The impact of air pollution on COVID-19 incidence, severity, and mortality: A systematic review of studies in Europe and North America

Environmental Research, Год журнала: 2022, Номер 215, С. 114155 - 114155

Опубликована: Авг. 27, 2022

Язык: Английский

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A review on measurements of SARS-CoV-2 genetic material in air in outdoor and indoor environments: Implication for airborne transmission

The Science of The Total Environment, Год журнала: 2021, Номер 809, С. 151137 - 151137

Опубликована: Окт. 25, 2021

Язык: Английский

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Airborne fine particles drive H1N1 viruses deep into the lower respiratory tract and distant organs

Science Advances, Год журнала: 2023, Номер 9(23)

Опубликована: Июнь 9, 2023

Mounting data suggest that environmental pollution due to airborne fine particles (AFPs) increases the occurrence and severity of respiratory virus infection in humans. However, it is unclear whether how interactions with AFPs alter viral distribution. We report synergetic effects between various H1N1 virus, regulated by physicochemical properties AFPs. Unlike caused alone, facilitated internalization through a receptor-independent pathway. Moreover, promoted budding dispersal progeny virions, likely mediated lipid rafts host plasma membrane. Infected animal models demonstrated favored penetration into distal lung, its translocation extrapulmonary organs including liver, spleen, kidney, thus causing severe local systemic disorders. Our findings revealed key role driving throughout tract beyond. These insights entail stronger air quality management reduction policies.

Язык: Английский

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The effects of contemporaneous air pollution on COVID-19 morbidity and mortality

Journal of Environmental Economics and Management, Год журнала: 2023, Номер 119, С. 102815 - 102815

Опубликована: Апрель 5, 2023

Язык: Английский

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Age, gender, and race differences in nasal morphology: Linking air conditioning and filtration efficiency to disparities in air pollution health outcomes and COVID-19 mortality

Chemosphere, Год журнала: 2025, Номер 377, С. 144358 - 144358

Опубликована: Март 29, 2025

Язык: Английский

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The spread of the omicron variant: Identification of knowledge gaps, virus diffusion modelling, and future research needs

Environmental Research, Год журнала: 2023, Номер 225, С. 115612 - 115612

Опубликована: Март 5, 2023

The World Health Organization (WHO) recognised variant B.1.1.529 of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as a concern, termed "Omicron", on November 26, 2021. Its diffusion was attributed to its several mutations, which allow promoting ability diffuse worldwide and capability in immune evasion. As consequence, some additional serious threats public health posed risk undermine global efforts made last two years control pandemic. In past, works were devoted discussing possible contribution air pollution SARS-CoV-2 spread. However, best authors' knowledge, there are still no dealing with Omicron mechanisms. This work represents snapshot what we know right now, frame an analysis paper proposes use single indicator, commercial trade data, model virus It is proposed surrogate interactions occurring between humans (the transmission mechanism due human-to-human contacts) could be considered for other diseases. allows also explain unexpected increase infection cases China, detected at beginning 2023. quality data analyzed evaluate first time role particulate matter (PM) carrier diffusion. Due emerging concerns associated viruses (such smallpox-like Europe America), approach seems promising spreading.

Язык: Английский

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SARS-CoV-2 detection in aerosol from community indoor environments

Building and Environment, Год журнала: 2024, Номер 261, С. 111723 - 111723

Опубликована: Июнь 7, 2024

Since its emergence, the COVID-19 pandemic has profoundly and extensively affected global health society. Numerous studies have focused on detecting SARS-CoV-2 in air samples collected healthcare indoor spaces, but few analysed presence from other public community spaces. In addition, limited surveyed spaces where it was not known if individuals with were present or had been at time of sampling. This study aimed to determine genetic load aerosol environments prior knowledge infected cases is available Air (N = 497) settings, elderly care homes, educational settings Valencian Community, Spain. RNA extracted N1, N2, E gene fragments quantified using RT-qPCR. detected 8.9 % samples. The highest positivity rates observed hospitals (16.2 %), homes (15.3 primary centres (12.7 %). Concentration N1 positive ranged 4.3–504 gc/m3 (n 10), 6.2–77 8) 5.1–14 7), respectively. genes N2 less frequently generally reported lower concentrations. frequency detection aerosols increased same that population cumulative incidence increased.

Язык: Английский

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Exposure to particulate matter: Direct and indirect role in the COVID-19 pandemic

Environmental Research, Год журнала: 2021, Номер 206, С. 112261 - 112261

Опубликована: Окт. 21, 2021

Knowing the transmission factors and natural environment that favor spread of a viral infection is crucial to stop outbreaks develop effective preventive strategies. This work aims evaluate role Particulate Matter (PM) in COVID-19 pandemic, focusing especially on PM as vector for SARS-CoV-2. Exposure has been related new cases clinical severity people infected by SARS-CoV-2, which can be explained oxidative stress inflammatory response generated these particles when entering respiratory system, well expression ACE-2 cells human hosts. In addition, different authors have detected SARS-CoV-2 RNA sampled both outdoor indoor environments. The results various studies lead hypothesis aerosols emitted an person could deposited other suspended particles, sometimes but anthropogenic origin, form basal PM. However, viability virus not yet demonstrated. Should confirmed transmission, prevention strategies ought adapted, sampling environments become indicator load specific area.

Язык: Английский

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Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework

Journal of Clinical Medicine, Год журнала: 2022, Номер 11(15), С. 4464 - 4464

Опубликована: Июль 31, 2022

Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the and understanding how they mechanistically influence COVID-19. Here, we describe eleven selected (age, sex, genetic factors, lipid disorders, heart failure, gut dysbiosis, diet, vitamin D deficiency, air pollution exposure to chemicals) by applying Adverse Outcome Pathway (AOP), which well-established in regulatory toxicology. framework aims model sequence of events leading an adverse health outcome. Several linear AOPs depicting pathways from binding virus ACE2 up observed have been developed integrated into a network offering unique overview mechanisms underlying disease. As SARS-CoV-2 infectibility activity major starting points inflammatory response central development COVID-19, evaluated those intrinsic extrinsic modulate processes impacting outcomes. Applying this AOP-aligned approach enables identification current knowledge gaps orientating for further research allows propose biomarkers identify high-risk also facilitates expertise synergy different disciplines address public issues.

Язык: Английский

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A Review of Global PM2.5 Exposure Research Trends from 1992 to 2022

Sustainability, Год журнала: 2023, Номер 15(13), С. 10509 - 10509

Опубликована: Июль 4, 2023

Exposure to air pollutants of fine particulate matter (PM2.5) is a major threat human health. Research on PM2.5 exposure has been the rise in recent years, but there lack systematic literature analysis this field. To address research gap, we conducted bibliometric existing publications over past three decades and analyzed current state historical trends using open-access tool, KNIME. Our results show that number increasing at an accelerating rate last 30 years. The authors are primarily from developed nations, such as countries North America, Europe, East Asia, Oceania. Published mainly fields Environmental Sciences Ecology, Sciences, Public, Occupational Health. main hotspots exposure, pollution, PM2.5. trending toward intersection integration multiple subjects. highlight rapid growth PM2.5-related provide insights into structure, impact, interdisciplinary

Язык: Английский

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