Environment International,
Год журнала:
2025,
Номер
unknown, С. 109421 - 109421
Опубликована: Март 1, 2025
The
environmental
fragmentation
of
plastics
generates
a
mixture
plastic
particles
various
sizes,
which
frequently
co-occur
with
other
mobile
and
persistent
pollutants.
Despite
the
prevalence
such
scenarios,
interaction
between
micro-
nanoplastics
(MNPs)
their
combined
effects
pollutants,
as
highly
toxic
hexavalent
chromium
(Cr(VI)),
remain
almost
entirely
unexplored
in
mammalian
species.
This
study
demonstrated
that
nanoplastic
microplastic
co-aggregate
together
influence
Cr
bioaccumulation
patterns
related
physiological
alterations
rats.
Following
four-week
repeated
intragastric
exposure
Wistar
rats
to
MNPs
Cr(VI),
either
alone
or
combination,
significantly
enhanced
liver,
heart,
brain,
skin.
Under
co-exposure
conditions,
Cr(VI)
was
primary
driver
cellular
observed
blood,
including
shifts
immune
cell
subpopulations
(e.g.,
neutrophils,
lymphocytes)
red
blood
indices,
while
serum
biochemistry
reflected
limited
stress.
per
se
decreased
creatine
kinase
activity
increased
cholesterol
levels.
In
summary,
polystyrene
increase
distribution
bioavailability,
but
does
not
uniformly
exacerbate
toxicity.
Instead,
may
selectively
alter
responses,
emphasizing
need
for
deeper
understanding
potential
health
risks.
Environment International,
Год журнала:
2024,
Номер
188, С. 108736 - 108736
Опубликована: Май 10, 2024
The
presence
of
microplastics
(MPs)
is
increasing
at
a
dramatic
rate
globally,
posing
risks
for
exposure
and
subsequent
potential
adverse
effects
on
human
health.
Apart
from
being
physical
objects,
MP
particles
contain
thousands
plastic-associated
chemicals
(i.e.,
monomers,
chemical
additives,
non-intentionally
added
substances)
captured
within
the
polymer
matrix.
These
are
often
migrating
MPs
can
be
found
in
various
environmental
matrices
food
chains;
health
effects.
In
addition
to
attributes
MPs,
plastic
surfaces
effectively
bind
exogenous
chemicals,
including
pollutants
(e.g.,
heavy
metals,
persistent
organic
pollutants).
Therefore,
act
as
vectors
pollution
across
air,
drinking
water,
food,
further
amplifying
posed
by
exposure.
Critically,
fragmentation
plastics
environment
increases
risk
interactions
with
cells,
available
leach
adsorb
transfer
pollutants.
This
review
proposes
so-called
triple
nexus
approach
comprehensively
map
existing
knowledge
interconnected
particles,
Based
data,
there
large
gap
regard
cumulative
nexus.
Each
component
known
induce
genotoxicity,
inflammation,
endocrine
disruption,
but
about
long-term
inter-individual
lacking.
Furthermore,
not
readily
excreted
organisms
after
ingestion
they
have
been
accumulated
blood,
cardiac
tissue,
placenta,
etc.
Even
though
number
studies
MPs-associated
impacts
rapidly,
this
underscores
that
pressing
necessity
achieve
an
integrated
assessment
MPs'
order
address
future
gaps.
Air Quality Atmosphere & Health,
Год журнала:
2024,
Номер
17(9), С. 2017 - 2033
Опубликована: Апрель 2, 2024
Abstract
Airborne
microplastics
(MPs)
can
be
easily
inhaled
by
humans,
impacting
their
health
as
they
spend
more
than
80%
of
time
indoors,
especially
during
the
pandemic.
Only
a
few
research
studies
have
examined
indoor
MPs
in
micrometer
size
range
using
active
sampling,
and
mainly
concentrated
on
that
are
millimeters
size.
This
study
investigated
composition
airborne
sampling
seven
houses
city
center
northwestern
Turkey
(Eskişehir)
COVID-19
The
visual
identification
showed
presence
different
colored
MPs,
white,
red,
orange,
green,
yellow,
with
shapes
(fibers,
fragments,
films,
lines,
foam,
pellets).
identified
was
between
2.5
327.36
μm.
polymeric
analysis
123
all
samples
22
compositions.
Residents
these
exposed
to
inhalation
estimates
ranging
from
12.03
18.51
MPs/m
3
.
However,
it
also
estimated
humans
inhale
156–240
daily
houses.
dominant
were
polyamide
6,
polyvinyl
chloride,
polypropylene,
ethylene
propylene,
polystyrene,
high-density
polyethylene.
Scanning
electron
microscopy
energy
dispersive
x-ray
elemental
revealed
common
structural
elements,
additives,
or
vectors
added
adsorbed
like
carbon,
oxygen,
fluorine,
magnesium,
silicon,
chlorine,
nitrogen,
aluminum.
