Genome
editing,
also
known
as
gene
encompasses
a
broad
range
of
techniques
that
allows
targeted
changes
in
the
DNA
animals
(and
plants).
The
Genetic
Technology
(Precision
Breeding)
Bill
2022
-2023,
due
for
Second
Reading
House
Lords
on
21
November
2022,
intends
to
change
regulatory
definition
certain
genome-edited
animals.
Annual Review of Genetics,
Год журнала:
2023,
Номер
57(1), С. 361 - 390
Опубликована: Сен. 19, 2023
Genetic
biocontrol
aims
to
suppress
or
modify
populations
of
species
protect
public
health,
agriculture,
and
biodiversity.
Advancements
in
genome
engineering
technologies
have
fueled
a
surge
research
this
field,
with
one
gene
editing
technology,
CRISPR,
leading
the
charge.
This
review
focuses
on
current
state
CRISPR
for
genetic
pests
highlights
progress
ongoing
challenges
using
these
approaches.
Frontiers in Tropical Diseases,
Год журнала:
2022,
Номер
3
Опубликована: Окт. 14, 2022
Genetic-based
technologies
are
emerging
as
promising
tools
to
support
vector
population
control.
Vectors
of
human
malaria
and
dengue
have
been
the
main
focus
these
development
efforts,
but
in
recent
years
become
more
flexible
adaptable
may
therefore
wide-ranging
applications.
Culex
quinquefasciatus
,
for
example,
is
primary
avian
Hawaii
other
tropical
islands.
Avian
has
led
extinction
numerous
native
bird
species
many
continue
be
threatened
climate
change
expanding
range
this
mosquito.
would
ideal
control
they
offer
alternatives
interventions
that
difficult
implement
natural
areas,
such
larval
source
reduction,
limit
need
chemical
insecticides,
which
can
harm
beneficial
areas.
This
mosquito
also
an
important
diseases,
West
Nile
Saint
Louis
encephalitis
viruses,
so
genetic-based
efforts
could
a
direct
impact
on
health.
commentary
will
discuss
current
state
future
needs
lesser
studied,
disease
vectors,
C.
make
comparisons
available
studied
vectors.
While
most
genetic
focuses
disease,
we
address
both
conservation
focused
what
needed
prepare
evaluation
field.
The
versatility
result
variety
vectors
human,
animal,
ecosystem
Communications Biology,
Год журнала:
2024,
Номер
7(1)
Опубликована: Фев. 22, 2024
Māori
perspectives
on
gene
technologies
are
evolving,
and
traditional
cultural
constructs
continue
to
inform
a
wide
diversity
of
views.
Here
we
summarise
series
research
activities
aimed
at
identifying
evolving
editing
how
these
engagement
the
co-innovation
interface.
A
comment
article
summarizing
range
that
contribute
understanding
Gene
Editing
they
might
future
regulation.
Abstract
Background
Invasive
management
strategies
range
from
preventing
new
invasive
species
incursions
to
eliminating
established
populations,
with
all
requiring
effective
monitoring
guide
action.
The
use
of
DNA
sampled
the
environment
(eDNA)
is
one
such
tool
that
provides
ability
surveille
and
monitor
target
through
passive
sampling.
Technology
being
developed
eliminate
includes
genetic
biocontrol
in
form
gene
drive.
This
approach
would
drive
a
trait
population
could
be
used
or
modify
population.
Once
organism
released
into
then
changes
density
spread
critical.
Results
In
this
paper,
we
Mus
musculus
as
model
for
development
an
eDNA
assay
detects
wild-type
M.
.
We
demonstrate
successful
where
environmental
samples
detect
relative
Conclusions
method
both
(
t
CRISPR
)
expands
utility
DNA.
can
immediately
deployed
wild
across
world.
proof-of-concept
construct
monitored
using
samples.
Ecological Applications,
Год журнала:
2023,
Номер
33(7)
Опубликована: Авг. 24, 2023
Gene
drives
offer
a
potentially
revolutionary
method
for
pest
control
over
large
spatial
extents.
These
genetic
modifications
spread
deleterious
variants
through
population
and
have
been
proposed
as
methods
suppression
or
even
eradication.
We
examined
the
influence
of
local
dispersal,
long-distance
and/or
human-mediated
variation
in
growth
on
success
gene
drive
invasive
social
wasps
(Vespula
vulgaris).
