Corneal stromal repair and regeneration

Progress in Retinal and Eye Research, Год журнала: 2022, Номер 91, С. 101090 - 101090

Опубликована: Май 29, 2022

Язык: Английский

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The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates

Cell Death and Disease, Год журнала: 2022, Номер 13(5)

Опубликована: Май 31, 2022

Abstract Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein B, PKB) signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cycle, synthesis, glucose metabolism, and telomere activity. Corneal epithelial cells (CECs) are outermost of cornea; they maintain good optical performance act a physical immune barrier. Various growth factors, including epidermal factor receptor (EGFR) ligands, insulin-like 1 (IGF1), neurokinin (NK-1), insulin activate PI3K/AKT pathway by binding their receptors promote antiapoptotic, anti-inflammatory, proliferative, migratory functions wound healing in corneal epithelium (CE). Reactive oxygen species (ROS) regulate apoptosis inflammation CECs concentration-dependent manner. Extreme environments induce excess ROS accumulation, inhibit PI3K/AKT, cause CECs. However, at low or moderate levels, signalling, inhibiting stimulating proliferation healthy Diabetes-associated hyperglycaemia directly increasing endoplasmic reticulum (ER) stress levels suppressing expression factors diabetic keratopathy (DK) Similarly, hyperosmolarity accumulation suppress dry eye disease (DED). significant overactivation pathway, which mediates CECs, is observed both infectious noninfectious keratitis. Overall, upon activation NK-1, promotes migration, anti-apoptosis these processes can be regulated Moreover, inhibited from individuals with DK DED, but overactivated

Язык: Английский

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The impact of sensory neuropathy and inflammation on epithelial wound healing in diabetic corneas

Progress in Retinal and Eye Research, Год журнала: 2022, Номер 89, С. 101039 - 101039

Опубликована: Янв. 4, 2022

Язык: Английский

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Gene Therapy in the Anterior Eye Segment

Current Gene Therapy, Год журнала: 2021, Номер 22(2), С. 104 - 131

Опубликована: Апрель 27, 2021

: This review provides comprehensive information about the advances in gene therapy anterior segment of eye, including cornea, conjunctiva, lacrimal gland, and trabecular meshwork. We discuss delivery systems, viral non-viral vectors as well editing techniques, mainly CRISPR-Cas9, epigenetic treatments, antisense siRNA therapeutics. also provide a detailed analysis various diseases where has been tested with corresponding outcomes. Disease conditions include corneal conjunctival fibrosis scarring, epithelial wound healing, graft survival, neovascularization, genetic dystrophies, herpetic keratitis, glaucoma, dry eye disease, other ocular surface diseases. Although most analyzed results on use validity at have obtained vitro or using animal models, we available human studies. Gene approaches are currently considered very promising emerging future treatments diseases, this field is rapidly expanding.

Язык: Английский

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Understanding Ocular Findings and Manifestations of Systemic Lupus Erythematosus: Update Review of the Literature

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(20), С. 12264 - 12264

Опубликована: Окт. 14, 2022

Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease. Up to one-third of patients suffering from SLE have various ocular manifestations. The findings may represent the initial manifestation systemic disease and lead severe complications, even loss vision. Ocular manifestations are often associated with degree inflammation, but also can precede occurrence symptoms. Early diagnosis adequate management crucial require cooperation between specialists. Proper preparation ophthalmologists help differentiate complication other disorders. New therapies for promising potential benefits, however, side effects still unknown.

Язык: Английский

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Cell therapy in the cornea: The emerging role of microenvironment

Progress in Retinal and Eye Research, Год журнала: 2024, Номер 102, С. 101275 - 101275

Опубликована: Май 24, 2024

Язык: Английский

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Quality assurance in corneal transplants: Donor cornea assessment and oversight

Survey of Ophthalmology, Год журнала: 2024, Номер 69(3), С. 465 - 482

Опубликована: Янв. 8, 2024

Язык: Английский

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Congenital anterior segment ocular disorders: Genotype-phenotype correlations and emerging novel mechanisms

Progress in Retinal and Eye Research, Год журнала: 2024, Номер 102, С. 101288 - 101288

Опубликована: Авг. 2, 2024

Язык: Английский

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Clinical Management of Herpes Simplex Virus Keratitis

Diagnostics, Год журнала: 2022, Номер 12(10), С. 2368 - 2368

Опубликована: Сен. 29, 2022

Herpes simplex virus (HSV) keratitis is one of the leading causes blindness worldwide. Additionally, up to 90% population in some countries seropositive for HSV. HSV can cause a wide spectrum ocular disease ranging from blepharitis retinitis. Although initial clinical expressions HSV-1 and HSV-2 are similar, has been reported more frequently association with recurrent disease. Besides irreversible vision loss keratitis, also encephalitis genital forms Despite these statistics, there remains no vaccine against Current treatment therapies related diseases include use oral topical antivirals corticosteroids. While effective many cases, they fail address latency elimination virus, making it ineffective addressing recurrences, factor which increases risk loss. As such, need continued research other potential therapeutic targets. This review utilized several published articles regarding manifestations antiviral immune responses infection, management keratitis. will summarize current knowledge on host–virus interaction infections, as well highlighting therapeutics.

Язык: Английский

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Peroxisome proliferator-activated receptor-α (PPARα) regulates wound healing and mitochondrial metabolism in the cornea

Proceedings of the National Academy of Sciences, Год журнала: 2023, Номер 120(13)

Опубликована: Март 21, 2023

Diabetes can result in impaired corneal wound healing. Mitochondrial dysfunction plays an important role diabetic complications. However, the regulation of mitochondria function cornea and its impacts on healing remain elusive. The present study aimed to explore molecular basis for disturbed mitochondrial metabolism subsequent impairment cornea. Seahorse analysis showed that oxidative phosphorylation is a major source ATP production human epithelial cells. Live biopsy punches from type 1 2 mouse models functions, correlating with healing, compared nondiabetic controls. To approach function, we found Peroxisome Proliferator-Activated Receptor-α (PPARα) expression was downregulated corneas. Even without diabetes, global PPARα knockout mice epithelium-specific conditional delayed cornea, similar In contrast, fenofibrate, agonist, ameliorated enhanced corneas mice. Similarly, transgenic overexpression improved Furthermore, agonist primary cells exposed stressors, which impeded by siRNA knockdown , suggesting PPARα-dependent mechanism. These findings suggest downregulation epithelium diabetes.

Язык: Английский

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