Abstract
The
outbreak
of
coronavirus
disease
2019
(COVID‐19)
stimulates
a
body
studies
for
better
investigating
the
essential
mechanisms
and
clinical
characteristics
this
disease.
Notwithstanding,
underlying
multiple
organ
failure
(MOF)
remain
unclear.
Understanding
mechanism
COVID‐19‐stimulated
programmed
cell
death
(RCD)
may
contribute
to
strategies
these
patients.
Based
on
exploration
COVID‐19‐related
basic
science
reports
research,
we
speculate
that
ferroptosis,
recently
identified
RCD,
might
be
substantial
stimulator
MOF
in
COVID‐19,
it
act
as
novel
treatment
target.
However,
published
investigations
determine
how
ferroptosis
works
severe
acute
respiratory
syndrome
2
infection
are
still
lacking.
This
review
reveals
new
crucial
missing
links
our
prevailing
understanding
ferroptosis‐triggered
COVID‐19
We
also
specifically
summarize
several
literatures
evidence
about
functional
food
components
nutritional
supplement
by
its
inhibition.
hope
hypothesis
launch
wave
unveil
relationship
between
explore
more
ferroptosis‐related
daily
life
preventing
and/or
improve
outcome
during
therapy.
Pharmacological Research - Modern Chinese Medicine,
Год журнала:
2024,
Номер
10, С. 100377 - 100377
Опубликована: Янв. 26, 2024
Ferroptosis,
an
iron-dependent
cell
death
characterized
by
lethal
lipid
peroxidation,
has
been
involved
in
the
pathogenesis
of
various
diseases,
such
as
ischemia/reperfusion
injury,
neurodegenerative
and
inflammatory
disorders.
Pharmacological
inhibition
ferroptosis
represents
a
promising
strategy
for
treatment
above
diseases.
Flavonoids,
class
natural
products
found
medicinal
plants
functional
foods,
are
known
numerous
activities,
especially
newly
discovered
anti-ferroptotic
activity.
Our
review
aims
to
expand
our
understanding
flavonoids'
activity
on
multiple
biological
systems
highlight
importance
utilizing
flavonoids
ferroptosis-associated
A
systematic
literature
search
was
conducted
using
Google
Scholar,
PubMed,
Web
Science,
ScienceDirect,
Springer
Link.
The
following
keywords:
flavonoids,
products,
ferroptosis,
mechanism,
available
information
comprehensively
studied
compiled.
We
recent
advances
molecular
mechanisms
its
roles
diverse
further
systematically
summarize
inhibitory
underlying
suggest
that
ROS
accumulation
labile
Fe2+
availability
well
activation
Nrf2
signaling
responsible
inhibition.
also
discuss
their
clinical
applications
ferroptosis-related
Taken
together,
exhibit
prospect
This
is
expected
not
only
facilitate
design
development
flavonoid-based
inhibitors,
but
diseases
therapies.
Antioxidants,
Год журнала:
2024,
Номер
13(3), С. 352 - 352
Опубликована: Март 15, 2024
Ferroptosis
is
an
emerging
type
of
regulated
cell
death
usually
accompanied
by
the
accumulation
ferrous
ions
(Fe2+)
and
lipid
peroxides.
As
metabolic
hub
body,
liver
crucial
for
iron
storage
metabolism.
The
seems
to
be
closely
related
ferroptosis
through
Liver
disease
greatly
threatens
host
health,
exploring
effective
interventions
essential.
Mounting
studies
have
demonstrated
that
one
possible
pathogenic
mechanisms
involved
in
disease.
Targeting
may
provide
a
promising
opportunity
treating
However,
drugs
targeting
are
extremely
limited.
Therefore,
it
urgent
need
develop
new
safe
regulators.
Natural
active
compounds
(NAC),
especially
those
derived
from
traditional
Chinese
medicine,
recently
shown
great
therapeutic
potential
via
modulating
ferroptosis-related
genes
or
pathways.
