Current Trends in OMICS,
Год журнала:
2023,
Номер
4(1), С. 01 - 16
Опубликована: Ноя. 2, 2023
Heavy
metals
have
an
enduring
presence,
risky
characteristics,
and
the
propensity
to
accumulate
in
environment.
This
is
why
heavy
metal
toxics
are
widely
acknowledged
as
harmful
environmental
pollutants.
damage
both
aquatic
terrestrial
ecosystems,
posing
a
major
risk
environment
human
health.
Four
freshwater
fish
species
namely
Labeo
rohita,
Catla
catla,
Hypophthalmichthys
molitrix,
Ctenopharyngodon
idella
were
focus
of
this
investigation.
study
investigated
potential
genotoxic
effects
lead
(Pb),
copper
(Cu),
cadmium
(Cd)
on
above
through
application
comet
assay
test.
The
exposed
these
at
four
distinct
concentrations
(19%,
24%,
31%,
50%
LC50)
over
course
40
days.
All
varying
degrees,
according
genetic
index,
cumulative
tail
length
comets,
proportion
damaged
cells.
In
contrast
molitrix
had
highest
prevalence
DNA
damage.
current
suggests
that
presence
particular
Pakistan's
ecosystems
may
adverse
effect
country's
species.
Metals
cause
fibroblast
cells
mechanisms
when
present
water,
air,
soil.
Comet
test
has
remarkable
sensitivity
helps
identify
extremely
low
amounts
Out
species,
showed
higher
levels
cells,
compared
others.
experienced
significant
increase
damage,
concentration
LC50.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
273, С. 116126 - 116126
Опубликована: Фев. 21, 2024
Nanopolystyrene
(NP)
and
phoxim
(PHO)
are
common
environmental
pollutants
in
aquatic
systems.
We
evaluated
the
toxic
effects
of
exposure
to
ambient
concentrations
NP
and/or
PHO
intestines
Chinese
mitten
crab
(Eriocheir
sinensis).
Our
study
showed
that
histopathological
changes
were
observed
intestines.
Specifically,
increased
intraepithelial
lymphocytes.
Furthermore,
induced
oxidative
stress,
as
evidenced
by
a
significant
decrease
superoxide
dismutase
activity
(SOD),
peroxidase
(POD),
total
antioxidant
capacity
(T-AOC).
Pro-inflammatory
gene
expression
transcriptome
analysis
demonstrated
intestinal
inflammatory
response.
Transcriptome
results
upregulated
NF-κB
signaling
pathway,
which
is
considered
key
pathway
Additionally,
pro-inflammatory
genes
significantly
after
single
or
PHO,
but
it
exhibited
co-exposure.
The
downregulation
these
co-exposure
group
likely
suggested
mitigated
inflammation
response
E.
sinensis.
Collectively,
our
findings
mainly
at
induces
stress