These
environments
prone
MP
pollution.
Still,
level
varies
due
characteristics
environments,
activities
number
occupants/people
space,
etc.
smaller
highlight
necessity
for
standardized
techniques
collection.
Environments,
Год журнала:
2025,
Номер
12(1), С. 10 - 10
Опубликована: Янв. 3, 2025
Microplastic
exposure
has
become
unavoidable,
leading
to
their
presence
in
living
organisms.
One
area
of
particular
concern
is
the
genotoxicity
microplastics,
which
implications
for
reproductive
health
and
cancer
development.
This
review
aims
highlight
genotoxic
effects
microplastics
on
different
organisms,
focusing
impacts
chromosomes,
DNA,
gene
expression.
More
than
85
papers,
primarily
published
last
five
years,
have
been
reviewed.
indicates
that
can
cause
clastogenesis
aneugenesis
at
chromosome
level.
Clastogenesis
results
damage,
while
leads
failures
segregation
without
causing
direct
damage.
Additionally,
fracture
damage
DNA.
These
arise
from
(1)
through
interactions
with
associated
proteins;
(2)
indirect
due
production
reactive
oxygen
species
(ROS)
by
oxidative
stress
induced
microplastics.
Microplastics
trigger
activation
genes
related
inflammatory
response,
increased
ROS
production.
Furthermore,
they
may
alter
expression
other
biological
processes.
The
linked
stem
particles
themselves
chemicals,
it
appears
be
both
size-
dose-dependent.
Cells,
Год журнала:
2024,
Номер
13(21), С. 1788 - 1788
Опубликована: Окт. 29, 2024
Microplastics
and
nanoplastics
(MNPs)
are
ubiquitous
environmental
contaminants.
Their
prevalence,
persistence,
increasing
industrial
production
have
led
to
questions
about
their
long-term
impact
on
human
animal
health.
This
narrative
review
describes
the
effects
of
MNPs
oxidative
stress,
inflammation,
aging.
Exposure
leads
increased
reactive
oxygen
species
(ROS)
across
multiple
experimental
models,
including
cell
lines,
organoids,
systems.
ROS
can
cause
damage
cellular
macromolecules
such
as
DNA,
proteins,
lipids.
Direct
interaction
between
immune
cells
or
an
indirect
result
stress-mediated
may
lead
pro-inflammatory
cytokines
throughout
different
MNP-exposure
conditions.
inflammatory
response
is
a
common
feature
in
pathogenesis
neurodegenerative,
cardiovascular,
other
age-related
diseases.
also
act
senescence
inducers
by
promoting
mitochondrial
dysfunction,
impairing
autophagy,
activating
DNA
responses,
exacerbating
aging
altogether.
Increased
reproductive
transfer
MNPs/induced
damages
from
parents
offspring
animals
further
corroborates
transgenerational
health
risks
tiny
particles.
aims
provoke
deeper
investigation
into
notorious
these
pervasive
particles
well-being
longevity.
Environment International,
Год журнала:
2024,
Номер
186, С. 108638 - 108638
Опубликована: Апрель 1, 2024
Microplastics
(MPs)
are
pervasive
pollutants
in
the
natural
environment
and
contribute
to
increased
levels
of
illness
both
animals
humans.
However,
specific
impacts
MPs
on
skin
damage
alopecia
not
yet
well
understood.
In
this
study,
we
have
examined
effects
two
types
polystyrene
(pristine
aged)
hair
follicle
mice.
UV
irradiation
changed
chemical
physical
properties
aged
MPs,
including
functional
groups,
surface
roughness,
contact
angles.
vivo
vitro
experiments,
cell
injuries
related
oxidative
stress,
apoptosis,
tight
junctions
(TJs),
alopecia,
mitochondrial
dysfunction,
other
damages
were
observed.
Mechanistically,
can
induce
TJs
via
stress
pathway
inhibition
antioxidant-related
proteins,
lead
alopecia.
The
regulation
apoptosis
was
also
observed,
is
involved
ROS-mediated
signaling
pathway.
Importantly,
showed
exacerbated
toxicity,
which
may
be
due
their
elevated
irregularities
altered
compositions.
Collectively,
study
suggests
a
potential
therapeutic
approach
for
caused
by
pollution.
Cancers,
Год журнала:
2024,
Номер
16(21), С. 3703 - 3703
Опубликована: Ноя. 1, 2024
Humans
cannot
avoid
plastic
exposure
due
to
its
ubiquitous
presence
in
the
natural
environment.
The
waste
generated
is
poorly
biodegradable
and
exists
form
of
MPs,
which
can
enter
human
body
primarily
through
digestive
tract,
respiratory
or
damaged
skin
accumulate
various
tissues
by
crossing
biological
membrane
barriers.
There
an
increasing
amount
research
on
health
effects
MPs.
