ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(48)
Published: Dec. 1, 2024
Abstract
An
important
aspect
of
the
treatment
chronic
cases
diabetes
is
enhancement
insulin
secretion
with
a
decrease
in
intestinal
glucose
absorption.
In
this
study,
prepared
alcoholic
Catharanthus
roseus
flower
extract‐fabricated
zinc
oxide
nanoparticles
(FZNPs)
were
characterized
by
UV–vis
spectrometer,
dynamic
light
scattering
(DLS),
X‐ray
diffraction
(XRD),
and
fourier
transform
infrared
spectroscopy
(FTIR)
instruments
antihyperglycemic
properties
tested
at
molecular
level
silico
method.
The
synthesis
FZNPs
possible,
characterization
report
showed
that
they
have
maximum
optical
361
nm,
small
grain
size
(15.68
nm),
negative
zeta
potential
(hydrophilic
nature).
hexagonal
structure
are
surrounded
several
functional
groups.
result
supports
related
structures,
as
well
Zn
(II)
diisophthalate
vindoline,
good
ADMET
properties.
Zn(II)
lead
interaction
alpha‐glucosidase
has
binding
affinity
‐6.3
kcal/mol,
whereas
vindoline
KATP
‐7.4
kcal/mol.
synthesized
ability
to
inhibit
targets
block
ion
channel
beta
cells.
reduce
absorption
promote
secretion,
so
can
effectively
manage
hyperglycaemic
condition
patients.
International Journal of Pharmaceutics X,
Journal Year:
2024,
Volume and Issue:
7, P. 100257 - 100257
Published: May 19, 2024
Studies
have
reported
the
potential
role
of
Boswellic
acids
(BAs),
bioactive
pentacyclic
triterpenes
from
Boswellia
serrata,
in
treating
rheumatoid
arthritis
(RA).
However,
poor
water
solubility
and
limited
oral
absorption
are
restricting
factors
for
its
better
therapeutic
efficacy.
Based
on
these
assumptions,
current
study
set
out
to
develop
naturosomal
delivery
BAs
boost
their
extremely
low
bioavailability,
colloidal
stability,
solubility.
Nanonized
naturosomes
were
developed
subsequently
analyzed
show
physicochemical
functional
features
employing
quality-by-design
approach.
The
analysis
acid
(BSENs)
revealed
a
16
times
improvement
aqueous
compared
BS
extract
(BSE).
zeta
dynamic
light
scattering
findings
BSENs
demonstrated
stability
with
regulated
nano-size
particles.
Additionally,
BSE
(⁓31%),
in-vitro
dissolution
experiments
showed
that
>99%
released
BSENs.
ex-vivo
permeation
BSENs'
(>79%)
significantly
improved
over
BSE's
(⁓20%).
In-vivo
efficacy
studies
using
CFA-prompted
rodents
critical
expansion
body
wt
an
undeniable
reduction
paw
thickness,
volume,
TNF-α
treated
BSEN
control
BSE-treated
group.
These
suggest
can
help
treat
RA
drugs
by
demonstrating
further
clinical
research
validate
significant
improvements.
