Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia

Schizophrenia Bulletin, Год журнала: 2023, Номер 50(1), С. 199 - 209

Опубликована: Авг. 4, 2023

Low-grade neural and peripheral inflammation are among the proposed pathophysiological mechanisms of schizophrenia. White matter impairment is one more consistent findings in schizophrenia but underlying mechanism remains obscure. Many cerebral white components sensitive to neuroinflammatory conditions that can result demyelination, altered oligodendrocyte differentiation, other changes. We tested hypothesis immune-inflammatory response system (IRS) compensatory immune-regulatory reflex (IRS/CIRS) dynamics associated with reduced integrity patients

Язык: Английский

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Network structure of psychotic symptoms and childhood trauma in first-episode versus treatment-resistant schizophrenia

Journal of Psychiatric Research, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Role of peripheral cytokines and orbitofrontal cortex subregion structure in schizophrenia agitation

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 23, 2025

Язык: Английский

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Role of the immune-kynurenine pathway in treatment-resistant schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2023, Номер 130, С. 110926 - 110926

Опубликована: Дек. 24, 2023

Язык: Английский

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Comprehensive immunoprofiling of neurodevelopmental disorders suggests three distinct classes based on increased neurogenesis, Th-1 polarization or IL-1 signaling

Brain Behavior and Immunity, Год журнала: 2023, Номер 115, С. 505 - 516

Опубликована: Ноя. 14, 2023

Язык: Английский

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The association between inflammation and kynurenine pathway metabolites in electroconvulsive therapy for schizophrenia: Implications for clinical efficacy

Brain Behavior and Immunity, Год журнала: 2023, Номер 113, С. 1 - 11

Опубликована: Июнь 21, 2023

Язык: Английский

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Biomarkers of treatment-resistant schizophrenia: A systematic review

Neuroscience Applied, Год журнала: 2024, Номер 3, С. 104059 - 104059

Опубликована: Янв. 1, 2024

Treatment-resistant schizophrenia (TRS) is associated with great disability, functional impairment, and substantial socioeconomic costs. While clozapine indicated in patients TRS, its use restricted to who have not responded at least 2 other antipsychotics, thus implying a series of empirical trials different drugs before receiving effective treatment. In this scenario, the identification reliable biological markers predict risk for TRS starting pharmacological treatments might significantly improve management early stages. We conducted systematic review on PubMed, Scopus Web Science identify studies investigating peripheral TRS. A total 75 articles were included. These mostly investigated association between genetic (n = 42, which 16 genome-wide 25 candidate-gene design) protein/metabolite 23), while only minority RNA 5), methylation levels 4), gut microbiota profiles 1), or more than one type marker 3). The elucidation biomarkers challenging due large heterogeneity across terms clinical definition relatively small sample size many studies, as well lack powered integrating data multi-omic level. Nonetheless, available suggest be trait significant heritability point inflammation cytokine imbalance most promising pathways involved complex phenotype.

Язык: Английский

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Male-Biased Vulnerability of Mouse Brain Tryptophan/Kynurenine and Glutamate Systems to Adolescent Exposures to Concentrated Ambient Ultrafine Particle Air Pollution

NeuroToxicology, Год журнала: 2024, Номер 104, С. 20 - 35

Опубликована: Июль 11, 2024

Язык: Английский

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Changes in IL-6, IL-12, IL-5, IL-10 and TGF-β1 Concentration in Patients with Treatment-Resistant Schizophrenia (TRS) Following Electroconvulsive Therapy (ECT)—A Pilot Study

Biomedicines, Год журнала: 2024, Номер 12(11), С. 2637 - 2637

Опубликована: Ноя. 19, 2024

Treatment-resistant schizophrenia (TRS) may be considered as a neuro-immune disorder. Electroconvulsive therapy (ECT) remains an important therapeutic option for patients with TRS, however, its impact on cytokine profile is barely investigated. Therefore, this study attempts to establish associations between serum cytokines IL-6, IL-12, IL-5, IL-10 and TGF-β1 changes (pre- post-ECT) the effectiveness of ECT in TRS patients. The second aim search correlations concentrations above specified psychometric assessments clinical symptoms.

Язык: Английский

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Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study

Schizophrenia, Год журнала: 2024, Номер 10(1)

Опубликована: Дек. 20, 2024

Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated peripheral inflammation. However, it unclear whether such an delineates a biologically defined subgroup of SSD. Moreover, remains elusive how ChP linked to brain regions inflammation A cross-sectional cohort 132 SSD 107 age-matched healthy controls (HC) underwent cerebral magnetic resonance imaging (MRI) clinical phenotyping investigate the regions. case-control comparison volumes was conducted, structural variance analyzed by employing variability ratio (VR). K-means clustering analysis used identify subgroups distinct patterns ventricular system, clusters were compared terms demographic, clinical, immunological measures. The relationship between regions, previously inflammation, investigated. We did not find significant HC but detected increased VR lateral ventricle volumes. Based on these we identified 3 differences cognitive measures possibly inflammatory markers. Larger volume higher hippocampus, putamen, thalamus HC. This study suggests variability, mean volume, SSD,

Язык: Английский

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