Here,
we
outline
molecular
mechanism
systematically
summarize
regulatory
function
NAC
on
Finally,
discuss
application
prospects
problems
concerning
as
regulators
managing
Heliyon,
Год журнала:
2023,
Номер
9(5), С. e15609 - e15609
Опубликована: Апрель 20, 2023
Liver
diseases
are
a
spectrum
of
that
include
hepatic
steatosis,
nonalcoholic
fatty
liver
disease,
hepatitis,
fibrosis,
cirrhosis,
and
cancer.
These
not
only
severely
decrease
the
quality
life
for
patients,
but
also
cause
financial
burden.
Although
apigenin
(APG)
has
recently
become
primary
treatment
injuries
(LIADs),
there
been
no
systematic
review
its
use.
To
existing
literature
put
forward
novel
strategies
future
APG
research
on
LIADs.
A
search
was
conducted
in
PubMed,
Science
Direct,
Research
Gate,
Web
Science,
VIP,
Wanfang,
CNKI,
809
articles
were
obtained.
After
applying
inclusion
exclusion
criteria,
135
included.
is
promising
treating
LIADs
via
various
mechanisms
arising
from
anti-inflammation,
anti-proliferation,
anti-infection,
anti-oxidation,
anti-cancer
properties.
This
summarizes
evidence
supporting
use
as
provides
an
insight
into
intestinal
microbiota,
which
may
have
important
implications
clinical
Frontiers in Cell and Developmental Biology,
Год журнала:
2022,
Номер
10
Опубликована: Ноя. 10, 2022
As
one
kind
of
endocrine
disrupting
chemical,
di-(2-ethylhexyl)
phthalate
(DEHP)
has
been
reported
to
cause
liver
dysfunction
in
epidemiological
and
experimental
studies.
Abnormal
function
pregnancy
is
associated
with
adverse
maternal
perinatal
outcomes.
Few
studies
have
investigated
the
potential
effect
gestational
DEHP
exposure
on
pregnant
mice,
underlying
mechanisms
remain
unclear.
In
present
study,
ICR
mice
were
exposed
doses
(0,
500,
1,000
mg/kg/day)
presence
or
absence
5
mg/kg/day
ferrostatin-1
(Fer-1,
ferroptosis
inhibitor)
by
oral
gavage
from
gestation
day
4
18.
HepG2
cells
different
monoethylhexyl
(MEHP,
a
major
metabolite
DEHP)
vitro
.
Hepatic
pathologic
changes
observed.
Oxidative
stress,
iron
metabolism,
ferroptosis-related
indicators
genes
evaluated
both
vivo
The
results
showed
that
induced
disordered
hepatocyte
morphology
along
increased
malondialdehyde
(MDA)
Fe
2+
content
decreased
glutathione
(GSH)
levels.
expression
levels
selected
Slc7a11
,
Gpx4
Nfr2
significantly
decreased,
Ptgs2
Lpcat3
increased.
Notably,
Fer-1
attenuated
DEHP-induced
injury
ferroptosis.
Furthermore,
MEHP
exhibited
synergistic
RSL3
(a
GPX4
promoting
Taken
together,
demonstrated
probably
inhibiting
pathway
through
lipid
peroxidation
accumulation.
Toxics,
Год журнала:
2025,
Номер
13(1), С. 32 - 32
Опубликована: Янв. 2, 2025
Phthalates
are
the
emerging
environmental
toxicants
derived
from
phthalic
acid
and
its
constituents,
which
moderately
present
in
plastics
many
personal
care
products.
Phthalate
exposure
occurs
through
various
factors,
including
air,
water,
soil,
with
absorption
facilitated
via
ingestion,
inhalation,
dermal
contact.
Upon
exposure,
phthalates
become
bioavailable
within
biological
systems
undergo
biotransformation
detoxification
processes
liver.
