EGR1 knockdown confers protection against ferroptosis and ameliorates intervertebral disc cartilage degeneration by inactivating the MAP3K14/NF-κB axis DOI Creative Commons
Jian‐Guo Zhang,

Liming He,

Qiang Li

и другие.

Genomics, Год журнала: 2023, Номер 115(5), С. 110683 - 110683

Опубликована: Июль 13, 2023

This study explored whether EGR1-MAP3K14-NF-κB axis regulated ferroptosis and IVD cartilage generation. EGR1 MAP3K14 expression levels were determined in CEP tissues of IVDD patients intermittent cyclic mechanical tension (ICMT)-treated cells. After altered ICMT-treated cells, the degeneration- ferroptosis-related proteins measured. Binding relationship between was evaluated. Additionally, impacts EFR1 knockdown on degeneration vivo analyzed. overexpressed clinical samples cell models IVDD. In models, reduced degeneration, which reversed by overexpression or Erastin treatment. NF-κB pathway inhibition nullified these effects sh-EGR1 + oe-MAP3K14 inhibited relieved via MAP3K14-NF-κB inactivation vivo. Collectively, our findings highlighted that promoted through axis.

Язык: Английский

Magnesium Gradient‐Based Hierarchical Scaffold for Dual‐Lineage Regeneration of Osteochondral Defect DOI
Chenyuan Gao, Wenli Dai, Xinyu Wang

и другие.

Advanced Functional Materials, Год журнала: 2023, Номер 33(43)

Опубликована: Июль 2, 2023

Abstract Osteochondral regeneration remains a great challenge due to the limited self‐healing ability and complexity of its hierarchical structure composition. Mg 2+ hypoxia are two effective modulators in boosting chondrogenesis. To this end, double‐layered scaffold (D) consisting hydrogel layer on porous cryogel is fabricated mimic osteochondral tissue. An gradient incorporated into with hypoxia‐mimicking deferoxamine (DFO) embedded (D‐Mg‐DFO), which remarkably augments dual‐lineage both cartilage subchondral bone. The higher supplementation from upper hydrogel, associated situation small pore size, exhibits promotive effects chondrogenic differentiation. lower bottom cryogel, interconnected macroporous structure, achieves multiple contributions stem cell migration bone marrow cavity, matrix mineralization, osteogenesis. Furthermore, rabbits’ trochlea defects established evaluate regenerative outcome. Compared control scaffolds containing only or DFO, D‐Mg‐DFO presents best effect under synergistic contribution factors. Overall, work provides new design toward an repair defect.

Язык: Английский

Процитировано

61
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Язык: Английский

Процитировано

42
Ferroptosis inhibitors: past, present and future DOI Creative Commons
Lei Zhang, Yi Luo, Yang Xiang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Язык: Английский

Процитировано

17
Mechanisms of chondrocyte regulated cell death in osteoarthritis: Focus on ROS-triggered ferroptosis, parthanatos, and oxeiptosis DOI

Fangyang Fan,

Cheng Yang,

Enran Piao

и другие.

Biochemical and Biophysical Research Communications, Год журнала: 2024, Номер 705, С. 149733 - 149733

Опубликована: Фев. 28, 2024

Язык: Английский

Процитировано

8
Advances in research on immunocyte iron metabolism, ferroptosis, and their regulatory roles in autoimmune and autoinflammatory diseases DOI Creative Commons

Liuting Zeng,

Kailin Yang,

Ganpeng Yu

и другие.

Cell Death and Disease, Год журнала: 2024, Номер 15(7)

Опубликована: Июль 4, 2024

Abstract Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis remain unclear. Currently, increasing research has highlighted the role of ferroptosis in immune regulation, with cells being a crucial component body’s system. This review provides an overview discusses relationship between ferroptosis, programmed cell death cells, autoimmune diseases. Additionally, it summarizes key targets such as GPX4 TFR, responses. Furthermore, release multiple molecules, including damage-associated molecular patterns (DAMPs), following by is examined, these molecules further influence differentiation function thereby affecting occurrence progression Moreover, secrete factors or metabolites, which also impact target organs tissues involved Iron chelators, chloroquine its derivatives, antioxidants, calreticulin have been demonstrated to be effective animal studies for certain diseases, exerting anti-inflammatory immunomodulatory effects. Finally, brief summary future perspectives on are provided, aiming guide disease treatment strategies.

Язык: Английский

Процитировано

8
Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives DOI Creative Commons
Hao Chen, Zhongyu Han, Yi Wang

и другие.

