Impacts of endocrine disrupting chemicals on reproduction in wildlife and humans

Environmental Research, Год журнала: 2021, Номер 208, С. 112584 - 112584

Опубликована: Дек. 21, 2021

Endocrine disrupting chemicals (EDCs) are ubiquitous in aquatic and terrestrial environments. The main objective of this review was to summarize the current knowledge impacts EDCs on reproductive success wildlife humans. examples selected often include a retrospective assessment over time discern how effects have changed last several decades. Collectively, evidence summarized here within reinforce concept that reproduction humans is negatively impacted by anthropogenic chemicals, with altering endocrine system function. These observations interfering different aspects axis particularly pronounced for species corroborated laboratory-based experiments (i.e. fish, amphibians, birds). Noteworthy, many these same indicators also observed epidemiological studies mammalian Given vast array strategies used animals, it perhaps not surprising no single disrupted target predictive effects. Nevertheless, there some general features control reproduction, particular, critical role steroid hormones play processes confer high degree susceptibility environmental chemicals. New research needed implications chemical exposures during development potential long-term Future emphasis field-based can form basis more deliberate, extensive, population level monitor contaminant effects, including adverse system, key addressing gaps.

Язык: Английский

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Endocrine Disrupting Chemicals’ Effects in Children: What We Know and What We Need to Learn?

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(19), С. 11899 - 11899

Опубликована: Окт. 7, 2022

Thousands of natural or manufactured chemicals were defined as endocrine-disrupting (EDCs) because they can interfere with hormone activity and the endocrine system. We summarize discuss what we know still need to learn about EDCs' pathogenic mechanisms action, well effects most common EDCs on system health in childhood. The MEDLINE database (PubMed) was searched 13 May 2022, filtering for EDCs, diseases, children. are a group compounds high heterogeneity, but usually disrupt by mimicking interfering hormones body's hormonal balance through other mechanisms. Individual studied detail, while humans' "cocktail effect" is unclear. In utero, early postnatal life, and/or pubertal development highly susceptible periods exposure. Human epidemiological studies suggest that affect prenatal growth, thyroid function, glucose metabolism, obesity, puberty, fertility several Further needed clarify which mainly act epigenetic processes. A better understanding human crucial developing future regulatory strategies prevent exposure ensure children today, generations, environment.

Язык: Английский

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Cumulative Exposure to Phthalates and Their Alternatives and Associated Female Reproductive Health: Body Burdens, Adverse Outcomes, and Underlying Mechanisms

Environmental Science & Technology, Год журнала: 2023, Номер 57(22), С. 8189 - 8212

Опубликована: Май 17, 2023

The global birth rate has recently shown a decreasing trend, and exposure to environmental pollutants been identified as potential factor affecting female reproductive health. Phthalates have widely used plasticizers in plastic containers, children's toys, medical devices, their ubiquitous presence endocrine-disrupting already raised particular concerns. Phthalate linked various adverse health outcomes, including diseases. Given that many phthalates are gradually being banned, growing number of phthalate alternatives becoming popular, such di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH), di(2-ethylhexyl) adipate (DEHA), terephthalate (DEHTP), they beginning wide range effects. Studies may disrupt function by altering the estrous cycle, causing ovarian follicular atresia, prolonging gestational which raises concerns about risks. Herein, we summarize effects common different models, levels influence system, on impairment, pregnancy offspring development. Additionally, scrutinize hormone signaling, oxidative stress, intracellular signaling explore underlying mechanisms action health, because these chemicals affect tissues directly or indirectly through endocrine disruption. declining trends capacity ability negatively impact more comprehensive study is needed understand human body mechanisms. These findings an important role improving turn complications during pregnancy.

