Genome edited animals DOI Open Access
Jonathan Wentworth,

David Rapley

Опубликована: Ноя. 17, 2022

Genome editing, also known as gene encompasses a broad range of techniques that allows targeted changes in the DNA animals (and plants). The Genetic Technology (Precision Breeding) Bill 2022 -2023, due for Second Reading House Lords on 21 November 2022, intends to change regulatory definition certain genome-edited animals.

Язык: Английский

Manipulating the Destiny of Wild Populations Using CRISPR DOI Creative Commons
Robyn Raban, John M. Marshall, Bruce A. Hay

и другие.

Annual Review of Genetics, Год журнала: 2023, Номер 57(1), С. 361 - 390

Опубликована: Сен. 19, 2023

Genetic biocontrol aims to suppress or modify populations of species protect public health, agriculture, and biodiversity. Advancements in genome engineering technologies have fueled a surge research this field, with one gene editing technology, CRISPR, leading the charge. This review focuses on current state CRISPR for genetic pests highlights progress ongoing challenges using these approaches.

Язык: Английский

Процитировано

11

Harnessing Synthetic Biology for Sustainable Industrial Innovation: Advances, Challenges, and Future Direction DOI
Emmanuel Chimeh Ezeako, Barine Innocent Nwiloh,

Malachy Chigozie Odo

и другие.

Biochemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 109777 - 109777

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Possibilities for a critical social science of assisted ecosystem adaptation and other climate intervention practices DOI Creative Commons
Stewart Lockie, Gillian Paxton

Environmental Sociology, Год журнала: 2025, Номер unknown, С. 1 - 9

Опубликована: Июнь 3, 2025

Язык: Английский

Процитировано

0

A perspective on the expansion of the genetic technologies to support the control of neglected vector-borne diseases and conservation DOI Creative Commons
Robyn Raban, William A.C. Gendron, Omar S. Akbari

и другие.

Frontiers in Tropical Diseases, Год журнала: 2022, Номер 3

Опубликована: Окт. 14, 2022

Genetic-based technologies are emerging as promising tools to support vector population control. Vectors of human malaria and dengue have been the main focus these development efforts, but in recent years become more flexible adaptable may therefore wide-ranging applications. Culex quinquefasciatus , for example, is primary avian Hawaii other tropical islands. Avian has led extinction numerous native bird species many continue be threatened climate change expanding range this mosquito. would ideal control they offer alternatives interventions that difficult implement natural areas, such larval source reduction, limit need chemical insecticides, which can harm beneficial areas. This mosquito also an important diseases, West Nile Saint Louis encephalitis viruses, so genetic-based efforts could a direct impact on health. commentary will discuss current state future needs lesser studied, disease vectors, C. make comparisons available studied vectors. While most genetic focuses disease, we address both conservation focused what needed prepare evaluation field. The versatility result variety vectors human, animal, ecosystem

Язык: Английский

Процитировано

7

Identifying Māori perspectives on gene editing in Aotearoa New Zealand DOI Creative Commons

Amanda Clark,

Phillip Wilcox,

Sandy Morrison

и другие.

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Фев. 22, 2024

Māori perspectives on gene technologies are evolving, and traditional cultural constructs continue to inform a wide diversity of views. Here we summarise series research activities aimed at identifying evolving editing how these engagement the co-innovation interface. A comment article summarizing range that contribute understanding Gene Editing they might future regulation.

Язык: Английский

Процитировано

1

Building an eDNA surveillance toolkit for invasive rodents on islands: can we detect wild-type and gene drive Mus musculus? DOI Creative Commons
Antoinette J. Piaggio, Luke Gierus,

Daniel R. Taylor

и другие.

BMC Biology, Год журнала: 2024, Номер 22(1)

Опубликована: Ноя. 15, 2024

Abstract Background Invasive management strategies range from preventing new invasive species incursions to eliminating established populations, with all requiring effective monitoring guide action. The use of DNA sampled the environment (eDNA) is one such tool that provides ability surveille and monitor target through passive sampling. Technology being developed eliminate includes genetic biocontrol in form gene drive. This approach would drive a trait population could be used or modify population. Once organism released into then changes density spread critical. Results In this paper, we Mus musculus as model for development an eDNA assay detects wild-type M. . We demonstrate successful where environmental samples detect relative Conclusions method both ( t CRISPR ) expands utility DNA. can immediately deployed wild across world. proof-of-concept construct monitored using samples.

Язык: Английский

Процитировано

1

Gene drives for invasive wasp control: Extinction is unlikely, with suppression dependent on dispersal and growth rates DOI Creative Commons
Philip J. Lester, David O’Sullivan, George L. W. Perry

и другие.

