Journal of Pharmaceutical and Biomedical Analysis Open,
Год журнала:
2024,
Номер
4, С. 100037 - 100037
Опубликована: Авг. 8, 2024
The
biomedicine
scientific
field
has
made
continuous
progress,
introducing
various
pharmaceutical
compounds
to
enhance
human
life.
While
these
advancements
bring
benefits,
the
unregulated
use
of
raises
concerns,
particularly
regarding
their
presence
in
environment
and
potential
adverse
effects
on
health.
Therefore,
assessment
by
analytical
strategies
is
imperative
for
comprehending
appraising
interactions
across
diverse
matrices.
In
this
sense,
solid-based
microextraction
procedures
have
shed
light
challenging
task
evaluating
complex
samples.
Moreover,
miniaturized
are
firmly
rooted
principles
green
chemistry,
thereby
presenting
more
environmentally
friendly
approaches
than
traditional
extraction
methods.
Consequently,
significant
endeavors
been
undertaken
introduce
novel
sorbent
materials
that
foster
a
selective
interaction
with
target
analytes.
Having
mind,
molecularly
imprinted
polymers
(MIPs)
emerge
as
solution,
providing
binding
sites
capable
interacting
analyte
within
sample.
integration
MIPs
phases
led
strides
advancing
evaluation
different
Hence,
review
offer
comprehensive
overview
current
applications
combined
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Фев. 25, 2022
Contaminants
of
Emerging
Concerns
(CECs)
are
defined
as
chemicals
not
commonly
monitored
in
aquatic
ecosystems,
but
with
the
potential
to
cause
adverse
effects
on
biota.
CECs
include
Endocrine
Disrupting
Chemicals
(EDCs)
and
Neuro-Endocrine
disruptors
(NEDs)
vertebrates.
However,
most
invertebrates
only
rely
neuroendocrine
systems
maintain
homeostatic
processes.
Although
conserved
components
have
been
characterized
ecologically
relevant
groups,
limited
knowledge
invertebrate
neuroendocrinology
makes
it
difficult
define
EDCs
NEDs
species.
The
monoamine
serotonin
(5-hydroxytryptamine,
5-HT)
acts
both
a
neurotransmitter
peripheral
hormone
mammals.
In
molluscs,
5-HT
is
involved
multiple
physiological
roles
molecular
serotonergic
system
identified.
This
review
focused
bivalve
molluscs.
Bivalves
widespread
all
environments,
estuarine
coastal
areas
particular,
where
they
exposed
variety
chemicals.
bivalves,
gametogenesis
spawning,
oocyte
maturation
sperm
motility,
regulates
heart
function,
gill
ciliary
beating,
mantle/siphon
''catch''
state
smooth
muscle
immune
responses.
Components
transduction
(receptors
signaling
pathways)
being
identified
several
Different
shown
affect
system.
particularly
applies
antidepressants,
among
detected
human
pharmaceuticals
environment.
selective
reuptake
inhibitors
(SSRIs)
frequently
seawater
tissues.
Information
available
mechanisms
action
SSRIs
adult
bivalves
summarized.
Data
also
reported
development
pathways
early
larval
stages,
particular
model
marine
mussel
Mytilus
galloprovincialis.
Overall,
data
point
at
sensitive
target
for
disruption
bivalves.
results
contribute
drawing
Adverse
Outcome
Pathways
(AOPs)
larvae
adults.
basic
research
still
needed
evaluate
impact
key
groups
ecosystems.
Frontiers in Microbiology,
Год журнала:
2023,
Номер
14
Опубликована: Июль 12, 2023
The
ability
of
fungal
species
to
produce
a
wide
range
enzymes
and
metabolites,
which
act
synergistically,
makes
them
valuable
tools
in
bioremediation,
especially
the
removal
pharmaceutically
active
compounds
(PhACs)
from
contaminated
environments.
PhACs
are
that
have
been
specifically
designed
treat
or
alter
animal
physiological
conditions
they
include
antibiotics,
analgesics,
hormones,
steroids.
Their
detrimental
effects
on
all
life
forms
become
source
public
outcry
due
their
persistent
nature
uncontrolled
discharge
into
various
wastewater
effluents,
hospital
surface
waters.
Studies
however
shown
fungi
necessary
metabolic
machinery
degrade
complex
environments,
such
as
soil
water,
addition
can
be
utilized
bioreactor
systems
remove
PhACs.
In
this
regard,
review
highlights
with
immense
potential
biodegradation
PhACs,
enzymatic
arsenal
well
probable
mechanism
biodegradation.
challenges
encumbering
real-time
application
promising
bioremediative
approach
also
highlighted,
areas
improvement
future
perspective.
all,
paper
points
researchers
fact
bioremediation
is
strategy
for
addressing
growing
issue
pharmaceutical
contamination
environment
help
mitigate
negative
impacts
ecosystems
human
health.
