Bohn Stafleu van Loghum eBooks, Год журнала: 2022, Номер unknown, С. 597 - 616
Опубликована: Янв. 1, 2022
Journal of Trauma and Acute Care Surgery, Год журнала: 2023, Номер 95(5), С. 790 - 799
Опубликована: Авг. 8, 2023
In Brief Export A review of UF SCIRC's research efforts characterizing CCI, PICS biomarkers, effect site infection, acute kidney injury, effects on older patients, dysfunctional high-density lipoproteins, sarcopenia/cachexia, emergency myelopoiesis, and dysregulated erythropoiesis.
Язык: Английский
Процитировано
19
International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(3), С. 1808 - 1808
Опубликована: Фев. 5, 2022
Population aging and urban development pose major challenges for societies today. Joining the literature assessing accessibility, present exploratory research developed a multivariate accessibility model based on four independent variables-related to formal structural space-that influence walkability older adults (pedestrian network; facilities shops; public benches; slopes gradients). The used ArcGIS software. For calculations, we selected two suburban neighborhoods in conurbation of Grenoble (France) three types adults' profiles reflect variety aging: an adult good health, with chronic disease, reduced mobility. results suggest that neighborhood depends not only its physical characteristics, but it is also influenced by health characteristics inhabitants. originality lies mainly ability estimate spatial territory taking into account, firstly, objective data such as built environment through objectification variables consider original presence benches or gradients and, secondly, specific and/or study population. measurement geospatial could be great value contexts, which why relevant tools methodologies are needed objectively examine intervene spaces order make them age-friendly.
Язык: Английский
Процитировано
14
BMC Geriatrics, Год журнала: 2021, Номер 21(1)
Опубликована: Ноя. 19, 2021
Mobility decrease leading to disability can gradually develop during early life, however, its related factors are not well clarified. Therefore, we investigate the of mobility at various levels, using nationwide data in Japan.In total, 8681 independent community dwellers aged 20-89 years were analysed (average age, 51.6 years; 58.5% women). Three stages based on locomotive syndrome risk test: Stage 1, emerging; 2, progressing; 3, progressed restrict social engagement. Age was a simple quadratic function model.The prevalence Stages 1-3 31.6% (n = 2746), 5.8% 504), and 3.2% 278), respectively. On multivariable logistic regression, increased age participants ≥40 (stage 1: odds ratio[OR] 1.05-1.20, stage 2: OR 1.04-1.22, 3: 1.05-1.22), female 2.28, 95% confidence interval [CI] 1.99-2.61, 2.40, CI 1.77-3.25, 1.80, 1.19-2.72), overweight status 1.56, 1.34-1.82, 3.19, 2.38-4.27, 2.87, 1.90-4.32), hypertension 1.20, 1.01-1.41, 1.99, 1.49-2.64, 2.10, 1.44-3.05), diabetes mellitus 1.62, 1.17-2.24, 1.57, 0.93-2.66, 1.13-3.90) positively associated. The frequency physical activity/sports, even few per month, inversely associated with all 0.59-0.72, 0.50-0.67, 0.36-0.53). A one-year increase had stronger impact older adults than younger ones. Increased < 40 smoking while intake foods 1 2.Increased (< years) emerging decrease, that (≥ any levels decrease. Female, lifestyle habits, including activities status, every level.
