Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease
Toxicology,
Год журнала:
2025,
Номер
511, С. 154067 - 154067
Опубликована: Янв. 25, 2025
Язык: Английский
Chronic exposure to polystyrene microplastics triggers osteoporosis by breaking the balance of osteoblast and osteoclast differentiation
Toxicology,
Год журнала:
2024,
Номер
510, С. 154017 - 154017
Опубликована: Ноя. 27, 2024
Язык: Английский
Perfluorooctanoic acid and its alternatives disrupt the osteogenesis and osteoclastogenesis balance: Evidence from the effects on cell differentiation process
The Science of The Total Environment,
Год журнала:
2025,
Номер
959, С. 178331 - 178331
Опубликована: Янв. 1, 2025
Язык: Английский
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis
Toxicology,
Год журнала:
2024,
Номер
509, С. 153996 - 153996
Опубликована: Ноя. 10, 2024
Язык: Английский
Perfluorooctanoic acid and perfluorooctane sulfonate inhibit in vitro osteogenesis: possible role of connexin 43-mediated gap-junctional intercellular communication
Archives of Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Язык: Английский
PPARγ-SMAD6 axis-mediated inhibition of osteogenic differentiation is involved in BPS-induced osteoporosis
Environment International,
Год журнала:
2025,
Номер
unknown, С. 109442 - 109442
Опубликована: Апрель 1, 2025
Bisphenol
S
(BPS)
is
extensively
utilized
in
personal
care
products,
foods,
and
paper
raising
growing
concerns
about
its
potential
environmental
hazards.
However,
few
studies
have
reported
the
effects
of
BPS
exposure
on
bone
homeostasis.
In
this
study,
using
data
from
National
Health
Nutrition
Examination
Survey,
we
found
a
negative
correlation
between
urinary
mineral
density
(BMD).
To
further
investigate
underlying
mechanisms,
C57BL/6
mice
were
exposed
to
human-equivalent
dose
for
6
months.
Micro-CT
analysis
demonstrated
reduced
femoral
BMD
mice,
indicating
that
osteoporosis
was
caused
by
chronic
exposure.
RNA-seq
showed
activated
PPARγ
human
primary
mesenchymal
stem
cells
(MSCs).
Additionally,
3D
molecular
docking
confirmed
direct
interaction
PPARγ.
Bioinformatics
identified
SMAD6
as
downstream
target
Mechanistically,
BPS-PPARγ
PPARγ,
promoting
transcription,
which
inhibited
osteogenic
differentiation
MSCs.
High-throughput
virtual
screening
revealed
olodanrigan
effectively
blocked
interaction,
vitro
assays
inhibition
MSCs
induced
BPS.
supplementation
levels,
thereby
reversing
BPS-induced
osteoporosis.
summary,
study
elucidates
role
PPARγ-SMAD6
axis
mediating
highlights
promising
therapeutic
intervention,
offering
new
insights
into
health
risks
posed
targets
treatment.
Язык: Английский
Embryonic exposure to GenX causes reproductive toxicity by disrupting the formation of the blood-testis barrier in mouse offspring
Zhencheng Fan,
Runyang Hong,
Shuhao Li
и другие.
Toxicology,
Год журнала:
2025,
Номер
unknown, С. 154161 - 154161
Опубликована: Апрель 1, 2025
Язык: Английский
Mitigation of PFOA-Induced Developmental Toxicity in Danio rerio by Bacillus subtilis var. natto: Focus on Growth and Ossification
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(9), С. 4261 - 4261
Опубликована: Апрель 30, 2025
Perfluorooctanoic
acid
(PFOA)
is
a
persistent
environmental
contaminant
that
resists
biological
degradation
and
accumulates
in
organisms.
It
disrupts
zebrafish
embryo
development,
affecting
their
heartbeat
rate
locomotion.
Meanwhile,
probiotics
are
known
to
enhance
the
development
ossification
of
embryos.
In
this
study,
we
examined
toxic
effects
PFOA
on
growth
bone
formation
potential
probiotic
Bacillus
subtilis
var.
natto
counteract
its
toxicity.
Larvae
were
exposed
0,
50,
or
100
mg/L
from
hatching
21
days
post-fertilization
(dpf),
with
without
dietary
supplementation
(107
CFU/larva/day),
they
sampled
at
7,
14,
dpf.
exposure
reduced
standard
length
dpf,
while
co-administration
mitigated
these
effects.
Craniofacial
cartilage
defects
appeared
larvae
50
7
14
impaired
Probiotics
counteracted
abnormalities.
also
delayed
ossification,
correlating
downregulation
col10a1a,
runx2b,
cyp26b1,
treatment
restored
normal
ossification.
These
findings
improve
our
understanding
PFOA's
detrimental
demonstrating
protective
role
against
PFOA-induced
developmental
Язык: Английский
Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis
Environment & Health,
Год журнала:
2024,
Номер
3(4), С. 363 - 372
Опубликована: Дек. 11, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS)
are
persistent
environmental
pollutants
known
for
their
bioaccumulative
nature.
Reduced
bone
mineral
density
(BMD)
is
associated
with
an
increased
risk
of
developing
osteoporosis.
This
pioneering
study
aims
to
assess
the
effects
different
PFAS
compounds
on
mineral.
We
conducted
searches
online
databases.
Inclusion
criteria
included
presence
associations
between
perfluorooctanoic
acid
(PFOA),
perfluorooctanesulfonate
(PFOS),
perfluorohexanesulfonic
(PFHxS),
perfluorononanoic
(PFNA),
perfluorodecanoic
(PFDA)
BMD,
BMD
z-score,
content
(BMC).
Meta-analyses
were
performed.
Best
evidence
synthesis
(BES)
was
performed
summarize
results.
The
results
BES
showed
that
PFOS,
PFOA
PFNA
reduced
moderate.
variability
in
methods
assessing
sex
differences
potential
sources
heterogeneity
Meta
analysis
(β
−0.01,
95%
CI
−0.01
−0.00;
I2
=
0%).
Subgroup
by
PFOS
50%),
+0.00;
29%)
negatively
correlated
BMD.
systematic
review
revealed
negative
correlations
exposure
PFOA,
Sex
emerged
as
a
factor
affecting
damage
still
requires
further
exploration.
Язык: Английский