Possible Mechanisms of Dark Tea in Cancer Prevention and Management: A Comprehensive Review

Nutrients, Год журнала: 2023, Номер 15(18), С. 3903 - 3903

Опубликована: Сен. 7, 2023

Tea is one of the most popular drinks in world. Dark tea a kind post-fermented with unique sensory characteristics that produced by special fermentation microorganisms. It contains many bioactive substances, such as polyphenols, theabrownin, polysaccharides, etc., which have been reported to be beneficial human health. This paper reviewed latest research on dark tea’s potential preventing and managing cancer, mechanisms mainly involved anti-oxidation, anti-inflammation, inhibiting cancer cell proliferation, inducing apoptosis, tumor metastasis, regulating intestinal flora. The purpose this review accumulate evidence anti-cancer effects tea, corresponding limitations for prevention management, future prospects, demanding questions about possible contributions an adjuvant.

Язык: Английский

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Recent advances in tea seeds (Camellia Sinensis (L.) O. Kuntze): Active ingredients, health effects, and potential applications

Trends in Food Science & Technology, Год журнала: 2023, Номер 141, С. 104192 - 104192

Опубликована: Окт. 4, 2023

Язык: Английский

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Epigallocatechin-3-gallate mitigates cadmium-induced intestinal damage through modulation of the microbiota-tryptophan-aryl hydrocarbon receptor pathway

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 280, С. 116520 - 116520

Опубликована: Июнь 3, 2024

Early studies have shown that the gut microbiota is a critical target during cadmium exposure. The prebiotic activity of epigallocatechin-3-gallate (EGCG) plays an essential role in treating intestinal inflammation and damage. However, exact barrier protection mechanism EGCG against exposure remains unclear. In this experiment, four-week-old mice were exposed to (5 mg kg

Язык: Английский

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Pu-erh tea theabrownin improves the ovarian function and gut microbiota in laying hens

Poultry Science, Год журнала: 2024, Номер 103(7), С. 103795 - 103795

Опубликована: Апрель 24, 2024

Studies have reported that theabrownin can moderate the lipid metabolism and intestinal microbiota, thereby affecting health of humans model animals, however research on laying hens is scarce. The present study aimed to investigate effects dietary supplementation metabolism, microbial composition ovarian function in hens. A total 80 (25 wk age) were fed with normal diet (CON) +100 mg/kg (PT group) for 12 wk. results showed addition enhanced villus height duodenum decreased crypt depth jejunum (P < 0.05). At same time, compared CON, concentration IL-6 mRNA expression IL-1β significantly PT group Dietary reduced cholesterol glycerol, while droplet optical density liver Compared CON group, PPARγ, HMG-CoAS, ACC down-regulated CYP8B1 was up-regulated ACE, Chao1 Observed_species indexes cecum microbiota increased by intervention relative abundance Firmicutes (phylum), Lactobacillus (genus) Bacteroidetes ratio, (phylum) organic acids its derivatives serum metabolites resulted higher Bcl-2 SIRT1 ovary estradiol These discovering indicated influenced improving morphology, community structure reducing inflammatory cytokines intestine. hepatic deposition it also cell apoptosis rate improve egg weight which associated pathway.

Язык: Английский

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The Aroma Compounds Contributing to the Characteristic Flavour of Ripe Pu-erh Tea and Their Molecular Mechanisms of Interaction with Olfactory Receptors

LWT, Год журнала: 2025, Номер unknown, С. 117808 - 117808

Опубликована: Апрель 1, 2025

Язык: Английский

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Health-promoting functions and related comprehensive molecular mechanisms of tea: from the perspectives of anti-inflammatory, lipid-lowering, glucose-lowering and anti-cancer effects

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106769 - 106769

Опубликована: Май 1, 2025

Язык: Английский

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Liupao tea aqueous extract alleviates dextran sulfate sodium-induced ulcerative colitis in rats by modulating the gut microbiota

Open Life Sciences, Год журнала: 2025, Номер 20(1)

