Journal of Hazardous Materials Letters,
Год журнала:
2024,
Номер
5, С. 100109 - 100109
Опубликована: Апрель 3, 2024
Per-
and
polyfluoroalkyl
substances
(PFASs)
have
been
found
in
toilet
paper
Europe,
the
United
States,
Africa;
however,
their
presence
Chinese
household
has
not
investigated.
In
this
study,
21
legacy
30
emerging
PFASs
were
analyzed
tissue
from
China,
including
48
samples
of
different
origins
materials.
Median
concentrations
chlorinated
polyfluorinated
ether
sulfonates
(Cl-PFESAs),
hexafluoropropylene
oxide
homologs
(HFPOs),
p-perfluorous
nonenoxybenzenesulfonate
(OBS)
0.32,
0.19,
0.10
ng/g
dry
weight
(dw),
respectively.
The
detection
frequencies
(DFs)
Cl-PFESAs
OBS
both
greater
than
96%,
followed
by
trimer
acid
(HFPO-TrA,
DF:
85%).
Notably,
level
HFPO-TrA
one
sample
was
as
high
540
dw,
indicating
a
potential
environmental
risk
to
humans.
addition,
significantly
higher
that
(p
<
0.05).
However,
no
significant
differences
observed
materials
origins.
This
suggests
PFASs,
particularly
are
widely
detected
products
across
is
source
landfill
contamination
human
exposure.
Biomedicines,
Год журнала:
2024,
Номер
12(3), С. 693 - 693
Опубликована: Март 20, 2024
The
zebrafish
(Danio
rerio)
has
emerged
as
an
appreciated
and
versatile
model
organism
for
studying
cardiovascular
metabolic
diseases,
offering
unique
advantages
both
basic
research
drug
discovery.
genetic
conservation
between
humans
their
high
fecundity
transparent
embryos
allow
efficient
large-scale
drug-oriented
screening
studies.
Zebrafish
possess
a
simplified
system
that
shares
similarities
with
mammals,
making
them
particularly
suitable
modeling
various
aspects
of
heart
development,
function,
disease.
transparency
enables
the
real-time
visualization
dynamics,
insights
into
early
embryonic
events
facilitating
study
heart-related
anomalies.
In
research,
provide
cost-effective
platform
obesity,
type
2
diabetes,
hyperlipidemia,
other
disorders.
Their
reproductive
rate
allows
generation
large
cohorts
robust
statistical
analyses,
while
advanced
tools,
such
CRISPR/Cas9,
enable
precise
gene
editing
which
to
specific
mutations
associated
human
diseases.
models
have
been
instrumental
in
elucidating
molecular
mechanisms
underlying
effects
environmental
factors,
identifying
potential
therapeutic
targets.
Additionally,
permeability
small
molecules
facilitates
discovery
screening,
rapid
economical
approach
compounds
potential.
conclusion,
disease
continue
contribute
significantly
our
perception
pathogenesis,
providing
translational
developing
novel
interventions.
versatility,
scalability,
manipulability
position
invaluable
asset
unraveling
complexities
This
review
presents
overview
model’s
key
features
contributions
investigating
We
discuss
benefits
drawbacks
using
critical
findings
revealed
by
progress
this
endeavor
date.
Environment International,
Год журнала:
2024,
Номер
187, С. 108687 - 108687
Опубликована: Апрель 23, 2024
The
biotoxicity
of
perfluoroalkyl
and
polyfluoroalkyl
substances
(PFASs)
to
aquatic
organisms
has
been
widely
concerned.
However,
studies
on
toxic
effects
PFASs
are
usually
evaluated
directly
by
using
laboratory
exposure
rather
than
validation
based
data
obtained
in
the
field.
In
this
study,
wild
catfish
(Silurus
meridinalis)
was
explored
relationship
between
bioaccumulation
lipid
disorders.
Nine
thirteen
metabolites
were
significantly
associated
with
perfluorooctane
sulfonate
(PFOS)
6:2/8:2Cl-PFESA
(trade
name
F-53B)
exposures,
respectively;
correlated
fatty
acid
(FA)
conjugates,
FA
esters,
steroids,
glycerophosphate
subclasses.
metabolism
fish
its
mechanism
further
analyzed
through
experiments.
Zebrafish
(Danio
rerio)
different
sexes
underwent
PFOS
F-53B
exposures
for
21
days
at
100
ng/L
μg/L.
By
determining
gene
expression
levels,
hepatic
contents,
histopathological
change,
adverse
order
male
or
female
μg/L/F-53(−|-)B
>
μg/L
ng/L/F-53(−|-)B
PFOS;
stress
response
more
intensive
that
female.
activated
peroxisome
proliferator-activated
receptor
pathway,
promoting
processes
total
cholesterol
(T-CHO)
transport,
β-oxidation,
synthesis,
finally
induced
T-CHO
transportation
from
blood
into
liver,
then
accelerated
ester
transformation,
CHO
steroids.