Язык: Английский
Процитировано
19
BMC Medicine, Год журнала: 2021, Номер 19(1)
Опубликована: Ноя. 24, 2021
Abstract Background Dietary biomarkers may complement dietary intake assessment made by questionnaires. We developed an a-posteriori score based on Mediterranean diet food groups and evaluated its association with mortality. Methods 642 participants (56% female), aged ≥65 years, complete data were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes all-cause, cardiovascular, cancer selected from literature correlation analyses intakes of study. baseline levels following chosen: urinary total polyphenols resveratrol metabolites, plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic docosahexaenoic acids, mono-unsaturated/saturated fatty acid ratio. Associations using a validated frequency questionnaire (FFQ) (as tertiles) mortality assessed through Cox regression. Results During 20-year follow-up [median (Q1–Q3), 14 (8–18) years], 435 deaths occurred (139 cardiovascular diseases 89 cancer-related causes). In fully adjusted models, biomarker-Mediterranean was inversely associated all-cause (HR T3vs.T1 0.72; 95%CI 0.56–0.91) 0.60; 0.38–0.93), but not between FFQ-Mediterranean statistically significant. Conclusions A greater adherence at to biomarker lower risk older adults follow-up. measurement contribute guide individualized counseling people. Trial registration NCT01331512
Язык: Английский
Процитировано
17
The Journal of Frailty & Aging, Год журнала: 2022, Номер unknown
Опубликована: Янв. 1, 2022
Язык: Английский
Процитировано
11
BMC Public Health, Год журнала: 2023, Номер 23(1)
Опубликована: Авг. 28, 2023
Abstract Background In older adults, mobility is important for maintaining their independence and quality of life, it influences physical, cognitive, social health. This study aimed to identify the physical psychosocial factors that affected community-dwelling aged 65 years or older, who were socially isolated during coronavirus disease 2019 (COVID-19) pandemic due stay-at-home policies. Methods The participants in this 214 adults Korea, a cross-sectional survey was conducted from December 2020 January 2021. Variables included participants’ general characteristics, mobility, sitting time, depression, support, cognitive function. Results Multiple linear regression analysis showed influencing adults’ COVID-19 depression (β=-0.29, p < .001), age (65–74 old) (β = 0.19, .002), lower level education (β=-0.17, .006), two more comorbidities (β=-0.18, time .004), ability drive vehicle 0.14, .017). Conclusions Home healthcare interventions are needed limit issues improve had limited pandemic.
Язык: Английский
Процитировано
5
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2715 - 2715
Опубликована: Фев. 27, 2024
Obesity, a complex disorder with rising global prevalence, is chronic, inflammatory, and multifactorial disease it characterized by excessive adipose tissue accumulation associated comorbidities. Adipose (AT) an extremely diverse organ. The composition, structure, functionality of AT are significantly influenced characteristics specific to everyone, in addition the variability connected various types its location-related heterogeneity. Recent investigation has shed light on intricate relationship between bone marrow stem cells obesity, revealing potential mechanisms that contribute development consequences this condition. Mesenchymal within marrow, known for their multipotent differentiation capabilities, play pivotal role adipogenesis, process fat cell formation. In context alterations microenvironment may influence mesenchymal towards adipocytes, impacting overall storage metabolic balance. Moreover, marrow's as crucial component immune system adds another layer complexity obesity-bone interplay. This narrative review summarizes current research findings connection highlighting multifaceted roles adipogenesis inflammation.
Язык: Английский
Процитировано
1
Frontiers in Physiology, Год журнала: 2024, Номер 15
Опубликована: Авг. 2, 2024
Physical inactivity can lead to frailty and negative health outcomes in middle-aged older adults. Sedentary individuals have double the risk of death compared those who engage high levels physical activity (PA). The advantages practicing PA age are significant, with regular, moderate-intensity (150 min per week)being consistently linked a decreased chronic disease, cognitive decline, mortality. Therefore, study aimed carry out bibliometric review related terms “Physical activity,” “Functional capacity” “Aging” including all documents published Web Science Core Collection until 31st December 2023. sample was made up 231 studies topic. results reported that first document 1994. However, there no continuity publication till 1998, which year at least one published. Considering 1998 as year, it is observed an exponential growth 77.4%, between oldest (1997–2008) contemporaneous (2008–2023), “Geriatric Gerontology” category highest number (n = 59). journal “Experimental associated largest 7), being indexed Quartil 2. years 2009 had citations 1811), total 7 2018 higher 25). These importance elderly people, how influences falls, improving balance functional capacity. Thus, important programmes promote this population reduce falls presence diseases.