Опубликована: Янв. 1, 2025

Abstract Liupao tea is known for its anti-inflammatory antioxidant and regulation of gut microecological balance properties. This study aims to investigate the therapeutic effects aqueous extract (LPTAE) on ulcerative colitis (UC) induced by dextran sulfate sodium (DSS) in rats. The rats were randomly divided into five groups: Normal group, DSS LPTL LPTM LPTH group. Throughout experiment, rats’ activity levels, stool consistency, body weights observed recorded daily. After colon length was measured, tissues collected pathological analysis. Additionally, contents analyzed microbiota composition short-chain fatty acid (SCFA) level, while serum samples determine inflammatory oxidative factors. results indicated that treatment with low, medium, high doses LPTAE significantly inhibited weight loss, alleviated rectal bleeding, reduced shortening compared It also decreased disease index histopathological scores Furthermore, levels cytokines such as IL-1 β , IL-6, TNF- α malondialdehyde, simultaneously increasing superoxide dismutase SCFAs, including acetic acid, propionic butyric acid. 16S rDNA gene sequencing revealed all reversed decrease both diversities caused UC, increased relative abundance beneficial bacteria Lactobacillus Muribaculaceae, Alloprevotella Blautia harmful Prevotella Romboutsia Bacteroides . In summary, within tested (100, 150, 250 mg/kg), DSS-induced modulating correcting metabolic imbalance SCFAs.

Язык: Английский

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Yellow Teas Protect against DSS-Induced Ulcerative Colitis by Inhibiting TLR4/NF-κB/NLRP3 Inflammasome in Mice

Foods, Год журнала: 2024, Номер 13(17), С. 2843 - 2843

Опубликована: Сен. 7, 2024

Yellow tea (YT), a slightly fermented with unique yellowing process and mellow taste, is becoming widely popular. Currently, the YT includes bud yellow (BYT), small-leaf (SYT), large-leaf (LYT) based on maturity of raw materials. Previous studies have shown that has outstanding potential in preventing metabolic syndrome. However, distinct effects mechanisms different types ulcerative colitis (UC) are still unclear. This study investigated continuous or intermittent intervention three water extracts (YTEs) dextran sulfate sodium (DSS)-induced CD-1 mice. The results showed YTE significantly improves syndrome DSS-induced UC Mechanistic reveal YTEs increase expression levels tight junction (TJ) proteins reduce pro-inflammatory cytokines colon by inactivating TLR4/NF-κB/NLRP3. treatment protected intestinal barrier integrity reduced serum lipopolysaccharide (LPS) levels. Interestingly, our indicate better alleviating effect than BYT SYT. before DSS administration certain degree preventive colitis, while after induction significant reversing damage caused DSS. Our indicated drinking may therapeutic UC, especially LYT.

Язык: Английский

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Liubao insect tea polyphenols ameliorate DSS-induced experimental colitis by protecting intestinal barrier and regulating intestinal microbiota

Food Chemistry, Год журнала: 2024, Номер unknown, С. 142156 - 142156

Опубликована: Ноя. 1, 2024

Язык: Английский

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Black tea preserves intestinal homeostasis through balancing barriers and microbiota in mice

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Май 21, 2024

Introduction Black tea, a beverage consumed worldwide, possesses favorable effects on gastrointestinal tract, including nourishing stomach and promoting digestion. Nevertheless, its specific intestinal homeostasis remains inconclusive. Methods We applied black tea to mice prior inducing colitis with DSS then monitored their body weight disease activity index (DAI) daily. When sacrificed, we measured permeability conducted analyses of mucin tight junction proteins. detected inflammatory cytokines, immune cells, related signaling pathways. In addition, the gut microbiota was analyzed through 16S rRNA sequencing, concentrations short-chain fatty acids (SCFAs) were also measured. Results The results showed that tea-treated group significantly rescued DSS-disrupted structure. It reduced relative abundance pathogenic bacterium Turicibacter , while increased beneficial bacteria norank_f_Muribaculaceae restored contents SCFAs such as acetate, propionate, butyrate. protected barrier by reducing levels response-related factors (e.g., TNF-α, IL-6, IL-1β) increasing expression proteins (TJs) ZO-1, occludin). Furthermore, exhibited capacity suppress MMP-9 ICAM-1 well inhibit activation NF-κB pathway. Discussion Our findings provide theoretical framework elucidates mechanisms which preserves homeostasis, highlighting potential preventive strategy against disruptions. This study contributes understanding dietary health.

Язык: Английский

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