Toward improved human health: Ferroptosis‐related “Hyperfoods” as the nutritional supplement in COVID‐19 DOI Creative Commons
Yanan Zhao, Hui Cao,

Linyin Ma

и другие.

eFood, Год журнала: 2024, Номер 5(5)

Опубликована: Сен. 19, 2024

Abstract The outbreak of coronavirus disease 2019 (COVID‐19) stimulates a body studies for better investigating the essential mechanisms and clinical characteristics this disease. Notwithstanding, underlying multiple organ failure (MOF) remain unclear. Understanding mechanism COVID‐19‐stimulated programmed cell death (RCD) may contribute to strategies these patients. Based on exploration COVID‐19‐related basic science reports research, we speculate that ferroptosis, recently identified RCD, might be substantial stimulator MOF in COVID‐19, it act as novel treatment target. However, published investigations determine how ferroptosis works severe acute respiratory syndrome 2 infection are still lacking. This review reveals new crucial missing links our prevailing understanding ferroptosis‐triggered COVID‐19 We also specifically summarize several literatures evidence about functional food components nutritional supplement by its inhibition. hope hypothesis launch wave unveil relationship between explore more ferroptosis‐related daily life preventing and/or improve outcome during therapy.

Язык: Английский

Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus DOI
Kun Wang, Xu Shi, Hongjin Lin

и другие.

Journal of Environmental Sciences, Год журнала: 2024, Номер 148, С. 13 - 26

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

5
Natural flavonoids act as potent ferroptosis inhibitors and their potentials in the treatment of ferroptosis-associated diseases DOI Creative Commons
Lu Liu, Lun Wang,

Ying Xiao

и другие.

Pharmacological Research - Modern Chinese Medicine, Год журнала: 2024, Номер 10, С. 100377 - 100377

Опубликована: Янв. 26, 2024

Ferroptosis, an iron-dependent cell death characterized by lethal lipid peroxidation, has been involved in the pathogenesis of various diseases, such as ischemia/reperfusion injury, neurodegenerative and inflammatory disorders. Pharmacological inhibition ferroptosis represents a promising strategy for treatment above diseases. Flavonoids, class natural products found medicinal plants functional foods, are known numerous activities, especially newly discovered anti-ferroptotic activity. Our review aims to expand our understanding flavonoids' activity on multiple biological systems highlight importance utilizing flavonoids ferroptosis-associated A systematic literature search was conducted using Google Scholar, PubMed, Web Science, ScienceDirect, Springer Link. The following keywords: flavonoids, products, ferroptosis, mechanism, available information comprehensively studied compiled. We recent advances molecular mechanisms its roles diverse further systematically summarize inhibitory underlying suggest that ROS accumulation labile Fe2+ availability well activation Nrf2 signaling responsible inhibition. also discuss their clinical applications ferroptosis-related Taken together, exhibit prospect This is expected not only facilitate design development flavonoid-based inhibitors, but diseases therapies.

Язык: Английский

Процитировано

5
Ferroptosis in Liver Disease: Natural Active Compounds and Therapeutic Implications DOI Creative Commons

Zhili Wu,

Yanru Zhu,

Wen‐Chao Liu

и другие.

Antioxidants, Год журнала: 2024, Номер 13(3), С. 352 - 352

Опубликована: Март 15, 2024

Ferroptosis is an emerging type of regulated cell death usually accompanied by the accumulation ferrous ions (Fe2+) and lipid peroxides. As metabolic hub body, liver crucial for iron storage metabolism. The seems to be closely related ferroptosis through Liver disease greatly threatens host health, exploring effective interventions essential. Mounting studies have demonstrated that one possible pathogenic mechanisms involved in disease. Targeting may provide a promising opportunity treating However, drugs targeting are extremely limited. Therefore, it urgent need develop new safe regulators. Natural active compounds (NAC), especially those derived from traditional Chinese medicine, recently shown great therapeutic potential via modulating ferroptosis-related genes or pathways. Here, we outline molecular mechanism systematically summarize regulatory function NAC on Finally, discuss application prospects problems concerning as regulators managing

Язык: Английский

Процитировано

5
Mechanism of evodiamine blocking Nrf2/MAPK pathway to inhibit apoptosis of grass carp hepatocytes induced by DEHP DOI

Yutian Lei,

Wenyue Zhang,

Meichen Gao

и другие.