Язык: Английский

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A Review on Tetrabromobisphenol A: Human Biomonitoring, Toxicity, Detection and Treatment in the Environment

Molecules, Год журнала: 2023, Номер 28(6), С. 2505 - 2505

Опубликована: Март 9, 2023

Tetrabromobisphenol A (TBBPA) is a known endocrine disruptor employed in range of consumer products and has been predominantly found different environments through industrial processes human samples. In this review, we aimed to summarize published scientific evidence on biomonitoring, toxic effects mode action TBBPA humans. Interestingly, an overview various pretreatment methods, emerging detection treatment methods was elucidated. Studies exposure routes humans, combination adsorbent-based treatments degradation are the preliminary phase have several limitations. Therefore, in-depth studies these subjects should be considered enhance accurate body load non-invasive matrix, external levels, optimal design combined techniques, degrading technology TBBPA. Overall, review will improve comprehension humans as well environment, breakthrough for treating waste containing

Язык: Английский

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Development of a Phthalate Environmental Reproductive Health Literacy (PERHL) Scale

Environmental Health Perspectives, Год журнала: 2024, Номер 132(4)

Опубликована: Апрель 1, 2024

Substantial evidence exists linking phthalate exposure to adverse reproductive health outcomes. Current US federal regulations of consumer product chemicals place the onus on individuals mitigate their phthalates, with assumptions sufficient environmental literacy (EHL). Few validated scales for people age exist evaluate phthalate-specific EHL.

Язык: Английский

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Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities

Environmental Research, Год журнала: 2021, Номер 204, С. 111904 - 111904

Опубликована: Авг. 19, 2021

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and involve diverse chemical-receptor interactions that can perturb hormone signaling. The Organization for Economic Co-operation Development has validated several EDC-receptor bioassays to detect endocrine active established guidelines regulatory testing of EDCs. Focus on over past decade been initially directed EATS modalities (estrogen, androgen, thyroid, steroidogenesis) tests exert effects through non-EATS less established. Due recognition EDCs vast their mechanisms action, novel needed capture full scope activity. Here, we highlight need assays discuss major international efforts underway develop such tools purposes, focusing high concern (i.e., retinoic acid, aryl hydrocarbon receptor, peroxisome proliferator-activated glucocorticoid signaling). Two case studies presented with strong evidence amongst animals human disruption associations wildlife disease. This includes metabolic syndrome insulin signaling (case study 1) impact cardiovascular system 2). is relevant as obesity disease represent two most significant health-related crises our time. Lastly, emerging topics related discussed, including crosstalk between axis, complex mixtures containing a variety EDCs, adverse outcome pathways acting mechanisms, models chemicals. Recommendations considerations evaluating proposed. Moving forward, improved understanding will lead integrated strategies be used bodies protect environmental, animal, health from harmful environmental

Язык: Английский

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The mammalian preimplantation embryo: Its role in the environmental programming of postnatal health and performance

Animal Reproduction Science, Год журнала: 2023, Номер 256, С. 107321 - 107321

Опубликована: Авг. 19, 2023

Язык: Английский

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Endocrine disrupting compounds in the baby's world - A harmful environment to the health of babies

The Science of The Total Environment, Год журнала: 2023, Номер 881, С. 163350 - 163350

Опубликована: Апрель 5, 2023

Язык: Английский

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Poisoning Regulation, Research, Health, and the Environment: The Glyphosate-Based Herbicides Case in Canada

Toxics, Год журнала: 2023, Номер 11(2), С. 121 - 121

Опубликована: Янв. 26, 2023

Despite discourse advocating pesticide reduction, there has been an exponential increase in use worldwide the agricultural sector over last 30 years. Glyphosate-Based Herbicides (GBHs) are most widely used pesticides on planet as well Canada, where a total of almost 470 million kilograms declared “active” ingredient glyphosate was sold between 2007 and 2018. GBHs accounted for 58% agriculture Canada 2017. While independent scientific literature harmful health environmental impacts such is overwhelming, only banned 32 ingredients out 531 168 countries, reapproved 2017 until 2032. This article, based interdisciplinary intersectoral research, will analyze how result regulatory captures relevant Canadian agencies by industry, regulation assessment deficient lagging behind other using GBH case basis analysis. It show how, embracing industry narratives biased evidence, being receptive to demands, opaque decision making lack transparency, Health Canada’s Pest Management Regulatory Agency (PMRA) promotes commercial interests imperatives public protection.

Язык: Английский

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Bisphenol A and its potential mechanism of action for reproductive toxicity

Toxicology, Год журнала: 2024, Номер unknown, С. 154040 - 154040

Опубликована: Дек. 1, 2024

Язык: Английский

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