A pH responsive tannic acid/quaternized carboxymethyl chitosan/oxidized sodium alginate hydrogels for accelerated diabetic wound healing and real-time monitoring

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130741 - 130741

Published: March 7, 2024

Language: Английский

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Advances in the construction and application of konjac glucomannan-based delivery systems

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 262, P. 129940 - 129940

Published: Feb. 5, 2024

Language: Английский

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Chitosan-Based Schiff Bases (CSBs) and Their Metal Complexes: Promising Antimicrobial Agents

Molecules, Journal Year: 2025, Volume and Issue: 30(2), P. 207 - 207

Published: Jan. 7, 2025

The scientific interest in the chemical modification of chitosan to increase its solubility and application has led conjugation with Schiff bases, which are interesting scaffolds endowed diverse biological properties. resultant chitosan-based bases (CSBs) widely studied literature due myriad activities exerted, both catalytic biological, including anticancer, anti-inflammatory, antioxidant, especially antimicrobial ones. Antimicrobial resistance (AMR) is one major public health challenges twenty-first century because it represents a threat prevention treatment growing number bacterial, parasitic, viral, fungal infections that no longer treatable available drugs. Thus, this review, we present brief outline CSBs as well their complexes metals, particular focus on recent regarding effect these captivating derivatives.

Language: Английский

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Konjac glucomannan-based composite materials: Construction, biomedical applications, and prospects

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 344, P. 122503 - 122503

Published: July 19, 2024

Language: Английский

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Copper-MOF and tannic acid-empowered composite cryogel as a skin substitute for accelerated deep wound healing

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 164, P. 213983 - 213983

Published: Aug. 3, 2024

Language: Английский

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Protocatechuic acid grafted chitosan/oxidized glucomannan hydrogel with antimicrobial and anti-inflammatory effects for enhancing wound repair

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136514 - 136514

Published: Oct. 14, 2024

Language: Английский

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Engineering a bacterial polysaccharide-based Metal-organic framework enhanced bioactive 3D hydrogel for accelerated full-thickness wound healing

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Cu-BTC mofs embedded, tannic acid loaded 3-D polymeric hydrogel composed of gellan gum, zein for deep wound healing.

Language: Английский

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A functional dual responsive CMC/OHA/SA/TOB hydrogel as wound dressing to enhance wound healing

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 6, 2024

Within the clinical realm, complexities of wound healing have consistently presented formidable challenges. Recent advancements, notably in hydrogel technologies, broadened therapeutic spectrum. This study focuses on investigating a novel dual responsive composite for healing. is ingeniously designed to maintain an optimal moist environment, expedite healing, and combat bacterial infection during recovery. combining carboxymethyl chitosan (CMC), oxidized hyaluronic acid (OHA), sodium alginate (SA), addition, tobramycin (TOB) was incorporated create CMC/OHA/SA/TOB hydrogel. Hydrogel cross-linking verified by infrared spectroscopy, microstructure examined with scanning electron microscopy. We explored its swelling degradation behaviors different pH environments. The drug release profile biocompatibility evaluated via cytotoxicity hemolysis assays. antibacterial efficacy tested both solid liquid media. Additionally, models Sprague–Dawley (SD) rat employed investigate hydrogel's capabilities vivo. Results showed that CMCOHA/SA/TOB effectively cross-linked network structure. exhibited pronounced responsiveness characteristics, which significantly influenced levels pH. In vitro results demonstrated exhibits limited hemolysis, coupled characteristics. Antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli confirmed. Furthermore, vivo experiments underscored proficiency promoting highlighting potential applications. not only fosters environment essential enhances structural stability, but it also functional degradation. These distinctive abilities enable precise TOB, thereby optimizing

Language: Английский

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Self-Healing Hydrogels with Intrinsic Antioxidant and Antibacterial Properties Based on Oxidized Hydroxybutanoyl Glycan and Quaternized Carboxymethyl Chitosan for pH-Responsive Drug Delivery

Gels, Journal Year: 2025, Volume and Issue: 11(3), P. 169 - 169

Published: Feb. 26, 2025

In this study, self-healing hydrogels were created using oxidized hydroxybutanoyl glycan (OHbG) and quaternized carboxymethyl chitosan (QCMCS), displaying antioxidant antibacterial properties for pH-responsive drug delivery. The structures of the modified polysaccharides confirmed through 1H NMR analysis. Double crosslinking in hydrogel occurred via imine bonds (between aldehyde group OHbG amine QCMCS) ionic interactions carboxyl QCMCS). exhibited improved thermal stability with an increase concentration. OHbG/QCMCS demonstrated high compressive strength, significant swelling, large pore size. Drug release profiles varied between pH 2.0 (96.57%) 7.4 (63.22%). Additionally, displayed effects without compromising polysaccharides’ inherent characteristics. No cytotoxicity was observed any samples. These findings indicate that is a biocompatible stimuli-responsive carrier, potential various pharmaceutical, biomedical, biotechnological applications.

Language: Английский

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Development of Antioxidant and Antimicrobial Membranes Based on Functionalized and Crosslinked Chitosan for Tissue Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(4), P. 1961 - 1961

Published: Feb. 6, 2024

Tissue engineering is an interdisciplinary field that develops new methods to enhance the regeneration of damaged tissues, including those wounds. Polymer systems containing bioactive molecules can play important role in accelerating tissue regeneration, mitigating inflammation process, and fighting bacterial infection. Chitosan (CS) has attracted much attention regarding its use wound healing system fabrication thanks biocompatibility, biodegradability, presence functional groups structure. In this work, chitosan-based membranes were obtained by both chemical physical modifications polymer with glycidyl methacrylate glycerol (GLY), respectively. The most suitable GLY concentration obtain good elongation at break, a water vapor transmission rate (WVTR), wettability values was 20% (w/w). Afterwards, crosslinked different concentrations ethylene glycol dimethacrylate (EGDMA). By using 0.05 mM EGDMA, contact angle WVTR for application obtained. To make bioactive, 3,4-dihydrocinnamic acid (HCAF) introduced into membranes, either imbibition or reaction, laccase as catalyst. Thermal mechanical analyses confirmed formation cohesive network, which limited plasticizing effect GLY, particularly when HCAF chemically bound. HCAF-imbibed membrane showed antioxidant antimicrobial activity, highlighting potential treatment healing.

Language: Английский

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