Our
simulations
incorporated
spatially
realistic
environment
containing
variable
habitat
quality
New
Zealand.
Pest
eradication
was
not
observed,
except
extreme
unrealistic
scenarios
constant,
widespread,
intense
releases
genetically
modified
individuals
every
year
decades.
Instead,
regional
persistence
wild-type
predicted.
Simulations
using
homogeneous
versus
landscapes
(incorporating
uninhabitable
areas
dispersal
barriers)
showed
little
difference
overall
dynamics.
Overall,
impact
wasp
abundance
observed
first
15
years
after
introduction.
After
25
years,
populations
were
suppressed
to
levels
<95%
starting
populations.
Populations
exhibited
"chase
dynamics"
with
cycles
space,
extinction
occurring
some
while
became
abundant
others.
Increasing
wasps'
distance
increased
temporal
variability
occupied
area
suppression.
Varying
human-associated
had
effect
intrinsic
rates
interacted
cause
higher
mean
substantially
total
amount
landscape
occupied.
appear
unlikely
rapid
widespread
this
probably
other
pests
but
could
long-term
cost-effective
The
predicted
level
would
reduce
predation
pressure
competitive
interactions
native
species.
However,
will
ethics
likelihood
control,
especially
given
concerns
that
eventually
be
transported
back
their
home
range.
Abstract
Gene
drives
are
potentially
ontologically
and
morally
disruptive
technologies.
The
potential
to
shape
evolutionary
processes
eradicate
(e.g.
malaria-transmitting
or
invasive)
populations
raises
ontological
questions
about
evolution,
nature,
wilderness.
transformative
promises
perils
of
gene
also
raise
pressing
ethical
political
concerns.
aim
this
article
is
arrive
at
a
better
understanding
the
drive
debate
by
analysing
how
moral
assumptions
coproduced
in
debate.
Combining
philosophical
analysis
with
critical
reading
literature
an
ethnographic
study
two
leading
research
groups,
explores
hypothesis
that
development
characterized
particular
intervention-oriented
mode
coproduction.
Based
on
results
exploration,
we
highlight
need
for
broadening
perspective
which
empirical,
moral,
concerns
addressed
explicitly
their
interplay
rather
than
(disciplinary)
isolation
from
each
other.
GAIA - Ecological Perspectives for Science and Society,
Год журнала:
2023,
Номер
33(1), С. 170 - 174
Опубликована: Май 1, 2023
What
concepts
of
nature,
humans,
and
their
relationships
underpin
the
debate
about
gene
drives
for
conservation?
To
provide
some
answers
to
this
question,
eradication
invasive
rodents
on
islands
is
used
as
an
example.
While
current
debates
mostly
weigh
potential
benefits
conservation
against
ecological
risks,
it
worthwhile
move
beyond
such
a
risk-benefit
perspective.
Ethical
issues
that
are
more
specific
are:
significance
“natural”,
normative
goals
conservation,
ideal
living
in
harmony
with
nature.
Gates Open Research,
Год журнала:
2024,
Номер
8, С. 14 - 14
Опубликована: Фев. 22, 2024
Gene
drive
technology
has
been
recognized
for
its
potential
to
provide
durable
and
cost-effective
solutions
previously
intractable
problems
in
public
health,
conservation,
agriculture.
In
recognition
of
the
rapid
advances
this
field,
2016
U.S.
National
Academies
Sciences,
Engineering,
Medicine
issued
a
report
making
several
recommendations
aimed
at
researchers,
funders,
policymakers
safe
responsible
research
development
gene
technology.
Subsequently,
2017
sixteen
global
organizations
self-identifying
as
sponsors
supporters
became
signatories
committed
‘Principles
Gene
Drive
Research’
which
were
inspired
by
report’s
recommendations.
Herein
we
reflect
on
progress
relation
ethical
principles
laid
out
Principles.
Our
analysis
indicates
high
levels
alignment
with
Principles
field
research.
The
manuscript
also
discusses
Research
Forum,
had
genesis
publication
Discussions
between
participants
latest
meeting
Forum
point
work
that
lies
ahead
line
Going
forward
community
can
productively
focus
on:
i)
safety
efficacy
criteria
open
release,
ii)
risk
assessment
frameworks
methods,
iii)
more
downstream
technical,
regulatory
policy
considerations
evaluations
implementation,
iv)
continued
transparency
developing
mechanisms
accountability,
v)
strengthening
capacity
locales
release
expected
spread.