Transgenerational effects of bisphenol A on zebrafish reproductive tissues and sperm motility

Reproductive Toxicology, Год журнала: 2022, Номер 109, С. 31 - 38

Опубликована: Март 2, 2022

Язык: Английский

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Transcriptomic profiling reveals the neuroendocrine-disrupting effect and toxicity mechanism of TBBPA-DHEE exposure in zebrafish (Danio rerio) during sexual development

The Science of The Total Environment, Год журнала: 2022, Номер 858, С. 160089 - 160089

Опубликована: Ноя. 9, 2022

Язык: Английский

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Developmental defects in cognition, metabolic and cardiac function following maternal exposures to low environmental levels of selective serotonin re-uptake inhibitors and tributyltin in Daphnia magna

The Science of The Total Environment, Год журнала: 2024, Номер 917, С. 170463 - 170463

Опубликована: Янв. 28, 2024

Aquatic organisms are exposed to low concentrations of neuro-active chemicals, many them acting also as neuroendocrine disruptors that can be hazardous during earlier embryonic stages. The present study aims assess how exposure early in live environmental two selective serotonin reuptake inhibitors (SSRIs), fluoxetine and sertraline, tributyltin (TBT) affected cognitive, metabolic cardiac responses the model aquatic crustacean Daphnia magna. To end, newly brooded females were for an entire reproductive cycle (3–4 days) response collected juveniles first, second third consecutive broods, which exposed, respectively, embryos, provisioned un-provisioned egg stages, was monitored. Pre-exposure selected SSRIs developmental stages altered swimming behaviour D. magna light a similar way reported elsewhere by serotonergic compounds while TBT cognition disrupting multiple neurological signalling routes. studied body size, amount storage lipids lipid droplets, heart rate, oxygen consumption rates transcription related serotonergic, dopaminergic genes new-born individuals, mostly pre-exposed their provisioning obtained defects developed from sensitive pre-natal align with "Developmental Origins Health Disease (DoHAD)" paradigm.

Язык: Английский

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Blood Biochemical Biomarkers in Fish Toxicology—A Review

Animals, Год журнала: 2025, Номер 15(7), С. 965 - 965

Опубликована: Март 27, 2025

Blood-based biochemical assays are used as predictive and diagnostic methods to evaluate fish welfare in aquaculture research. The variations of blood parameters commonly biomarkers exposure toxic agents. Blood can help identify the magnitude toxicity mechanisms by which particular agents act on organisms. Some typically measured also be evaluated whole body early developmental stages (embryos larvae) that often toxicological studies. This review assessed usefulness various indices biomarkers. Analysis multiple studies showed toxicity-induced changes most depend agent concentration duration. Also, manifest different sensitivity intoxication, diverse directions may occur. Among parameters, some general physiological stress, while others indicate dysfunctions organs. Moreover, hormonal endpoints seem sensitive but nonspecific intoxication fish.

Язык: Английский

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Emerging organoid models to study the epididymis in male reproductive toxicology

Reproductive Toxicology, Год журнала: 2022, Номер 112, С. 88 - 99

Опубликована: Июль 8, 2022

Язык: Английский

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