Laboratory
experiments
confirmed
field
analysis.
This
study
innovatively
their
mechanisms
highlighting
concerns
regarding
health
risks.
Environmental Science & Technology,
Год журнала:
2024,
Номер
58(21), С. 9314 - 9327
Опубликована: Май 6, 2024
Globally
implemented
ecological
risk
assessment
(ERA)
guidelines
marginalize
hormesis,
a
biphasic
dose–response
relationship
characterized
by
low-dose
stimulation
and
high-dose
inhibition.
The
present
study
illuminated
the
promise
of
hormesis
as
scientific
model
for
ERA
per-
polyfluoroalkyl
substances
(PFAS)
represented
perfluorooctanoic
acid
(PFOA)
perfluorooctanesulfonic
(PFOS).
A
total
266
hormetic
relationships
were
recompiled
from
1237
observations,
covering
30
species
nine
representative
taxonomic
groups.
standardized
amplitudes
followed
log-normal
probability
distribution,
being
subject
to
limits
biological
plasticity
but
independent
stress
inducers.
SHapley
Additive
exPlanations
algorithm
revealed
that
target
endpoint
was
most
important
variable
explaining
amplitudes.
Subsequently,
quantitative
frameworks
established
incorporate
into
predicted
no-effect
concentration
levels,
with
lower
induction
dose
zero-equivalent
point
broader
zone
PFOS.
Realistically,
10,117
observed
concentrations
PFOA
PFOS
gathered
worldwide,
4%
which
fell
within
zones,
highlighting
environmental
relevance
hormesis.
Additionally,
potential
identified
in
other
legacy
emerging
PFAS
well
their
alternatives
mixtures.
Collectively,
it
is
time
concept
studies
facilitate
more
realistic
characterizations.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Perfluorohexane
sulfonic
acid
(PFHxS)
is
extensively
used
in
waterproof
coatings
and
fire-fighting
foams,
several
studies
have
found
it
to
be
a
potential
health
hazard,
but
there
still
unknown
about
its
effects
on
spermatogenesis.
Our
results
showed
that
PFHxS-treated
mice
significant
reproductive
toxicity,
including
decrease
sperm
count
motility,
the
levels
of
sex
hormones
(P
<
0.05).
Concurrently,
structural
abnormalities
are
observed
sperm,
affecting
≈60-75%
those
group.
Additionally,
structure
blood-testis
barrier
(BTB)
damaged
after
PFHxS
treatment,
leading
higher
expression
inflammatory
cytokines
microenvironment
for
Moreover,
proteins
associated
with
mitochondrial
biogenesis,
PTEN-induced
kinase
1
(PINK1)
NADPH
oxidase
4
(NOX4),
dysregulated
testes
treatment.
Based
metabolome
data,
differential
metabolite
3-hydroxybutanoic
identified
group,
which
can
regulate
histone
Kac
levels,
especially
H3K4ac
H3K9ac.
In
summary,
this
study
suggest
mice,
factors
disrupt
function
metabolic
profiles
hinder
progress
gene
transcription
through
Kac,
ultimately
causing
dysfunction.
Environmental Science & Technology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 3, 2025
Per-
and
polyfluoroalkyl
substances
(PFAS)
pose
potential
health
risks
to
lipid
metabolism,
but
the
effects
of
emerging
PFAS
alternatives,
particularly
in
children,
remain
unclear.
This
cross-sectional
study
investigated
association
between
exposure
levels
294
Chinese
children
aged
7-10
years,
analyzing
blood
samples
for
14
profiles,
including
triglycerides
(TG),
total
cholesterol
(TC),
high-density
lipoprotein
(HDL),
low-density
(LDL),
apolipoprotein
A1
(ApoA1),
B
(ApoB).
Exposure
6:2
Cl-PFESA,
PFO4DA,
PFO5DoDA
was
associated
with
higher
TC,
TG,
LDL
levels,
PFO4DA
increasing
TC
by
1.7%
TG
10.7%.
Weighted
quantile
sum
(WQS)
regression
showed
mixed
positively
(0.08,
95%
CI:
0.007,
0.153).
had
highest
weight
(0.468),
(0.327),
(0.57),
ApoA1
(0.243),
ApoB
(0.466),
while
PFMOAA
HDL
(0.332).
Bayesian
Kernel
Machine
Regression
(BKMR)
analysis
confirmed
positive
associations
mixture
LDL,
ApoA1.
Mediation
revealed
that
mtDNAcn
significantly
mediated
exposure's
effect
on
explaining
27.2-74.2%
effect.
These
findings
highlight
need
regulatory
action
address
risks.