Most
literature
reports
focus
impact
plastics
respiratory,
digestive,
reproductive,
hormonal,
nervous,
immune
systems,
as
well
metabolic
MPs
accumulation
leading
epidemics
obesity,
diabetes,
hypertension,
non-alcoholic
fatty
liver
disease.
xenobiotics,
undergo
ADMET
processes
body,
i.e.,
absorption,
distribution,
metabolism,
excretion,
are
not
fully
understood.
Of
particular
concern
carcinogenic
chemicals
added
during
manufacturing
adsorbed
from
environment,
such
chlorinated
paraffins,
phthalates,
phenols,
bisphenols,
be
released
when
absorbed
body.
continuous
increase
NMP
has
accelerated
SARS-CoV-2
pandemic
there
was
a
need
use
single-use
products
daily
life.
Therefore,
urgent
diagnose
problems
related
MP
detection.
Environment International,
Год журнала:
2024,
Номер
190, С. 108820 - 108820
Опубликована: Июнь 17, 2024
PFAS
are
ubiquitous
industrial
chemicals
with
known
adverse
health
effects,
particularly
on
the
liver.
The
liver,
being
a
vital
metabolic
organ,
is
susceptible
to
PFAS-induced
dysregulation,
leading
conditions
such
as
hepatotoxicity
and
disturbances.
In
this
study,
we
investigated
phenotypic
responses
of
exposure
using
two
hepatocyte
models,
HepG2
(male
cell
line)
HepaRG
(female
line),
aiming
define
alterations,
disturbances
at
metabolite
pathway
levels.
mixture
composition
was
selected
based
epidemiological
data,
covering
broad
concentration
spectrum
observed
in
diverse
human
populations.
Phenotypic
profiling
by
Cell
Painting
assay
disclosed
predominant
effects
mitochondrial
structure
function
both
models
well
F-actin,
Golgi
apparatus,
plasma
membrane-associated
measures.
We
employed
comprehensive
characterization
liquid
chromatography
combined
high-resolution
mass
spectrometry
(LC-HRMS).
dose-dependent
changes
profiles,
lipid,
steroid,
amino
acid
sugar
carbohydrate
metabolism
cells
media,
line
showing
stronger
response.
cells,
most
bile
acids,
acylcarnitines
free
fatty
acids
showed
downregulation,
while
medium-chain
carnosine
were
upregulated,
media
different
response
especially
relation
media.
Importantly,
also
nonmonotonic
for
several
features
metabolites.
On
level,
associated
pathways
indicating
oxidative
stress
inflammatory
responses.
Taken
together,
our
findings
disruptions
hepatocytes
shed
light
potential
mechanisms
contributing
broader
comprehension
PFAS-related
risks.
Ecotoxicology and Environmental Safety,
Год журнала:
2025,
Номер
289, С. 117604 - 117604
Опубликована: Янв. 1, 2025
Plastic
products
contain
complex
mixtures
of
chemical
compounds
that
are
incorporated
into
polymers
to
improve
material
properties.
Besides
the
intentional
additives,
other
including
residual
monomers
and
non-intentionnaly
added
substances
(NIAS)
as
well
sorbed
pollutants
usually
also
present
in
aged
plastic.
Since
most
these
only
loosely
bound
polymer
via
non-covalently
interactions,
i.e.,
van
der
Waals
forces,
they
may
leach
surrounding
environment.
Although
there
is
increasing
knowledge
about
toxicity
weathered
plastic
aquatic
organisms,
little
known
how
associated
chemicals
affect
human
health.
Seafood
consumption
one
routes
exposure
microplastics.
The
aim
this
study
was
evaluate
ability
naturally
induce
harmful
effects
health
MP-contaminated
seafood.
Human
colorectal
adenocarcinoma
Caco-2
hepatocyte
carcinoma
HepG2
cells
were
selected
model
colon
liver
respectively.
They
for
their
high
capacity
metabolize
organic
contaminants.
Both
cell
lines
exposed
DMSO
extracts
different
plastics
investigate
on
viability,
oxidative
stress
induction
genotoxicity.
In
addition,
estrogenic
DMSO-extracts
evaluated
using
an
estrogen-dependent
reporter
gene
assay
T47D-Kbluc
breast
cancer
cells.
Chemical
profiles
polymer-dependent,
with
polyvinyl
chloride
(PVC)
highly
contaminated
metals
while
polypropylene
(PP)
contained
lowest
concentration
metals.
Organic
pollutants,
polycyclic
aromatic
hydrocarbons,
mainly
found
PVC,
density
polyethylene
(HDPE)
PP
extracts,
whereas
extracted
had
less
no
contamination
(polyethylene
terephthalate
PET).
PVC
toxic
inducing
cytotoxicity
both
lines.
DNA
damage
observed
HDPE,
nylon.
Reactive
oxygen
species
induced
nylon
intestinal
No
PET
none
tested
any
effect.
Our
results
demonstrate
some
environmental
released
a
variety
unknown
which
vitro
contribute
adverse
plastics.