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2022, Номер 263, С. 109506 - 109506

Опубликована: Ноя. 8, 2022

Язык: Английский

Процитировано

19
Insights into the pharmacological and therapeutic effects of apigenin in liver injuries and diseases DOI Creative Commons

Chenchen Bi,

Wenwen Han, Jingru Yu

и другие.

Heliyon, Год журнала: 2023, Номер 9(5), С. e15609 - e15609

Опубликована: Апрель 20, 2023

Liver diseases are a spectrum of that include hepatic steatosis, nonalcoholic fatty liver disease, hepatitis, fibrosis, cirrhosis, and cancer. These not only severely decrease the quality life for patients, but also cause financial burden. Although apigenin (APG) has recently become primary treatment injuries (LIADs), there been no systematic review its use. To existing literature put forward novel strategies future APG research on LIADs. A search was conducted in PubMed, Science Direct, Research Gate, Web Science, VIP, Wanfang, CNKI, 809 articles were obtained. After applying inclusion exclusion criteria, 135 included. is promising treating LIADs via various mechanisms arising from anti-inflammation, anti-proliferation, anti-infection, anti-oxidation, anti-cancer properties. This summarizes evidence supporting use as provides an insight into intestinal microbiota, which may have important implications clinical

Язык: Английский

Процитировано

11
Apigenin as an emerging hepatoprotective agent: current status and future perspectives DOI Creative Commons
Cheng Wang, Xiaoli Feng, Wen Li

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Дек. 19, 2024

Apigenin (C

Язык: Английский

Процитировано

4
Di-(2-ethylhexyl) phthalate exposure induces liver injury by promoting ferroptosis via downregulation of GPX4 in pregnant mice DOI Creative Commons
Fan Zhang,

Hualong Zhen,

Hengshun Cheng

и другие.

Frontiers in Cell and Developmental Biology, Год журнала: 2022, Номер 10

Опубликована: Ноя. 10, 2022

As one kind of endocrine disrupting chemical, di-(2-ethylhexyl) phthalate (DEHP) has been reported to cause liver dysfunction in epidemiological and experimental studies. Abnormal function pregnancy is associated with adverse maternal perinatal outcomes. Few studies have investigated the potential effect gestational DEHP exposure on pregnant mice, underlying mechanisms remain unclear. In present study, ICR mice were exposed doses (0, 500, 1,000 mg/kg/day) presence or absence 5 mg/kg/day ferrostatin-1 (Fer-1, ferroptosis inhibitor) by oral gavage from gestation day 4 18. HepG2 cells different monoethylhexyl (MEHP, a major metabolite DEHP) vitro . Hepatic pathologic changes observed. Oxidative stress, iron metabolism, ferroptosis-related indicators genes evaluated both vivo The results showed that induced disordered hepatocyte morphology along increased malondialdehyde (MDA) Fe 2+ content decreased glutathione (GSH) levels. expression levels selected Slc7a11 , Gpx4 Nfr2 significantly decreased, Ptgs2 Lpcat3 increased. Notably, Fer-1 attenuated DEHP-induced injury ferroptosis. Furthermore, MEHP exhibited synergistic RSL3 (a GPX4 promoting Taken together, demonstrated probably inhibiting pathway through lipid peroxidation accumulation.

Язык: Английский

Процитировано

15
Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles DOI Creative Commons

Lovy Singh,

Rashmi Pandey, Nikhat J. Siddiqi

и другие.

