Efficacy and acceptability of lurasidone for bipolar depression: a systematic review and dose–response meta-analysis

BMJ Mental Health, Год журнала: 2024, Номер 27(1), С. e301165 - e301165

Опубликована: Ноя. 1, 2024

Question The optimal dose of lurasidone for bipolar depression is unclear. This study examined its dose–response relationship efficacy, acceptability, and metabolic/endocrine profiles. Study selection analysis Five databases grey literature published until 1 August 2024, were systematically reviewed. outcomes included efficacy (changes in depression, anxiety, clinical global impression, disability quality life), acceptability (dropout, manic switch, suicidality side effects) profiles body weight, glucose, lipid prolactin levels). Effect sizes calculated using a one-step meta-analysis, expressed as standardised mean differences (SMDs), risk ratios (RRs) (MDs) with 95% CIs. Findings randomised trials (2032 patients, treatment duration 6 weeks) indicated that the therapeutic (40–60 mg) improved (50 mg: SMD −0.60 (95% CI −0.30, –0.89)), anxiety −0.32 −0.21, –0.42)), impression −0.67 –1.03)) −0.38 −0.08, –0.69)). Side effects increased higher doses RR 1.15 1.05, 1.25); 100 1.18 1.02, 1.36)), but dropout, switch did not show dose–effect relationship. Weight at doses<60 mg (40 MD 0.38 0.16, 0.60) kg), while blood glucose levels rose doses>70 (100 3.16 0.76, 5.57) mg/dL). Prolactin both males 3.21 1.59, 4.84) ng/mL; 5.61 2.42, 8.81)) females 6.64 3.50, 9.78); 5.33 0.67, 10.00)). Conclusions A daily 40–60 reasonable choice treatment. Trial registration number INPLASY202430069.

Язык: Английский

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Facing Life in Old Age: Exploring Resilience in Older Adults with Bipolar Disorder

Опубликована: Июнь 4, 2024

Background: Older adults with bipolar disorder (OABD) are individuals aged 50 years and older (BD). People BD may have fewer coping strategies or resilience. A long course of the disease, such as in OABD, could impact development resilience strategies, but this remains under-researched OABD. Therefore, study aims to assess levels within OABD explore associated factors, hypothesizing that improve psychosocial functioning, wellbeing quality life patients. Methods: This sampled 33 patients from cohort at Bipolar Depressive Disorders Unit Hospital Clinic Barcelona. was an observational, descriptive cross-sectional study. Demographic clinical variables well cognitive reserve were analyzed. Resilience measured using CD-RISC-10. Non-parametric tests used for statistical analysis. Results: The average CD-RISC-10 score 25.67 points (SD 7.87). negatively correlated total number episodes (p = 0.034), depressive 0.001), FAST &lt; 0.001). Participants normal had a lower 0.046), higher CRASH 0.026), more EOBD 0.037) compared those low Conclusions: exhibit which correlate psychiatric episodes, particularly depressions worse functioning reserve. Better understanding characterization aid early identification requiring additional support foster enhance management.

Язык: Английский

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Facing Life in Old Age: Exploring Resilience in Older Adults with Bipolar Disorder

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(13), С. 3942 - 3942

Опубликована: Июль 5, 2024

Background: Older adults with bipolar disorder (OABD) are individuals aged 50 years and older (BD). People BD may have fewer coping strategies or resilience. A long duration of the disease, as seen in this population, could affect development resilience strategies, but remains under-researched. Therefore, study aims to assess levels within OABD population explore associated factors, hypothesizing that improve psychosocial functioning, wellbeing quality life these patients. Methods: This sampled 33 patients from cohort at Bipolar Depressive Disorders Unit Hospital Clinic Barcelona. It was an observational, descriptive cross-sectional study. Demographic clinical variables well cognitive reserve were analyzed. Resilience measured using CD-RISC-10. Non-parametric tests used for statistical analysis. Results: The average CD-RISC-10 score 25.67 points (SD 7.87). negatively correlated total number episodes (p = 0.034), depressive 0.001), FAST < 0.001). Participants normal had a lower functioning 0.046), higher 0.026), earlier onset 0.037) compared those low Conclusions: which correlate more psychiatric episodes, especially worse reserve. Better understanding characterization help early identification requiring additional support foster enhance management.

Язык: Английский

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Contrasting genetic burden for bipolar disorder: Early onset versus late onset in an older adult bipolar disorder sample

European Neuropsychopharmacology, Год журнала: 2024, Номер 92, С. 29 - 37

Опубликована: Дек. 22, 2024

Язык: Английский

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