Язык: Английский
Процитировано
1
Advances in Human Biology, Год журнала: 2024, Номер 14(4), С. 261 - 268
Опубликована: Авг. 29, 2024
Gerontology, the scientific study of ageing and its associated challenges, has emerged as a crucial field research practice in recent decades. With global population at an unprecedented rate, significance gerontology cannot be overstated. The World Health Organization (WHO) projects that by 2050, number people aged 60 years older will double, reaching 2 billion, constituting over 20% world's population.[1] This demographic shift is primarily driven advancements healthcare technology, which have significantly increased life expectancy.[2] However, it also presents myriad including prevalence chronic diseases, mental health issues need for long-term care.[3] importance lies comprehensive approach to understanding biological, psychological social aspects ageing. It encompasses wide range disciplines, from molecular biology genetics sociology economics, aiming improve quality adults.[4] Research led significant our process development interventions promote healthy ageing.[5] instance, studies shown lifestyle factors such diet, exercise engagement can considerably impact onset age-related diseases.[6] purpose this editorial highlight current trends, challenges future directions gerontology. As ages, we must address multifaceted needs adults through innovative research, effective policies care strategies.[2,7] delve into historical evolution gerontology, examine latest field, propose practice. By fostering deeper better prepare changes ahead ensure higher population.[8,9] HISTORICAL PERSPECTIVE: EVOLUTION OF GERONTOLOGY AS A DISCIPLINE evolved past century, transforming niche area comprehensive, multidisciplinary addresses complex population. traced back early 20th with key milestones breakthroughs marking progress. Gerontology distinct discipline 1900s, increasing recognition unique stage requiring specialised care.[10] establishment first geriatric hospital United Kingdom Dr. Marjory Warren 1930s was milestone, highlighting adults.[11] Warren's work laid foundation modern geriatrics, emphasising assessment individualised people.[12] In mid-20th expanded focus include medical dimensions.[13] Gerontological Society America (GSA) 1945 marked pivotal moment, providing platform researchers practitioners collaborate advance field.[14] GSA's interdisciplinary underscored necessity integrating perspectives nature Fundamental occurred latter half century. discovery genetic basis ageing, identifying genes longevity, opened new avenues research.[15] Studies on cellular senescence role telomeres provided critical insights biological mechanisms underlying process.[16] These discoveries paved way developing delay extend span. late 21st centuries witnessed technological innovations funding research. Establishing National Institute Aging (NIA) States 1974 supporting diseases.[17] NIA's initiatives important discoveries, identification biomarkers therapies conditions.[18] Recent focused application technology well-being adults. Advances genomics, proteomics bioinformatics enhanced facilitated personalised interventions.[19,20] addition, care, telehealth wearable devices, revolutionised how delivered adults, improving access enabling more management conditions.[21] Despite these advancements, remain Addressing determinants health, combating ageism ensuring equitable all are require ongoing attention.[22] strong foundation, but continued efforts needed evolving CURRENT TRENDS AND CHALLENGES today shaped several trends shifts, advances persistent difficulties care. Demographic shifts their implications One gerontology's most profound towards Multiple reported proportion growing faster than any other age groups, trend expected continue decades.[1,23] increase declining fertility rates rising expectancy, resulting poses social, economic challenges.[24] vast, ranging demand services age-friendly infrastructure support adults' independence life.[25] dramatically transformed offering tools complexities senescence, inflammation factors.[26] novel therapeutic strategies prevent diseases.[27] For targeting senescent cells promise extending span function tissues.[28] Technological delivered. rise telemedicine, devices smart home technologies ability monitor manage conditions remotely, adults.[29] facilitate timely independent living proactively.[30] adopting requires addressing barriers digital literacy, accessibility affordability they benefit segments population.[31] Critical Several persist despite advancements. primary diseases amongst Conditions cardiovascular disease, diabetes dementia common population, necessitating continuous strategies.[32] Managing multiple coordinated interplay between individual's well-being.[33] Another challenge shortage professionals trained geriatrics. growing, yet notable gap exists workforce equipped meet demand.[34] exacerbated fact often time resources younger populations, investment training education providers.[35] Factors socio-economic status, healthcare, play outcomes people.[36] Interventions essential reducing disparities promoting equity care.[37] INNOVATIONS IN remarkable years, findings, models reshaping Notable findings hallmarks genomic instability, telomere attrition, epigenetic alterations loss proteostasis, others.[38] Understanding targeted reduce disease incidence.[39] highlighted [Figure 1]. Regular physical activity, balanced diet reduced risk cognitive adults.[40] gut microbiome revealed influencing inflammation, metabolism overall health.