires, tire particles, chemical compounds, which is transported through various atmospheric, terrestrial, aquatic routes built environments. Production use generates multiple heavy metals, plastics, PAH's, other that can toxic alone or as cocktails. Used require storage space, energy intensive to recycle, generally have few post-wear uses not also potential sources pollutants (e.g., crumb rubber, pavements, burning). particles emitted during major component microplastics urban runoff source unique highly potent substances. Thus, represent ubiquitous pollutant requires comprehensive examination develop effective management remediation. We approach issue pollution holistically by examining life cycle across production, emissions, recycling, disposal. In this paper, we synthesize recent research data human health risks associated use, disposal discuss gaps our knowledge fate transport, well toxicology leachates. examine remediation approaches for addressing exposure tires. consider three levels: their state, particulates, mixture Finally, information understanding outline key questions improve ability manage remediate pollution.
Язык: Английский
Процитировано
54Journal of Hazardous Materials, Год журнала: 2023, Номер 459, С. 132127 - 132127
Опубликована: Июль 23, 2023
Язык: Английский
Процитировано
51Nature Water, Год журнала: 2024, Номер 2(5), С. 453 - 463
Опубликована: Апрель 25, 2024
Язык: Английский
Процитировано
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