Ecological Applications, Год журнала: 2023, Номер 33(7)

Опубликована: Авг. 24, 2023

Gene drives offer a potentially revolutionary method for pest control over large spatial extents. These genetic modifications spread deleterious variants through population and have been proposed as methods suppression or even eradication. We examined the influence of local dispersal, long-distance and/or human-mediated variation in growth on success gene drive invasive social wasps (Vespula vulgaris). Our simulations incorporated spatially realistic environment containing variable habitat quality New Zealand. Pest eradication was not observed, except extreme unrealistic scenarios constant, widespread, intense releases genetically modified individuals every year decades. Instead, regional persistence wild-type predicted. Simulations using homogeneous versus landscapes (incorporating uninhabitable areas dispersal barriers) showed little difference overall dynamics. Overall, impact wasp abundance observed first 15 years after introduction. After 25 years, populations were suppressed to levels <95% starting populations. Populations exhibited "chase dynamics" with cycles space, extinction occurring some while became abundant others. Increasing wasps' distance increased temporal variability occupied area suppression. Varying human-associated had effect intrinsic rates interacted cause higher mean substantially total amount landscape occupied. appear unlikely rapid widespread this probably other pests but could long-term cost-effective The predicted level would reduce predation pressure competitive interactions native species. However, will ethics likelihood control, especially given concerns that eventually be transported back their home range.

Язык: Английский

Процитировано

3

Gene Drives as Interventions into Nature: the Coproduction of Ontology and Morality in the Gene Drive Debate DOI Creative Commons
Keje Boersma, Bernice Bovenkerk, David Ludwig

и другие.

NanoEthics, Год журнала: 2023, Номер 17(1)

Опубликована: Апрель 1, 2023

Abstract Gene drives are potentially ontologically and morally disruptive technologies. The potential to shape evolutionary processes eradicate (e.g. malaria-transmitting or invasive) populations raises ontological questions about evolution, nature, wilderness. transformative promises perils of gene also raise pressing ethical political concerns. aim this article is arrive at a better understanding the drive debate by analysing how moral assumptions coproduced in debate. Combining philosophical analysis with critical reading literature an ethnographic study two leading research groups, explores hypothesis that development characterized particular intervention-oriented mode coproduction. Based on results exploration, we highlight need for broadening perspective which empirical, moral, concerns addressed explicitly their interplay rather than (disciplinary) isolation from each other.

Язык: Английский

Процитировано

2

Novel organisms and the ethics of conservation: Divergent views on gene drives reflect divergent ideas about humans and nature DOI
Uta Eser

GAIA - Ecological Perspectives for Science and Society, Год журнала: 2023, Номер 33(1), С. 170 - 174

Опубликована: Май 1, 2023

What concepts of nature, humans, and their relationships underpin the debate about gene drives for conservation? To provide some answers to this question, eradication invasive rodents on islands is used as an example. While current debates mostly weigh potential benefits conservation against ecological risks, it worthwhile move beyond such a risk-benefit perspective. Ethical issues that are more specific are: significance “natural”, normative goals conservation, ideal living in harmony with nature.

Язык: Английский

Процитировано

2

Taking stock: Is gene drive research delivering on its principles? DOI Creative Commons
Aaron J. Roberts, Kristy Hackett,

Isabelle Coche

и другие.

Gates Open Research, Год журнала: 2024, Номер 8, С. 14 - 14

Опубликована: Фев. 22, 2024

Gene drive technology has been recognized for its potential to provide durable and cost-effective solutions previously intractable problems in public health, conservation, agriculture. In recognition of the rapid advances this field, 2016 U.S. National Academies Sciences, Engineering, Medicine issued a report making several recommendations aimed at researchers, funders, policymakers safe responsible research development gene technology. Subsequently, 2017 sixteen global organizations self-identifying as sponsors supporters became signatories committed ‘Principles Gene Drive Research’ which were inspired by report’s recommendations. Herein we reflect on progress relation ethical principles laid out Principles. Our analysis indicates high levels alignment with Principles field research. The manuscript also discusses Research Forum, had genesis publication Discussions between participants latest meeting Forum point work that lies ahead line Going forward community can productively focus on: i) safety efficacy criteria open release, ii) risk assessment frameworks methods, iii) more downstream technical, regulatory policy considerations evaluations implementation, iv) continued transparency developing mechanisms accountability, v) strengthening capacity locales release expected spread.

Язык: Английский

Процитировано

0