Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis DOI Creative Commons
Kai Tao, Bin Zeng,

Linghui Deng

et al.

Environment & Health, Journal Year: 2024, Volume and Issue: 3(4), P. 363 - 372

Published: Dec. 11, 2024

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their bioaccumulative nature. Reduced bone mineral density (BMD) is associated with an increased risk of developing osteoporosis. This pioneering study aims to assess the effects different PFAS compounds on mineral. We conducted searches online databases. Inclusion criteria included presence associations between perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonic (PFHxS), perfluorononanoic (PFNA), perfluorodecanoic (PFDA) BMD, BMD z-score, content (BMC). Meta-analyses were performed. Best evidence synthesis (BES) was performed summarize results. The results BES showed that PFOS, PFOA PFNA reduced moderate. variability in methods assessing sex differences potential sources heterogeneity Meta analysis (β −0.01, 95% CI −0.01 −0.00; I2 = 0%). Subgroup by PFOS 50%), +0.00; 29%) negatively correlated BMD. systematic review revealed negative correlations exposure PFOA, Sex emerged as a factor affecting damage still requires further exploration.

Language: Английский

Perfluorooctanoic acid and its alternatives disrupt the osteogenesis and osteoclastogenesis balance: Evidence from the effects on cell differentiation process DOI
Sijia Yang, Mengyuan Chen, Di Yang

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 959, P. 178331 - 178331

Published: Jan. 1, 2025

Language: Английский

Citations

1
Chronic environmental exposure to polystyrene microplastics increases the risk of nonalcoholic fatty liver disease DOI
Yujie Shi,

Runyang Hong,

Zhencheng Fan

et al.

Toxicology, Journal Year: 2025, Volume and Issue: 511, P. 154067 - 154067

Published: Jan. 25, 2025

Language: Английский

Citations

1
Chronic exposure to polystyrene microplastics triggers osteoporosis by breaking the balance of osteoblast and osteoclast differentiation DOI
Chun Pan,

Runyang Hong,

Kehan Wang

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 510, P. 154017 - 154017

Published: Nov. 27, 2024

Language: Английский

Citations

5
Perfluorooctanoic acid and perfluorooctane sulfonate inhibit in vitro osteogenesis: possible role of connexin 43-mediated gap-junctional intercellular communication DOI
Sijia Yang, Mengyuan Chen, Di Yang

et al.

Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

0
PPARγ-SMAD6 axis-mediated inhibition of osteogenic differentiation is involved in BPS-induced osteoporosis DOI Creative Commons

Zhenkun Weng,

Xiu Chen, Jian Jiao

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109442 - 109442

Published: April 1, 2025

Bisphenol S (BPS) is extensively utilized in personal care products, foods, and paper raising growing concerns about its potential environmental hazards. However, few studies have reported the effects of BPS exposure on bone homeostasis. In this study, using data from National Health Nutrition Examination Survey, we found a negative correlation between urinary mineral density (BMD). To further investigate underlying mechanisms, C57BL/6 mice were exposed to human-equivalent dose for 6 months. Micro-CT analysis demonstrated reduced femoral BMD mice, indicating that osteoporosis was caused by chronic exposure. RNA-seq showed activated PPARγ human primary mesenchymal stem cells (MSCs). Additionally, 3D molecular docking confirmed direct interaction PPARγ. Bioinformatics identified SMAD6 as downstream target Mechanistically, BPS-PPARγ PPARγ, promoting transcription, which inhibited osteogenic differentiation MSCs. High-throughput virtual screening revealed olodanrigan effectively blocked interaction, vitro assays inhibition MSCs induced BPS. supplementation levels, thereby reversing BPS-induced osteoporosis. summary, study elucidates role PPARγ-SMAD6 axis mediating highlights promising therapeutic intervention, offering new insights into health risks posed targets treatment.

Language: Английский

Citations

0
Embryonic exposure to GenX causes reproductive toxicity by disrupting the formation of the blood-testis barrier in mouse offspring DOI

Zhencheng Fan,

Runyang Hong,

Shuhao Li

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154161 - 154161

Published: April 1, 2025

Language: Английский

Citations

0
Mitigation of PFOA-Induced Developmental Toxicity in Danio rerio by Bacillus subtilis var. natto: Focus on Growth and Ossification DOI Open Access
Christian Giommi, Marta Lombó,

Francesca Francioni

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4261 - 4261

Published: April 30, 2025

Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that resists biological degradation and accumulates in organisms. It disrupts zebrafish embryo development, affecting their heartbeat rate locomotion. Meanwhile, probiotics are known to enhance the development ossification of embryos. In this study, we examined toxic effects PFOA on growth bone formation potential probiotic Bacillus subtilis var. natto counteract its toxicity. Larvae were exposed 0, 50, or 100 mg/L from hatching 21 days post-fertilization (dpf), with without dietary supplementation (107 CFU/larva/day), they sampled at 7, 14, dpf. exposure reduced standard length dpf, while co-administration mitigated these effects. Craniofacial cartilage defects appeared larvae 50 7 14 impaired Probiotics counteracted abnormalities. also delayed ossification, correlating downregulation col10a1a, runx2b, cyp26b1, treatment restored normal ossification. These findings improve our understanding PFOA's detrimental demonstrating protective role against PFOA-induced developmental

Language: Английский

Citations

0
Chronic exposure to polystyrene microplastics induces renal fibrosis via ferroptosis DOI

Runyang Hong,

Yujie Shi,

Zhencheng Fan

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 509, P. 153996 - 153996

Published: Nov. 10, 2024

Language: Английский

Citations

3
Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis DOI Creative Commons
Kai Tao, Bin Zeng,

Linghui Deng

et al.

Environment & Health, Journal Year: 2024, Volume and Issue: 3(4), P. 363 - 372

Published: Dec. 11, 2024

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their bioaccumulative nature. Reduced bone mineral density (BMD) is associated with an increased risk of developing osteoporosis. This pioneering study aims to assess the effects different PFAS compounds on mineral. We conducted searches online databases. Inclusion criteria included presence associations between perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonic (PFHxS), perfluorononanoic (PFNA), perfluorodecanoic (PFDA) BMD, BMD z-score, content (BMC). Meta-analyses were performed. Best evidence synthesis (BES) was performed summarize results. The results BES showed that PFOS, PFOA PFNA reduced moderate. variability in methods assessing sex differences potential sources heterogeneity Meta analysis (β −0.01, 95% CI −0.01 −0.00; I2 = 0%). Subgroup by PFOS 50%), +0.00; 29%) negatively correlated BMD. systematic review revealed negative correlations exposure PFOA, Sex emerged as a factor affecting damage still requires further exploration.

Language: Английский

Citations

0