Plastic
pollution
continues
to
erupt
as
a
global
ecological
concern.
As
plastic
debris
is
degraded
into
nanoscale
and
microscale
particles
via
biodegradation,
UV-irradiation,
mechanical
processes,
nanoplastic
arises
threat
virtually
every
biological
system
on
the
planet.
In
this
study,
zebrafish
(Danio
rerio)
embryos
were
exposed
fluorescently
labeled
at
nanoscales
(30
nm
100
nm).
The
uptake
of
both
(NPs)
was
found
exponentially
increase
with
incubation
time.
Penetration
NPs
through
natural
barrier
embryos,
chorion,
observed
prior
hatching
embryo.
result,
accumulate
body
surface
well
inside
zebrafish.
invasion
induced
upregulation
several
stress
immune
response
genes
including
interleukins
(il6
il1b),
cytochrome
P450
(cyp1a
cyp51),
reactive
oxygen
species
(ROS)
removal
protein-encoding
(sod
cat).
This
suggested
initiation
ROS
generation
activation
embryos.
Colocalization
macrophages
in
indicated
involvement
macrophage
NP
early
developmental
stage
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
273, С. 116126 - 116126
Опубликована: Фев. 21, 2024
Nanopolystyrene
(NP)
and
phoxim
(PHO)
are
common
environmental
pollutants
in
aquatic
systems.
We
evaluated
the
toxic
effects
of
exposure
to
ambient
concentrations
NP
and/or
PHO
intestines
Chinese
mitten
crab
(Eriocheir
sinensis).
Our
study
showed
that
histopathological
changes
were
observed
intestines.
Specifically,
increased
intraepithelial
lymphocytes.
Furthermore,
induced
oxidative
stress,
as
evidenced
by
a
significant
decrease
superoxide
dismutase
activity
(SOD),
peroxidase
(POD),
total
antioxidant
capacity
(T-AOC).
Pro-inflammatory
gene
expression
transcriptome
analysis
demonstrated
intestinal
inflammatory
response.
Transcriptome
results
upregulated
NF-κB
signaling
pathway,
which
is
considered
key
pathway
Additionally,
pro-inflammatory
genes
significantly
after
single
or
PHO,
but
it
exhibited
co-exposure.
The
downregulation
these
co-exposure
group
likely
suggested
mitigated
inflammation
response
E.
sinensis.
Collectively,
our
findings
mainly
at
induces
stress
Birth Defects Research,
Год журнала:
2024,
Номер
116(6)
Опубликована: Июнь 1, 2024
Nanoplastics
can
be
considered
a
novel
contaminant
for
the
environment
because
of
their
extensive
applications
in
modern
society,
which
represents
possible
threat
to
humans.
Nevertheless,
negative
effect
polystyrene
nanoplastics
(PS-NPs)
on
male
reproduction,
fertility,
and
progeny
outcomes
is
not
well
known.
Thus,
aim
present
work
was
calculate
median
lethal
dose
(LD50)
investigate
consequences
exposure
PS-NPs
(25
nm)
reproductive
toxicity.
