Pharmaceuticals,
Год журнала:
2024,
Номер
17(9), С. 1169 - 1169
Опубликована: Сен. 4, 2024
Skin
inflammation
associated
with
chronic
diseases
involves
a
direct
role
of
keratinocytes
in
its
immunopathogenesis,
triggering
cascade
immune
responses.
Despite
this,
highly
targeted
treatments
remain
elusive,
highlighting
the
need
for
more
specific
therapeutic
strategies.
In
this
study,
nanocapsules
containing
quinizarin
(QZ/NC)
were
developed
and
evaluated
an
vitro
model
keratinocyte-mediated
inflammation,
incorporating
action
photodynamic
therapy
(PDT)
analyzing
permeation
3D
skin
model.
Comprehensive
physicochemical,
stability,
cytotoxicity,
analyses
nanomaterials
conducted.
The
demonstrated
desirable
physicochemical
properties,
remained
stable
throughout
analysis
period,
exhibited
no
spectroscopic
alterations.
Cytotoxicity
tests
revealed
toxicity
at
lowest
concentrations
QZ/NC.
Permeation
cellular
uptake
studies
confirmed
QZ/NC
models,
along
intracellular
incorporation
internalization
drug,
thereby
enhancing
efficacy
drug
delivery.
inducing
inflammatory
process
yielded
promising
results,
particularly
when
synthesized
nanomaterial
was
combined
PDT,
showing
reduction
cytokine
levels.
These
findings
suggest
potential
new
approach
treating
diseases.
Advanced Materials,
Год журнала:
2024,
Номер
36(24)
Опубликована: Март 6, 2024
Abstract
The
quest
for
effective
and
reliable
methods
of
delivering
medications,
with
the
aim
improving
delivery
therapeutic
agent
to
intended
location,
has
presented
a
demanding
yet
captivating
field
in
biomedical
research.
concept
smart
drug
systems
is
an
evolving
approach,
serving
as
model
directing
drugs
specific
targets
or
sites.
These
have
been
developed
specifically
target
regulate
administration
substances
diverse
array
chronic
conditions,
including
periodontitis,
diabetes,
cardiac
diseases,
inflammatory
bowel
rheumatoid
arthritis,
different
cancers.
Nevertheless,
numerous
comprehensive
clinical
trials
are
still
required
ascertain
both
immediate
enduring
impacts
such
nanosystems
on
human
subjects.
This
review
delves
into
benefits
vehicles,
aiming
enhance
comprehension
their
applicability
addressing
present
medical
requirements.
Additionally,
it
touches
upon
current
applications
these
stimuli‐reactive
biomedicine
outlines
future
development
prospects.
Medicine in Drug Discovery,
Год журнала:
2024,
Номер
22, С. 100183 - 100183
Опубликована: Март 8, 2024
Psoriasis
is
a
chronic
autoimmune
disorder
that
has
major
effect
on
the
quality
of
life
for
millions
people
throughout
world.
The
pathogenesis
psoriasis
revealed
intricate
molecular
networks
and
signaling
pathways,
opening
new
avenues
precision
medicine.
treatments
include
topical
therapy,
phototherapy,
systemic
therapies,
biologics,
but
achieving
optimal
outcomes
difficult.
Despite
advancements
in
understanding
causes
development
various
treatments,
optimizing
therapeutic
remains
challenging.
Managing
poses
challenges
terms
drug
delivery
evaluation
models.
Novel
systems
capable
navigating
complex
skin
barriers
delivering
therapeutics
precisely
to
target
cells
are
crucial
advancing
treatment
options.
This
article
provides
an
inclusive
overview
psoriasis,
highlighting
recent
discoveries
potential
targets.
emphasizes
importance
combining
different
modalities,
such
as
synthetic
herbal
agents,
with
biologics
improve
efficacy.
Nanocarriers
show
promise
targeted
they
can
encapsulate
antipsoriatic
drugs,
gene
providing
enhanced
stability,
improved
tissue
penetration,
precise
cellular
targeting.
These
have
revolutionize
by
maximizing
efficacy
while
minimizing
side
effects.
also
discusses
commercial
formulations,
including
patents
related
ongoing
clinical
trials,
which
provide
valuable
insights
into
evolving
landscape
therapeutics.
provided
contribute
field
offer
hope
patients
suffering
from
psoriasis.
RSC Medicinal Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Cur-CNEs/Gel
combines
the
superior
skin
penetration
efficiency
of
cell-penetrating
peptide
modified
curcumin-loaded
nanoemulsions
and
prolonged
retention
ability
oligopeptide
hydrogel.
Pharmaceutics,
Год журнала:
2025,
Номер
17(1), С. 56 - 56
Опубликована: Янв. 3, 2025
Psoriasis,
a
chronic
inflammatory
dermatosis,
represents
significant
clinical
challenge
due
to
its
complex
pathogenesis
and
the
limitations
of
existing
therapeutic
strategies.
Current
psoriasis
diagnoses
are
primarily
clinician-dependent,
with
instrumental
diagnostics
serving
as
adjuncts.
Ongoing
research
is
progressively
deciphering
molecular
underpinnings;
future
may
involve
genetic
immunological
profiling
pinpoint
biomarkers,
enabling
more
accurate
timely
interventions.
The
administration
medications,
whether
oral,
injectable,
or
topical,
associated
range
side
effects
compliance
issues.
Topical
despite
their
advantages
in
patient
reduced
systemic
effects,
hindered
by
altered
skin
barrier
psoriasis,
which
impedes
effective
drug
penetration
retention.
In
recent
years,
development
novel
transdermal
delivery
systems
promising
frontier
management.
Nanotechnology-,
microneedle-
dressing-based
have
demonstrated
potential
for
improved
penetration,
enhanced
bioavailability,
extended
retention
time.
Here,
we
will
focus
on
latest
insights
into
etiology,
diagnostic
methodologies,
approaches
particular
emphasis
evolution
challenges
systems.
Molecular Pharmaceutics,
Год журнала:
2024,
Номер
21(5), С. 2118 - 2147
Опубликована: Апрель 25, 2024
The
various
kinds
of
nanocarriers
(NCs)
have
been
explored
for
the
delivery
therapeutics
designed
management
skin
manifestations.
NCs
are
considered
as
one
promising
approaches
attributable
to
sustained
release
and
enhanced
penetration.
Despite
extensive
applications
NCs,
challenges
in
their
via
barrier
(majorly
stratum
corneum)
persisted.
To
overcome
all
associated
with
microneedle
(MN)
technology
has
emerged
a
beacon
hope.
Programmable
drug
release,
being
painless,
its
minimally
invasive
nature
make
it
an
intriguing
strategy
circumvent
multiple
systems.
integration
positive
traits
MNs
boosts
therapeutic
effectiveness
by
evading
corneum,
facilitating
through
enhancing
targeted
delivery.
This
review
discusses
function
skin,
importance
MNs,
types
superiority
NC-loaded
MNs.
We
highlighted
NC-integrated
ailments,
combinational
delivery,
active
targeting,
vivo
imaging,
theranostics.
clinical
trials,
patent
portfolio,
marketed
products
drug/NC-integrated
covered.
Finally,
regulatory
hurdles
toward
benchtop-to-bedside
translation,
along
prospects
needed
scale
up
MN
technology,
deliberated.
current
is
anticipated
deliver
thoughtful
visions
researchers,
clinicians,
formulation
scientists
successful
development
MN-technology-based
product
carefully
optimizing
variables.