Toxics, Год журнала: 2025, Номер 13(1), С. 32 - 32

Опубликована: Янв. 2, 2025

Phthalates are the emerging environmental toxicants derived from phthalic acid and its constituents, which moderately present in plastics many personal care products. Phthalate exposure occurs through various factors, including air, water, soil, with absorption facilitated via ingestion, inhalation, dermal contact. Upon exposure, phthalates become bioavailable within biological systems undergo biotransformation detoxification processes liver. The physicochemical properties of indicate their lipophilicity, persistence, bioaccumulation potential, influencing absorption, distribution, hepatic biotransformation. prolonged to adversely influences redox system by altering levels enzymatic non-enzymatic antioxidants, molecular signaling pathways, causing pathogenesis. strategies combat phthalate-induced toxicity include avoiding these compounds using plant-based bioactive molecules such as polyphenols, possess therapeutic potential suppress inflammatory cascades, prevent oxidative damage, stabilize cellular integrity. This review presents a comprehensive updated account chemical, biochemical, immunological, toxicological phthalates, along novel mitigate adverse effects on living systems.

Язык: Английский

Процитировано

0
Combined BPA and DIBP Exposure Induced Intestinal Mucosal Barrier Impairment Through the Notch Pathway and Gut Microbiota Dysbiosis in Mice DOI Creative Commons
Minghui Duan, Yuting Wang, Shiyu Chen

и другие.

Foods, Год журнала: 2025, Номер 14(2), С. 214 - 214

Опубликована: Янв. 12, 2025

Bisphenol A (BPA) and diisobutyl (DIBP) phthalate are widely used as typical plasticizers in food packaging. Plasticizers can be released from polymers, migrate into food, ingested by humans, leading to various health problems. However, little research has investigated the combined toxicity of BPA DIBP, particularly their intestinal toxicity. Our goal is analyse (50 mg/kg) DIBP (500 on intestines KM mice. Additionally, we tried find natural products that inhibit or prevent DIBP. The results indicated combination exposure resulted a reduction beneficial flora, an increase D-Lac levels (136 ± 14 μmol/L), permeability, activation notch pathway, decline stem cells (ISCs) goblet cells, compared single-exposure sources. Nevertheless, Rubus chingii Hu phenolic extract (RHPE) (200, 400 600 ameliorated DIBP-induced microbiota disruption mucosal barrier impairment inhibiting overactivation pathway. this study highlight potential risks human posed may help explain pathways enterotoxicity caused ingestion.

Язык: Английский

Процитировано

0
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases DOI Creative Commons

Rachid Kacemi,

María G. Campos

Antioxidants, Год журнала: 2025, Номер 14(3), С. 265 - 265

Опубликована: Фев. 25, 2025

Bee pollen (BP) is one of the richest known natural resources micronutrients and bioactive phytochemicals. Some captivating bioactivities BP compounds, although being largely investigated for latter as individual molecules, remain very scarcely or completely uninvestigated in bee a whole product. Among most intriguing these bioactivities, we identified ferroptosis major one. Ferroptosis, recently discovered form cell death (connecting oxidative stress inflammation), complex pathophysiological process crucial perplexing events current challenging human diseases such cancer, neurodegeneration, general aging diseases. Many compounds were found to intricately modulate depending on cellular context by inducing this mechanism malignant cells preventing it non-malignant cells. Since research both fields, i.e., ferroptosis, still recent, deemed necessary undertake review figure out extent potential modulating mechanisms. Our proved that wide range (polyphenols, phenolamides, carotenoids, vitamins, minerals, others) substantially diverse Accordingly, phytochemicals nutrients showed interesting preclinical studies lead ferroptosis-mediated outcomes important processes, including many aging-related disorders. One paramount challenges be resolved determine how different act biological contexts, either through synergistic antagonistic behaviors. We hope our work constitutes valuable incentive future investigations promising relevant avenue.

Язык: Английский

Процитировано

0