Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 104, С. 106466 - 106466
Опубликована: Ноя. 30, 2024
Язык: Английский
Journal of Drug Delivery Science and Technology, Год журнала: 2024, Номер 104, С. 106466 - 106466
Опубликована: Ноя. 30, 2024
Язык: Английский
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 264, С. 130741 - 130741
Опубликована: Март 7, 2024
Язык: Английский
Процитировано
28International Journal of Biological Macromolecules, Год журнала: 2024, Номер 262, С. 129940 - 129940
Опубликована: Фев. 5, 2024
Язык: Английский
Процитировано
19Molecules, Год журнала: 2025, Номер 30(2), С. 207 - 207
Опубликована: Янв. 7, 2025
The scientific interest in the chemical modification of chitosan to increase its solubility and application has led conjugation with Schiff bases, which are interesting scaffolds endowed diverse biological properties. resultant chitosan-based bases (CSBs) widely studied literature due myriad activities exerted, both catalytic biological, including anticancer, anti-inflammatory, antioxidant, especially antimicrobial ones. Antimicrobial resistance (AMR) is one major public health challenges twenty-first century because it represents a threat prevention treatment growing number bacterial, parasitic, viral, fungal infections that no longer treatable available drugs. Thus, this review, we present brief outline CSBs as well their complexes metals, particular focus on recent regarding effect these captivating derivatives.
Язык: Английский
Процитировано
4Carbohydrate Polymers, Год журнала: 2024, Номер 344, С. 122503 - 122503
Опубликована: Июль 19, 2024
Язык: Английский
Процитировано
11Biomaterials Advances, Год журнала: 2024, Номер 164, С. 213983 - 213983
Опубликована: Авг. 3, 2024
Язык: Английский
Процитировано
9International Journal of Biological Macromolecules, Год журнала: 2024, Номер 281, С. 136514 - 136514
Опубликована: Окт. 14, 2024
Язык: Английский
Процитировано
7Biomaterials Science, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Cu-BTC mofs embedded, tannic acid loaded 3-D polymeric hydrogel composed of gellan gum, zein for deep wound healing.
Язык: Английский
Процитировано
1Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Ноя. 6, 2024
Within the clinical realm, complexities of wound healing have consistently presented formidable challenges. Recent advancements, notably in hydrogel technologies, broadened therapeutic spectrum. This study focuses on investigating a novel dual responsive composite for healing. is ingeniously designed to maintain an optimal moist environment, expedite healing, and combat bacterial infection during recovery. combining carboxymethyl chitosan (CMC), oxidized hyaluronic acid (OHA), sodium alginate (SA), addition, tobramycin (TOB) was incorporated create CMC/OHA/SA/TOB hydrogel. Hydrogel cross-linking verified by infrared spectroscopy, microstructure examined with scanning electron microscopy. We explored its swelling degradation behaviors different pH environments. The drug release profile biocompatibility evaluated via cytotoxicity hemolysis assays. antibacterial efficacy tested both solid liquid media. Additionally, models Sprague–Dawley (SD) rat employed investigate hydrogel's capabilities vivo. Results showed that CMCOHA/SA/TOB effectively cross-linked network structure. exhibited pronounced responsiveness characteristics, which significantly influenced levels pH. In vitro results demonstrated exhibits limited hemolysis, coupled characteristics. Antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli confirmed. Furthermore, vivo experiments underscored proficiency promoting highlighting potential applications. not only fosters environment essential enhances structural stability, but it also functional degradation. These distinctive abilities enable precise TOB, thereby optimizing
Язык: Английский
Процитировано
4Gels, Год журнала: 2025, Номер 11(3), С. 169 - 169
Опубликована: Фев. 26, 2025
In this study, self-healing hydrogels were created using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS), displaying antioxidant antibacterial properties for pH-responsive drug delivery. The structures of the modified polysaccharides confirmed through 1H NMR analysis. Double crosslinking in hydrogel occurred via imine bonds (between aldehyde group OHbG amine QCMCS) ionic interactions carboxyl QCMCS). exhibited improved thermal stability with an increase concentration. OHbG/QCMCS demonstrated high compressive strength, significant swelling, large pore size. Drug release profiles varied between pH 2.0 (96.57%) 7.4 (63.22%). Additionally, displayed effects without compromising polysaccharides’ inherent characteristics. No cytotoxicity was observed any samples. These findings indicate that is a biocompatible stimuli-responsive carrier, potential various pharmaceutical, biomedical, biotechnological applications.
Язык: Английский
Процитировано
0International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(4), С. 1961 - 1961
Опубликована: Фев. 6, 2024
Tissue engineering is an interdisciplinary field that develops new methods to enhance the regeneration of damaged tissues, including those wounds. Polymer systems containing bioactive molecules can play important role in accelerating tissue regeneration, mitigating inflammation process, and fighting bacterial infection. Chitosan (CS) has attracted much attention regarding its use wound healing system fabrication thanks biocompatibility, biodegradability, presence functional groups structure. In this work, chitosan-based membranes were obtained by both chemical physical modifications polymer with glycidyl methacrylate glycerol (GLY), respectively. The most suitable GLY concentration obtain good elongation at break, a water vapor transmission rate (WVTR), wettability values was 20% (w/w). Afterwards, crosslinked different concentrations ethylene glycol dimethacrylate (EGDMA). By using 0.05 mM EGDMA, contact angle WVTR for application obtained. To make bioactive, 3,4-dihydrocinnamic acid (HCAF) introduced into membranes, either imbibition or reaction, laccase as catalyst. Thermal mechanical analyses confirmed formation cohesive network, which limited plasticizing effect GLY, particularly when HCAF chemically bound. HCAF-imbibed membrane showed antioxidant antimicrobial activity, highlighting potential treatment healing.
Язык: Английский
Процитировано
2