The
physicochemical
properties
of
indicate
their
lipophilicity,
persistence,
bioaccumulation
potential,
influencing
absorption,
distribution,
hepatic
biotransformation.
prolonged
to
adversely
influences
redox
system
by
altering
levels
enzymatic
non-enzymatic
antioxidants,
molecular
signaling
pathways,
causing
pathogenesis.
strategies
combat
phthalate-induced
toxicity
include
avoiding
these
compounds
using
plant-based
bioactive
molecules
such
as
polyphenols,
possess
therapeutic
potential
suppress
inflammatory
cascades,
prevent
oxidative
damage,
stabilize
cellular
integrity.
This
review
presents
a
comprehensive
updated
account
chemical,
biochemical,
immunological,
toxicological
phthalates,
along
novel
mitigate
adverse
effects
on
living
systems.
Foods,
Год журнала:
2025,
Номер
14(2), С. 214 - 214
Опубликована: Янв. 12, 2025
Bisphenol
A
(BPA)
and
diisobutyl
(DIBP)
phthalate
are
widely
used
as
typical
plasticizers
in
food
packaging.
Plasticizers
can
be
released
from
polymers,
migrate
into
food,
ingested
by
humans,
leading
to
various
health
problems.
However,
little
research
has
investigated
the
combined
toxicity
of
BPA
DIBP,
particularly
their
intestinal
toxicity.
Our
goal
is
analyse
(50
mg/kg)
DIBP
(500
on
intestines
KM
mice.
Additionally,
we
tried
find
natural
products
that
inhibit
or
prevent
DIBP.
The
results
indicated
combination
exposure
resulted
a
reduction
beneficial
flora,
an
increase
D-Lac
levels
(136
±
14
μmol/L),
permeability,
activation
notch
pathway,
decline
stem
cells
(ISCs)
goblet
cells,
compared
single-exposure
sources.
Nevertheless,
Rubus
chingii
Hu
phenolic
extract
(RHPE)
(200,
400
600
ameliorated
DIBP-induced
microbiota
disruption
mucosal
barrier
impairment
inhibiting
overactivation
pathway.
this
study
highlight
potential
risks
human
posed
may
help
explain
pathways
enterotoxicity
caused
ingestion.
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 265 - 265
Опубликована: Фев. 25, 2025
Bee
pollen
(BP)
is
one
of
the
richest
known
natural
resources
micronutrients
and
bioactive
phytochemicals.
Some
captivating
bioactivities
BP
compounds,
although
being
largely
investigated
for
latter
as
individual
molecules,
remain
very
scarcely
or
completely
uninvestigated
in
bee
a
whole
product.
Among
most
intriguing
these
bioactivities,
we
identified
ferroptosis
major
one.
Ferroptosis,
recently
discovered
form
cell
death
(connecting
oxidative
stress
inflammation),
complex
pathophysiological
process
crucial
perplexing
events
current
challenging
human
diseases
such
cancer,
neurodegeneration,
general
aging
diseases.
Many
compounds
were
found
to
intricately
modulate
depending
on
cellular
context
by
inducing
this
mechanism
malignant
cells
preventing
it
non-malignant
cells.
Since
research
both
fields,
i.e.,
ferroptosis,
still
recent,
deemed
necessary
undertake
review
figure
out
extent
potential
modulating
mechanisms.
Our
proved
that
wide
range
(polyphenols,
phenolamides,
carotenoids,
vitamins,
minerals,
others)
substantially
diverse
Accordingly,
phytochemicals
nutrients
showed
interesting
preclinical
studies
lead
ferroptosis-mediated
outcomes
important
processes,
including
many
aging-related
disorders.
One
paramount
challenges
be
resolved
determine
how
different
act
biological
contexts,
either
through
synergistic
antagonistic
behaviors.
We
hope
our
work
constitutes
valuable
incentive
future
investigations
promising
relevant
avenue.