[41] underscore potential medicine adults.[42]Figure 1: Lifestyle Image credit: Nor Faiza Mohd. Tohit.Technological monitor, enhance Telehealth vital innovation, particularly after COVID-19 pandemic, remote in-person visits.[43] been conditions, patient satisfaction or underserved areas.[44] Wearable another advancement, continuously monitoring signs, activity metrics.[45] Devices smartwatches fitness trackers enable track real receive when necessary.[46] data collection researchers, valuable patterns outcomes.[47] Smart technologies, sensors automated systems, developed daily activities, detect falls provide reminders medication, enhancing safety autonomy.[48] Integrating artificial intelligence (AI) systems further enhances capabilities, predictive analytics care.[49] New Innovations community's 2]. model patient-centred (PCMH), emphasises coordinated, team providers.[50] PCMH improved outcomes, hospitalisations population.[51] integrated pathways (ICPs), structured, approaches managing conditions.[52] ICPs consistent, high-quality across settings, services.[53] communication collaboration providers, coordination continuity.[54] Community-based gained prominence, focusing delivering community settings. Programmes All-Inclusive Care Elderly them live independently while receiving need.[55,56] emphasise ageing.[56]Figure 2: Holistic elderly. Tohit.POLICY PRACTICE IMPLICATIONS policy, best practices professionals. areas effectively Impact policy necessitates substantial met. Policies WHO advocated prioritise integrate healthcare.[57] Such implementing preventive measures, lifestyles populations.[58] Healthcare financial costs pose many whom fixed incomes. expenses, subsidies medications insurance, burden families.[59] should adoption delivery population.[60] Best Implementing Comprehensive (CGA) considered cornerstone CGA involves multidimensional evaluation adult's medical, functional leading plan.[61] adults.[62] Person-centred preferences, values needs, tailored each person's circumstances.[63] active families develop implement plans respect autonomy dignity.[64] Evidence suggests person-centred lead adherence treatment plans.[65] Interdisciplinary team-based various professionals, physicians, nurses, workers therapists, communities.[66] teams coordination, provider addressed.[67] Training underscores Geriatric programmes nursing curricula equip providers knowledge skills necessary adults.[68] cover syndromes principles care.[69] Continuing professional opportunities providers. Workshops, seminars certification help stay updated advancements.[70] foster adults.[71] FUTURE DIRECTIONS poised emerging areas, collaborative policymakers take centre stage. sustained commitment stakeholders. Emerging hold advancing 3].[72,73] diseases.[74] Researchers exploring contribute tissue dysfunction intending selectively eliminate ageing.[75-77] promising investigation composition age, immune function, health.[78] could restore mitigate issues. geroscience, explores relationship gaining traction. Geoscientific aims identify drive conditions.[61,79] Genomics tailor profile.[80]Figure 3: Areas Gerontology. Tohit.Potential revolutionise breakthrough senolytic drugs, target cells. Preclinical senolytics lifespan animal models.[81] Clinical trials underway evaluate efficacy drugs humans, transform diseases.[82] using AI machine learning analyse large datasets predict proactive care.[61,83] example, algorithms signs decline falls, allowing adverse outcomes.[84] Furthermore, regenerative made.[85] CALL TO ACTION FOR RESEARCHERS, POLICYMAKERS PRACTITIONERS To realise full breakthroughs, concerted effort practitioners. translating practical interventions.[86] Collaborative, Policymakers creating environment 4]. includes security invest gerontology.[87] health-related throughout individuals.[83] Practitioners, caregivers, adopt informed about high-quality, adults.[88,89] Practitioners advocate patients, responsive population's needs.Figure 4: Key Policy Advocacy Supports Healthy Ageing. Tohit.The characterised opportunities. leverage practitioners, create society supports members, healthy, fulfilling lives. Consent publication author reviewed approved final version agreed accountable work, accuracy integrity Disclosure declares do not involvement affiliations organisation, association entity directly indirectly related subject matter materials presented editorial. honoraria, expert testimony, employment, ownership stocks options, patents grants received pending royalties. Data availability Information taken freely available sources Authorship contribution All authors contributed whether conception, design, utilisation, collection, analysis interpretation areas. They participated paper's drafting, revision, review, gave approval would published, decided journal article submitted, made responsible decision held work.
Язык: Английский
Процитировано
1
Mechanisms of Ageing and Development, Год журнала: 2024, Номер 222, С. 111997 - 111997
Опубликована: Окт. 11, 2024
Osteosarcopenia is a major driver of functional loss and risk factor for falls, fractures, disability mortality in older adults, urgently requiring the development effective interventions to address it. The hallmarks aging provide theoretical practical framework that allows structured organization current knowledge planning new lines. This article comprehensively reviews currently available literature on role osteosarcopenia, thereby offering panoramic view state art gaps this field.
Язык: Английский
Процитировано
1