Journal of Inflammation Research, Год журнала: 2023, Номер Volume 16, С. 4661 - 4677

Опубликована: Окт. 1, 2023

Abstract: Ferroptosis is a new cell fate decision discovered in recent years. Unlike apoptosis, autophagy or pyroptosis, ferroptosis characterized by iron-dependent lipid peroxidation and mitochondrial morphological changes. involved variety of physiological pathological processes. Since its discovery, has been increasingly studied concerning bone-related diseases. In this review, we focus on the latest research progress prospects, summarize regulatory mechanisms ferroptosis, discuss role pathogenesis diseases, such as osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), well therapeutic potential. Keywords: death, iron accumulation, peroxidation, diseases

Язык: Английский

Процитировано

20
The role of mitochondrial quality control mechanisms in chondrocyte senescence DOI Creative Commons

Tianlei Zhao,

Dawei Niu,

Yancheng Chen

и другие.

Experimental Gerontology, Год журнала: 2024, Номер 188, С. 112379 - 112379

Опубликована: Фев. 27, 2024

Chondrocytes are the exclusive cellular constituents of articular cartilage, and their functional status governs health cartilage. The primary factor contributing to deterioration cartilage structure function is chondrocyte senescence. In hypoxia hypodextrose environment, chondrocytes heavily rely on glycolysis for energy metabolism. Mitochondria, acting as regulatory hub metabolism, exhibit dysfunction before senescence, indicating crucial involvement in process. Previous research has suggested that molecules associated with mitochondrial quality control mechanisms can effectively restore alleviate However, there remains be clarity regarding relationship between differences efficacy among various target molecules, which pose challenges when evaluating them chondrocytes. By conducting a comprehensive review existing literature we gain further insights into this intricate while identifying promising targets could potentially open up novel avenues treatment

Язык: Английский

Процитировано

7
LncRNA MEG3 suppresses erastin-induced ferroptosis of chondrocytes via regulating miR-885-5p/SLC7A11 axis DOI

Chongtao Zhu,

Bin Chen, He Xu

и другие.

Molecular Biology Reports, Год журнала: 2024, Номер 51(1)

Опубликована: Янв. 18, 2024

Язык: Английский

Процитировано

6
Crosstalk between ferroptosis and chondrocytes in osteoarthritis: a systematic review of in vivo and in vitro studies DOI Creative Commons
Siyang Cao, Yihao Wei,

Huihui Xu

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Июль 14, 2023

Purpose Recent scientific reports have revealed a close association between ferroptosis and the occurrence development of osteoarthritis (OA). Nevertheless, precise mechanisms by which influences OA how to hobble progression inhibiting chondrocyte not yet been fully elucidated. This study aims conduct comprehensive systematic review (SR) address these gaps. Methods Following guidelines Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) 2020, we conducted search Embase, Ovid, ProQuest, PubMed, Scopus, Cochrane Library, Web Science databases identify relevant studies that investigate chondrocytes in OA. Our included published from inception until January 31st, 2023. Only met predetermined quality criteria were this SR. Results In SR, total 21 specified considered suitable current updated synthesis. The underlying its with involve various biological phenomena, including mitochondrial dysfunction, dysregulated iron metabolism, oxidative stress, crucial signaling pathways. Conclusion Ferroptosis has opened an entirely new chapter investigation OA, targeted regulation it is springing up as attractive promising therapeutic tactic registration https://inplasy.com/inplasy-2023-3-0044/ , identifier INPLASY202330044.

Язык: Английский

Процитировано

15
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review DOI Creative Commons
Nemanja Živanović, Marija Lesjak, Nataša Simin

и другие.

Antioxidants, Год журнала: 2024, Номер 13(3), С. 334 - 334

Опубликована: Март 10, 2024

Ferroptosis is a recently discovered type of programmed cell death that mechanistically different from other types such as apoptosis, necroptosis, and autophagy. It characterized by the accumulation intracellular iron, overproduction reactive oxygen species, depletion glutathione, extensive lipid peroxidation lipids in membrane. was ferroptosis interconnected with many diseases, neurodegenerative ischemia/reperfusion injury, cancer, chronic kidney disease. Polyphenols, plant secondary metabolites known for bioactivities, are being extensively researched context their influence on which resulted great number publications showing need systematic review. In this review, an literature search performed. Databases (Scopus, Web Science, PubMed, ScienceDirect, Springer) were searched time span 2017 to November 2023, using keyword “ferroptosis” alone combination “flavonoid”, “phenolic acid”, “stilbene”, “coumarin”, “anthraquinone”, “chalcone”; after selection studies, we had 311 papers 143 phenolic compounds. total, 53 compounds showed ability induce ferroptosis, 110 able inhibit out those compounds, 20 both abilities depending model system. The most shikonin, curcumin, quercetin, resveratrol, baicalin. common modes action modulation Nrf2/GPX4 Nrf2/HO-1 axis iron metabolism.

Язык: Английский

Процитировано

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