Nano TransMed, Год журнала: 2024, Номер unknown, С. 100056 - 100056
Опубликована: Окт. 1, 2024
Язык: Английский
Progress in Retinal and Eye Research, Год журнала: 2022, Номер 91, С. 101090 - 101090
Опубликована: Май 29, 2022
Язык: Английский
Процитировано
120
Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)
Опубликована: Июль 22, 2023
Abstract Ocular drug delivery has constantly challenged ophthalmologists and scientists due to various anatomical physiological barriers. Static dynamic ocular barriers prevent the entry of exogenous substances impede therapeutic agents' active absorption. This review elaborates on anatomy eye associated constraints. Followed by an illustration some common diseases, including glaucoma their current clinical therapies, emphasizing significance therapy in treating diseases. Subsequently, advances modalities, especially nanotechnology-based systems, are recommended, typical research is highlighted. Based related research, systematic comprehensive characterizations nanocarriers summarized, hoping assist with future research. Besides, we summarize ophthalmic drugs currently market or still trials recent patents nanocarriers. Finally, inspired trends concepts, provide insight into challenges faced novel systems further put forward directions for We hope this can inspiration motivation better design development formulations. Graphical abstract
Язык: Английский
Процитировано
87
MedComm, Год журнала: 2023, Номер 4(3)
Опубликована: Июнь 1, 2023
Gene therapy, a medical approach that involves the correction or replacement of defective and abnormal genes, plays an essential role in treatment complex refractory diseases, such as hereditary cancer, rheumatic immune diseases. Nucleic acids alone do not easily enter target cells due to their easy degradation vivo structure cell membranes. The introduction genes into biological is often dependent on gene delivery vectors, adenoviral which are commonly used therapy. However, traditional viral vectors have strong immunogenicity while also presenting potential infection risk. Recently, biomaterials attracted attention for use efficient vehicles, because they can avoid drawbacks associated with vectors. Biomaterials improve stability nucleic efficiency intracellular delivery. This review focused biomaterial-based systems therapy disease treatment. Herein, we recent developments modalities Additionally, discuss acid strategies, focus systems. Furthermore, current applications summarized.
Язык: Английский
Процитировано
33
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 196, С. 114781 - 114781
Опубликована: Март 20, 2023
Язык: Английский
Процитировано
32
Smart Molecules, Год журнала: 2024, Номер 2(1)
Опубликована: Март 1, 2024
Abstract This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, classification hydrogels, explores synthesis responsive capabilities. Specific examined encompass topical drug delivery, contact lenses, intravitreal ocular adhesives, vitreous substitutes, cell‐based therapy. A methodical analysis, including an overview relevant structures comparative evaluation hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, research areas are identified. Our approach, guided by extensive literature from 2017 to 2023, illuminates unprecedented opportunities offered along pinpointing for further inquiry facilitate transition clinical practice.
Язык: Английский
Процитировано
10
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 1022 - 1028
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Pharmaceutics, Год журнала: 2022, Номер 14(8), С. 1605 - 1605
Опубликована: Июль 31, 2022
This review offers the basics of lentiviral vector technologies, their advantages and pitfalls, an overview use in field ophthalmology. First, description global challenges encountered to develop safe efficient recombinant vectors for clinical application is provided. The risks measures taken minimize secondary effects as well new strategies using these are also discussed. then focuses on specifically designed ocular therapy goes over preclinical studies describing safety efficacy. A therapeutic approach vector-mediated gene currently being developed many diseases, e.g., aged-related macular degeneration, retinopathy prematurity, inherited retinal dystrophies (Leber congenital amaurosis type 2, Stargardt disease, Usher syndrome), glaucoma, corneal fibrosis or engraftment rejection. In summary, this shows how offer interesting alternative all compartments.
Язык: Английский
Процитировано
29
Molecular Pharmaceutics, Год журнала: 2023, Номер 20(11), С. 5359 - 5382
Опубликована: Сен. 28, 2023
Local drug delivery to the eye through conventional means has faced many challenges due three essential barriers: (a) complex structure of cornea limiting absorption, (b) capacity ocular absorptive cells in metabolism, and (c) washing effect tears. Polymeric micelles (PMs) have been focus much interest for several advantages they provide this application, including solubilization hydrophobic drugs, nonirritability, nanoscopic diameter, clarity their aqueous solution not interfering with vision. The potential increase release residence time incorporated medication at site absorption is also a bonus advantage these systems. This Review covers research conducted on single or mixed prepared from small amphiphilic molecules, copolymers (diblock, triblock, graft), gel systems containing micelles. purpose review an update status micellar different indications, preclinical clinical development. In context, we are discussing anatomy eye, various barriers, formulations, benefits delivery, as well role PMs management diseases both models clinic. encouraging effectiveness findings experiments laboratory settings live animals paved way advancement trials administration first nanomicallar formulation approved use by United States Food Drug Administration (marketed Cequa Sun Pharmaceuticals).
Язык: Английский
Процитировано
17
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 97 - 108
Опубликована: Янв. 1, 2024
Abstract: The cornea, as the outermost layer of eye, plays a crucial role in vision by focusing light onto retina. Various diseases and injuries can compromise its clarity, leading to impaired vision. This review aims provide thorough overview pharmacological properties, therapeutic potential associated risks Rho-associated protein kinase (ROCK) inhibitors management corneal diseases. article focuses on four key ROCK inhibitors: Y-27632, fasudil, ripasudil, netarsudil, providing comparative examination. Studies supporting use highlight their efficacy across diverse conditions. In Fuchs' endothelial dystrophy, studies application netarsudil demonstrated noteworthy enhancements cell density, visual acuity. pseudophakic bullous keratopathy, injection Y-27632 together with cultured cells into anterior chamber lead enhanced density improved Animal models simulating chemical injury cornea showed reduction neovascularization epithelial defects after fasudil case iridocorneal syndrome edema. Addressing safety considerations, both clinically approved, exhibit adverse events such conjunctival hyperemia, hemorrhage, verticillata, conjunctivitis, blepharitis. Monitoring patients during treatment becomes balancing benefits these risks. conclusion, inhibitors, particularly offer promise managing analysis properties underscore significance. However, ongoing research is paramount comprehensively understand profiles long-term outcomes conditions, guiding optimal clinical practice. Keywords: rho diseases, dystrophies, transplantation
Язык: Английский
Процитировано
7
World Journal of Virology, Год журнала: 2024, Номер 13(1)
Опубликована: Март 11, 2024
The aim of our minireview is to provide a brief overview the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type corneal viral infection caused by virus (HSV), which can affect several tissues, including cornea. One significant aspect HSK its potential cause recurrent episodes inflammation damage After initial infection, HSV establish latent in trigeminal ganglion, nerve cluster near eye. may remain dormant for extended periods. Periodic reactivation occur, leading HSK. Factors triggering include stress, illness, immunosuppression, or trauma. Recurrent manifest different patterns, ranging from mild epithelial involvement more severe stromal endothelial disease. severity frequency recurrences vary among individuals. Severe cases HSK, especially those involving stroma scarring, result vision impairment even blindness extreme cases. cornea's clarity crucial good vision, scarring compromise this, potentially visual impairment. management involves not only treating acute but also implementing long-term strategies prevent attempt repairs endings via neurotization. Antiviral medications, such as oral Acyclovir topical Ganciclovir, be prescribed prophylaxis. immune response contribute damage. Inflammation, body's control inadvertently harm tissues. Clinicians should informed about triggers advised on measures minimize risk reactivation. In summary, nature underscores importance both preserve health maintain optimal function.
Язык: Английский
Процитировано
6