Angewandte Chemie,
Год журнала:
2024,
Номер
136(40)
Опубликована: Июль 15, 2024
Abstract
The
electro‐Fenton
(EF)
process
is
an
advanced
oxidation
technology
with
significant
potential;
however,
it
limited
by
two
steps:
generation
and
activation
of
H
2
O
.
In
contrast
to
the
production
via
electrochemical
two‐electron
oxygen
reduction
reaction
(ORR),
three‐electron
(3e
−
)
ORR
can
directly
activate
molecular
yield
hydroxyl
radical
(⋅OH),
thus
breaking
through
conceptual
operational
limitations
traditional
EF
reaction.
Therefore,
3e
a
vital
for
efficiently
producing
⋅OH
in
situ,
charting
new
path
toward
development
green
water‐treatment
technologies.
This
review
summarizes
characteristics
mechanisms
ORR,
focusing
on
basic
principles
latest
progress
situ
efficient
utilization
modulation
pathway,
shedding
light
rational
design
catalysts,
mechanistic
exploration,
practical
applications
water
treatment.
Finally,
future
developments
challenges
efficient,
stable,
large‐scale
are
discussed
based
achieving
optimal
regulation
potential
combine
other
Biomolecules,
Год журнала:
2022,
Номер
12(10), С. 1489 - 1489
Опубликована: Окт. 15, 2022
The
worldwide
access
to
pharmaceuticals
and
their
continuous
release
into
the
environment
have
raised
a
serious
global
concern.
Pharmaceuticals
remain
active
even
at
low
concentrations,
therefore
occurrence
in
waterbodies
may
lead
successive
deterioration
of
water
quality
with
adverse
impacts
on
ecosystem
human
health.
To
address
this
challenge,
there
is
currently
an
evolving
trend
toward
search
for
effective
methods
ensure
efficient
purification
both
drinking
wastewater.
Biocatalytic
transformation
using
oxidoreductase
enzymes,
such
as
peroxidase
laccase,
promising
environmentally
friendly
solution
treatment,
where
fungal
species
been
used
preferred
producers
due
ligninolytic
enzymatic
systems.
Enzyme-catalyzed
degradation
can
transform
micropollutants
more
bioavailable
or
innocuous
products.
Enzyme
immobilization
carrier
generally
increases
its
stability
catalytic
performance,
allowing
reuse,
being
approach
applicability
industrial
scale
process.
Moreover,
coupling
biocatalytic
processes
other
treatment
technologies
revealed
be
achieve
complete
removal
pharmaceuticals.
This
review
updates
state-of-the-art
application
oxidoreductases
namely
degrade
from
spiked
real
advances
concerning
techniques
enzyme
immobilization,
operation
bioreactors,
use
redox
mediators,
hybrid
techniques,
well
discussion
mechanisms
ending
toxicity,
are
addressed.
PeerJ,
Год журнала:
2023,
Номер
11, С. e14719 - e14719
Опубликована: Фев. 1, 2023
The
environmental
fate
of
non-steroidal
anti-inflammatory
drugs
(NSAIDs)
in
the
urban
water
cycle
is
still
uncertain
and
their
status
mainly
assessed
based
on
specific
components
information
human
risk
assessments.
This
study
(a)
explores
NSAIDs
(ibuprofen,
IBU;
naproxen,
NAP;
ketoprofen,
KET;
diazepam,
DIA;
diclofenac,
DIC)
cycle,
including
wastewater,
river,
treated
via
gas
chromatography-mass
spectrophotometry
(GCMS),
(b)
assesses
efficiency
reducing
targeted
sewage
treatment
plant
(STP)
using
analysis
variance
(ANOVA),
(c)
evaluates
ecological
assessment
these
teratogenic
index
(TI)
quotient
(RQ).
primary
receptor
contaminants
comes
from
areas,
as
a
high
concentration
detected
(ranging
5.87
×
10
3
to
7.18
4
ng/L).
percentage
removal
STP
ranged
25.6%
92.3%.
NAP
KET
were
at
trace
levels
water,
indicating
persistent
presence
cycle.
TI
values
for
DIA
(influent
effluent)
more
than
1,
showing
effect.
IBU,
KET,
DIC
had
less
lethal
embryo
effects.
can
be
classified
Human
Pregnancy
Category
C
(2.1
>
≥
0.76).
work
proved
that
exist
current
which
could
induce
adverse
effects
humans
environment
(RQ
low-risk
categories).
Therefore,
they
should
minimized,
if
not
eliminated,
sources
pollutant
(
i.e
.,
STPs).
These
pollutants
considered
priority
monitored,
given
focus
to,
listed
guideline
due
Angewandte Chemie International Edition,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 23, 2024
The
electro-Fenton
(EF)
process
is
an
advanced
oxidation
technology
with
significant
potential;
however,
it
limited
by
two
steps:
generation
and
activation
of
H
