Esculin inhibits hepatic stellate cell activation and CCl4-induced liver fibrosis by activating the Nrf2/GPX4 signaling pathway

Phytomedicine, Год журнала: 2024, Номер 128, С. 155465 - 155465

Опубликована: Фев. 17, 2024

Язык: Английский

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Myricetin Induces Ferroptosis and Inhibits Gastric Cancer Progression by Targeting NOX4

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(12), С. 6178 - 6188

Опубликована: Март 14, 2024

Ferroptosis holds great potential as a therapeutic approach for gastric cancer (GC), prevalent and deadly malignant tumor associated with high rates of incidence mortality. Myricetin, well-known its multifaceted biomedical attributes, particularly anticancer properties, has yet to be thoroughly investigated regarding involvement in ferroptosis. The aim this research was elucidate the impact myricetin on ferroptosis GC progression. present study observed that could trigger cells by enhancing malondialdehyde production Fe2+ accumulation while suppressing glutathione levels. Mechanistically, directly interacted NADPH oxidase 4 (NOX4), influencing stability inhibiting ubiquitin degradation. Moreover, regulated inhibition induced Helicobacter pylori cytotoxin-associated gene A (CagA) through NOX4/NRF2/GPX4 pathway. In vivo experiments demonstrated treatment significantly inhibited growth subcutaneous tumors BALB/c nude mice. It accompanied increased NOX4 expression tissue suppression NRF2/GPX4 antioxidant Therefore, underscores novel inducer interaction NOX4. is promising candidate treatment.

Язык: Английский

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Crosstalk between ROS-inflammatory gene expression axis in the progression of lung disorders

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Язык: Английский

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Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via Nrf2/SLC7A11/GPX4 signaling pathway

Chemico-Biological Interactions, Год журнала: 2023, Номер 388, С. 110835 - 110835

Опубликована: Дек. 18, 2023

Язык: Английский

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Natural flavonoids act as potent ferroptosis inhibitors and their potentials in the treatment of ferroptosis-associated diseases

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100377 - 100377

Опубликована: Янв. 26, 2024

Ferroptosis, an iron-dependent cell death characterized by lethal lipid peroxidation, has been involved in the pathogenesis of various diseases, such as ischemia/reperfusion injury, neurodegenerative and inflammatory disorders. Pharmacological inhibition ferroptosis represents a promising strategy for treatment above diseases. Flavonoids, class natural products found medicinal plants functional foods, are known numerous activities, especially newly discovered anti-ferroptotic activity. Our review aims to expand our understanding flavonoids' activity on multiple biological systems highlight importance utilizing flavonoids ferroptosis-associated A systematic literature search was conducted using Google Scholar, PubMed, Web Science, ScienceDirect, Springer Link. The following keywords: flavonoids, products, ferroptosis, mechanism, available information comprehensively studied compiled. We recent advances molecular mechanisms its roles diverse further systematically summarize inhibitory underlying suggest that ROS accumulation labile Fe2+ availability well activation Nrf2 signaling responsible inhibition. also discuss their clinical applications ferroptosis-related Taken together, exhibit prospect This is expected not only facilitate design development flavonoid-based inhibitors, but diseases therapies.

Язык: Английский

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Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications

Antioxidants, Год журнала: 2024, Номер 13(3), С. 352 - 352

Опубликована: Март 15, 2024

Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation ferrous ions (Fe2+) and lipid peroxides. As metabolic hub body, liver crucial for iron storage metabolism. The seems to be closely related ferroptosis through Liver disease greatly threatens host health, exploring effective interventions essential. Mounting studies have demonstrated that one possible pathogenic mechanisms involved in disease. Targeting may provide a promising opportunity treating However, drugs targeting are extremely limited. Therefore, it urgent need develop new safe regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, recently shown great therapeutic potential via modulating ferroptosis-related genes or pathways. Here, we outline molecular mechanism systematically summarize regulatory function NAC on Finally, discuss application prospects problems concerning as regulators managing

Язык: Английский

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Cloning, Expression, and Functional Characterization of Two Highly Efficient Flavonoid-di-O-glycosyltransferases ZmUGT84A1 and ZmUGT84A2 from Maize (Zea mays L.)

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(13), С. 7354 - 7363

Опубликована: Март 21, 2024

The maize (Zea mays L.) glycosyltransferase family 1 comprises many uridine diphosphate (UGT) members. However, UGT activities and biochemical functions have seldom been revealed. In this study, the genes of two flavonoid di-O-glycosyltransferases ZmUGT84A1 ZmUGT84A2 were cloned from plant expressed in Escherichia coli. Phylogenetic analysis showed that enzymes homologous to AtUGT84A1 AtUGT84A3. recombinant a high conversion rate luteolin its glucosides, mainly 4′,7-di-O-glucoside minorly 3′,7-di-O-glucoside two-step glycosylation reactions vitro. Moreover, had broad substrate spectrum, converting eriodictyol, naringenin, apigenin, quercetin, kaempferol monoglucosides diglucosides. highly efficient may be used as tool for effective synthesis various O-glycosides markers crop breeding increase O-glycosyl content food.

Язык: Английский

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Ferroptosis: Potential opportunities for natural products in cancer therapy

Phytotherapy Research, Год журнала: 2023, Номер 38(3), С. 1173 - 1190

Опубликована: Дек. 20, 2023

Abstract Cancer cells often exhibit defects in the execution of cell death, resulting poor clinical outcomes for patients with many cancer types. Ferroptosis is a newly discovered form programmed death characterized by intracellular iron overload and lipid peroxidation membrane. Increasing evidence suggests that ferroptosis closely associated wide variety physiological pathological processes, particularly cancer. Notably, various bioactive natural products have been shown to induce initiation cells, thereby exerting anticancer effects. In this review, we summarize core regulatory mechanisms multifaceted roles Importantly, focus on regulate such as terpenoids, polyphenols, alkaloids, steroids, quinones, polysaccharides. The efficacy, adverse effects, drug–drug interactions these need be evaluated further high‐quality studies accelerate their application treatment.

Язык: Английский

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Licochalcone A mitigates aflatoxin B1-induced immunotoxicity via ferroptosis in bursa of broilers and macrophages

Poultry Science, Год журнала: 2024, Номер 103(10), С. 104080 - 104080

Опубликована: Июль 10, 2024

Aflatoxin B

Язык: Английский

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A new strategy for the treatment of intracerebral hemorrhage: Ferroptosis

Experimental Neurology, Год журнала: 2024, Номер 382, С. 114961 - 114961

Опубликована: Сен. 15, 2024

Язык: Английский

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