Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Дек. 19, 2024
Apigenin (C
Язык: Английский
Fish & Shellfish Immunology, Год журнала: 2023, Номер 140, С. 108995 - 108995
Опубликована: Авг. 11, 2023
Язык: Английский
Процитировано
47
Phytochemistry, Год журнала: 2024, Номер 219, С. 114002 - 114002
Опубликована: Янв. 27, 2024
Язык: Английский
Процитировано
13
Neural Regeneration Research, Год журнала: 2024, Номер 20(3), С. 613 - 631
Опубликована: Март 1, 2024
Alzheimer’s disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, cure for has not yet been found. Oxidative stress mediates excessive oxidative responses, its involvement in pathogenesis as primary or secondary pathological event widely accepted. As member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With discovery ferroptosis, central role anti-lipid peroxidation several diseases, including disease, received widespread attention. Increasing evidence suggests that expression inhibited brain, resulting stress, inflammation, apoptosis, which are closely associated damage disease. Several therapeutic approaches, such small molecule drugs, natural plant products, non-pharmacological treatments, ameliorate cognitive function by promoting enhancing activity. Therefore, upregulation may be promising strategy treatment This review provides overview gene structure, biological functions, regulatory mechanisms 4, discussion on important events related summary advances small-molecule therapies targeting Most prior studies this subject used animal models, relevant clinical lacking. Future trials required validate effects strategies
Язык: Английский
Процитировано
9
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Янв. 24, 2025
Abstract Environmental pollution represents a significant public health concern, with the potential risks associated environmental pollutants receiving considerable attention over an extended period. In recent years, substantial body of research has been dedicated to this topic. Since discovery ferroptosis, iron-dependent programmed cell death typically characterized by lipid peroxidation, in 2012, there have advances study its role and mechanism various diseases. A growing number studies also demonstrated involvement ferroptosis damage caused organism pollutants, molecular mechanisms involved partially elucidated. The targeting be effective means ameliorating PM2.5, organic inorganic ionizing radiation. This review begins providing summary most important ferroptosis. It then proceeds offer critical analysis effects induced pollutants. Furthermore, as is case all rapidly evolving areas, are numerous unanswered questions challenges pertaining pollutant-induced which we discuss attempt provide some directions clues for future field.
Язык: Английский
Процитировано
1
Plants, Год журнала: 2022, Номер 11(13), С. 1680 - 1680
Опубликована: Июнь 24, 2022
Oxidative stress is among the major triggers for many important human functional disorders, which often lead to various metabolic or tissue diseases. The aim of study obtain five standardized vegetal extracts (
Язык: Английский
Процитировано
30
Environmental Toxicology, Год журнала: 2023, Номер 38(6), С. 1226 - 1238
Опубликована: Март 8, 2023
Abstract Di(2‐ethylhexyl) phthalate (DEHP) is a plasticizer and an endocrine disruptor. Microplastics (MPs) are pathogenic small plastic particles abundant in the aqueous environment. The problem of residual hazards products worthy study, especially joint exposure variety plastic‐related to toxic effect. We used 200 mg/kg DEHP 10 mg/L MPs establish model vivo 2 mM μg/L AML12 cell vitro. In study results showed that compared with control group (NC) group, significantly increased contents malondialdehyde hydrogen peroxide, decreased glutathione activity superoxide dismutase, total antioxidant capacity, catalase peroxidase. level oxidative stress was further aggravated after combined exposure. reactive oxygen species exposed vitro higher than NC single also confirmed could increase mRNA protein levels apoptosis markers necroptosis there additive After N‐acetylcysteine treatment vitro, above‐mentioned damage significantly. This provided reference for advocating reduction mixed use products, basis preventing harm residues.
Язык: Английский
Процитировано
19
Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер unknown
Опубликована: Апрель 7, 2023
Flavonoids are a class of bioactive phytochemicals containing core 2-phenylchromone skeleton and widely found in fruits, vegetables, herbs. Such natural compounds have gained significant attention due to their various health benefits. Ferroptosis is recently discovered unique iron-dependent mode cell death. Unlike traditional regulated death (RCD), ferroptosis associated with excessive lipid peroxidation on cellular membranes. Accumulating evidence suggests that this form RCD involved variety physiological pathological processes. Notably, multiple flavonoids been shown be effective preventing treating diverse human diseases by regulating ferroptosis. In review, we introduce the key molecular mechanisms ferroptosis, including iron metabolism, several major antioxidant systems. Additionally, summarize promising targeting which provides novel ideas for management such as cancer, acute liver injury, neurodegenerative diseases, ischemia/reperfusion (I/R) injury.
Язык: Английский
Процитировано
18
Antioxidants, Год журнала: 2024, Номер 13(3), С. 334 - 334
Опубликована: Март 10, 2024
Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.
Язык: Английский
Процитировано
6
Journal of Environmental Sciences, Год журнала: 2024, Номер 148, С. 13 - 26
Опубликована: Янв. 21, 2024
Язык: Английский
Процитировано
5
Antioxidants, Год журнала: 2024, Номер 13(3), С. 352 - 352
Опубликована: Март 15, 2024
Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation ferrous ions (Fe2+) and lipid peroxides. As metabolic hub body, liver crucial for iron storage metabolism. The seems to be closely related ferroptosis through Liver disease greatly threatens host health, exploring effective interventions essential. Mounting studies have demonstrated that one possible pathogenic mechanisms involved in disease. Targeting may provide a promising opportunity treating However, drugs targeting are extremely limited. Therefore, it urgent need develop new safe regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, recently shown great therapeutic potential via modulating ferroptosis-related genes or pathways. Here, we outline molecular mechanism systematically summarize regulatory function NAC on Finally, discuss application prospects problems concerning as regulators managing
Язык: Английский
Процитировано
5