Abstract
An
important
aspect
of
the
treatment
chronic
cases
diabetes
is
enhancement
insulin
secretion
with
a
decrease
in
intestinal
glucose
absorption.
In
this
study,
prepared
alcoholic
Catharanthus
roseus
flower
extract‐fabricated
zinc
oxide
nanoparticles
(FZNPs)
were
characterized
by
UV–vis
spectrometer,
dynamic
light
scattering
(DLS),
X‐ray
diffraction
(XRD),
and
fourier
transform
infrared
spectroscopy
(FTIR)
instruments
antihyperglycemic
properties
tested
at
molecular
level
silico
method.
The
synthesis
FZNPs
possible,
characterization
report
showed
that
they
have
maximum
optical
361
nm,
small
grain
size
(15.68
nm),
negative
zeta
potential
(hydrophilic
nature).
hexagonal
structure
are
surrounded
several
functional
groups.
result
supports
related
structures,
as
well
Zn
(II)
diisophthalate
vindoline,
good
ADMET
properties.
Zn(II)
lead
interaction
alpha‐glucosidase
has
binding
affinity
‐6.3
kcal/mol,
whereas
vindoline
KATP
‐7.4
kcal/mol.
synthesized
ability
to
inhibit
targets
block
ion
channel
beta
cells.
reduce
absorption
promote
secretion,
so
can
effectively
manage
hyperglycaemic
condition
patients.
International Journal of Pharmaceutics X,
Год журнала:
2024,
Номер
7, С. 100257 - 100257
Опубликована: Май 19, 2024
Studies
have
reported
the
potential
role
of
Boswellic
acids
(BAs),
bioactive
pentacyclic
triterpenes
from
Boswellia
serrata,
in
treating
rheumatoid
arthritis
(RA).
However,
poor
water
solubility
and
limited
oral
absorption
are
restricting
factors
for
its
better
therapeutic
efficacy.
Based
on
these
assumptions,
current
study
set
out
to
develop
naturosomal
delivery
BAs
boost
their
extremely
low
bioavailability,
colloidal
stability,
solubility.
Nanonized
naturosomes
were
developed
subsequently
analyzed
show
physicochemical
functional
features
employing
quality-by-design
approach.
The
analysis
acid
(BSENs)
revealed
a
16
times
improvement
aqueous
compared
BS
extract
(BSE).
zeta
dynamic
light
scattering
findings
BSENs
demonstrated
stability
with
regulated
nano-size
particles.
Additionally,
BSE
(⁓31%),
in-vitro
dissolution
experiments
showed
that
>99%
released
BSENs.
ex-vivo
permeation
BSENs'
(>79%)
significantly
improved
over
BSE's
(⁓20%).
In-vivo
efficacy
studies
using
CFA-prompted
rodents
critical
expansion
body
wt
an
undeniable
reduction
paw
thickness,
volume,
TNF-α
treated
BSEN
control
BSE-treated
group.
These
suggest
can
help
treat
RA
drugs
by
demonstrating
further
clinical
research
validate
significant
improvements.
Polymers and Polymer Composites,
Год журнала:
2025,
Номер
33
Опубликована: Янв. 1, 2025
Wound
dressings
used
in
medical
applications
serve
as
a
protective
barrier
for
wounds,
creating
an
environment
that
promotes
wound
healing.
The
typical
traditional
often
present
challenges,
including
weak
function
and
tendency
to
adhere
wounds.
Therefore,
there
is
critical
need
develop
advanced
dressing
with
strong
antibacterial
properties
can
prevent
the
spread
of
infection
accelerate
healing
process.
To
hydrogels
properties,
silver
nanoparticles
(AgNPs)
derived
from
1
mM
AgNO
3
using
green
catalyst
matcha
tea
extract
(
camellia
sinensis)
were
incorporated
into
chitosan
alginate
This
was
accomplished
by
mixing
nitrate
produce
nanoparticles,
which
then
added
hydrogel
crosslinkers.
synthesized
nanomaterials
characterized
UV-VIS
spectroscopy,
TEM,
EDX,
FTIR,
SEM
techniques.
Their
antimicrobial
efficiency
has
been
evaluated
through
inhibition
zone
assays,
antibiofilm
evaluation
against
P.aeruginosa,
E.
coli,
S.
aureus,
C.albicans,
A.niger,
minimum
inhibitory
concentration
(MIC).
It
found
that,
novel
hydrogel,
infused
AgNPs,
exhibited
superior
water
absorption
retention,
ensuring
moist
while
effectively
absorbing
substantial
exudate.
Additionally,
demonstrated
robust
mechanical
potent
activity.
study
highlights
exceptional
newly
developed
natural
polymer
Ag
anti-inflammatory
action.
Hence,
silver-loaded
proves
be
ideal
material.
Applied Biological Chemistry,
Год журнала:
2024,
Номер
67(1)
Опубликована: Авг. 28, 2024
Abstract
Biopolymers
embedded
with
nanoparticles
of
metal
oxides
(MOs)
demonstrate
a
wide
range
bio-functions.
Chitosan-incorporated
MOs
are
an
interesting
class
support
matrices
for
enhancing
the
biological
function,
compared
to
other
matrices.
Therefore,
importance
this
study
lies
in
exploiting
chitosan
as
carrier
not
one
previous
studies,
but
two
metals
form
nanocomposite
carry
out
several
functions.
The
coprecipitation
approach
was
employed
synthesize
chitosan/Fe
2
O
3
/ZnO-nanocomposite
present
research.
characterization
performed
find
morphology
and
dispersion
properties
/ZnO-nanocomposite.
X-ray
diffraction
(XRD)
investigation
revealed
that
these
were
crystalline.
Fourier
transforms
infrared
(FTIR)
spectrum
bands
viewed
at
400/cm
900/cm,
due
stretching
vibration
Fe
Zn
oxygen
bond.
TEM
showed
20–95
nm
size.
exhibited
inhibitory
potential
against
Staphylococcus
aureus
,
Bacillus
subtilis,
Escherichia
coli
Candida
albicans
inhibition
zones
25
±
0.1,
28
0.2,
27
0.2
mm,
respectively
while
didn’t
inhibited
Aspergillus
niger
.
MIC
value
15.62
0.33
µg/mL
C.
albicans,
B.
subtilis
E.
it
62.50
0.66
Pseudomonas
aeruginosa
Ranged
values
MBC
(15.62
125
1
µg/mL)
attributed
all
tested
bacteria.
Different
concentrations
(25,
50,
75%)
reflected
anti-biofilm
activity
(85.0,
93.2,
96.0%),
(84.88,
92.21,
96.99%),
S.
81.64,
90.52,
94.64%)
P.
aurogenosa
(90.11,
94.43,
98.24%),
respectively.
differences
levels
antimicrobial
activities
may
depend
on
type
examined
microbes.
Antioxidant
recorded
excellent
IC
50
16.06
32.6
using
DPPH
ABTS
scavenging,
Wound
heal
by
achieved
100%
untreated
cells
(76.75%
wound
closer).
cytotoxicity
outcomes
564.32
1.46
normal
WI-38
cells.
Based
findings,
is
very
promising
agent
perform
pharmacological
activities.
