Immune-Inflammatory Response And Compensatory Immune-Regulatory Reflex Systems And White Matter Integrity in Schizophrenia

Schizophrenia Bulletin, Journal Year: 2023, Volume and Issue: 50(1), P. 199 - 209

Published: Aug. 4, 2023

Low-grade neural and peripheral inflammation are among the proposed pathophysiological mechanisms of schizophrenia. White matter impairment is one more consistent findings in schizophrenia but underlying mechanism remains obscure. Many cerebral white components sensitive to neuroinflammatory conditions that can result demyelination, altered oligodendrocyte differentiation, other changes. We tested hypothesis immune-inflammatory response system (IRS) compensatory immune-regulatory reflex (IRS/CIRS) dynamics associated with reduced integrity patients

Language: Английский

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Network structure of psychotic symptoms and childhood trauma in first-episode versus treatment-resistant schizophrenia

Journal of Psychiatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Role of peripheral cytokines and orbitofrontal cortex subregion structure in schizophrenia agitation

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 23, 2025

Language: Английский

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Role of the immune-kynurenine pathway in treatment-resistant schizophrenia

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2023, Volume and Issue: 130, P. 110926 - 110926

Published: Dec. 24, 2023

Language: Английский

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Comprehensive immunoprofiling of neurodevelopmental disorders suggests three distinct classes based on increased neurogenesis, Th-1 polarization or IL-1 signaling

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 115, P. 505 - 516

Published: Nov. 14, 2023

Language: Английский

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The association between inflammation and kynurenine pathway metabolites in electroconvulsive therapy for schizophrenia: Implications for clinical efficacy

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 113, P. 1 - 11

Published: June 21, 2023

Language: Английский

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Biomarkers of treatment-resistant schizophrenia: A systematic review

Neuroscience Applied, Journal Year: 2024, Volume and Issue: 3, P. 104059 - 104059

Published: Jan. 1, 2024

Treatment-resistant schizophrenia (TRS) is associated with great disability, functional impairment, and substantial socioeconomic costs. While clozapine indicated in patients TRS, its use restricted to who have not responded at least 2 other antipsychotics, thus implying a series of empirical trials different drugs before receiving effective treatment. In this scenario, the identification reliable biological markers predict risk for TRS starting pharmacological treatments might significantly improve management early stages. We conducted systematic review on PubMed, Scopus Web Science identify studies investigating peripheral TRS. A total 75 articles were included. These mostly investigated association between genetic (n = 42, which 16 genome-wide 25 candidate-gene design) protein/metabolite 23), while only minority RNA 5), methylation levels 4), gut microbiota profiles 1), or more than one type marker 3). The elucidation biomarkers challenging due large heterogeneity across terms clinical definition relatively small sample size many studies, as well lack powered integrating data multi-omic level. Nonetheless, available suggest be trait significant heritability point inflammation cytokine imbalance most promising pathways involved complex phenotype.

Language: Английский

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Male-Biased Vulnerability of Mouse Brain Tryptophan/Kynurenine and Glutamate Systems to Adolescent Exposures to Concentrated Ambient Ultrafine Particle Air Pollution

NeuroToxicology, Journal Year: 2024, Volume and Issue: 104, P. 20 - 35

Published: July 11, 2024

Language: Английский

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Changes in IL-6, IL-12, IL-5, IL-10 and TGF-β1 Concentration in Patients with Treatment-Resistant Schizophrenia (TRS) Following Electroconvulsive Therapy (ECT)—A Pilot Study

Biomedicines, Journal Year: 2024, Volume and Issue: 12(11), P. 2637 - 2637

Published: Nov. 19, 2024

Treatment-resistant schizophrenia (TRS) may be considered as a neuro-immune disorder. Electroconvulsive therapy (ECT) remains an important therapeutic option for patients with TRS, however, its impact on cytokine profile is barely investigated. Therefore, this study attempts to establish associations between serum cytokines IL-6, IL-12, IL-5, IL-10 and TGF-β1 changes (pre- post-ECT) the effectiveness of ECT in TRS patients. The second aim search correlations concentrations above specified psychometric assessments clinical symptoms.

Language: Английский

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Investigation of choroid plexus variability in schizophrenia-spectrum disorders—insights from a multimodal study

Schizophrenia, Journal Year: 2024, Volume and Issue: 10(1)

Published: Dec. 20, 2024

Previous studies have suggested that choroid plexus (ChP) enlargement occurs in individuals with schizophrenia-spectrum disorders (SSD) and is associated peripheral inflammation. However, it unclear whether such an delineates a biologically defined subgroup of SSD. Moreover, remains elusive how ChP linked to brain regions inflammation A cross-sectional cohort 132 SSD 107 age-matched healthy controls (HC) underwent cerebral magnetic resonance imaging (MRI) clinical phenotyping investigate the regions. case-control comparison volumes was conducted, structural variance analyzed by employing variability ratio (VR). K-means clustering analysis used identify subgroups distinct patterns ventricular system, clusters were compared terms demographic, clinical, immunological measures. The relationship between regions, previously inflammation, investigated. We did not find significant HC but detected increased VR lateral ventricle volumes. Based on these we identified 3 differences cognitive measures possibly inflammatory markers. Larger volume higher hippocampus, putamen, thalamus HC. This study suggests variability, mean volume, SSD,

Language: Английский

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