Coatings,
Год журнала:
2025,
Номер
15(1), С. 105 - 105
Опубликована: Янв. 18, 2025
In
this
study,
chitosan
(CH)
was
loaded
with
spearmint
(S)
essential
oil
nanoemulsion
(EO)
to
provide
antifungal
properties
during
the
postharvest
storage
of
soft
citrus
fruits.
(S)-EO
(2%)
nanoemulsion–CH
(0.8%)
coatings
inhibited
100%
Penicillium
italicum
and
digitatum
radial
mycelial
growth
spore
germination
in
vitro.
The
coating
enhanced
activity
by
achieving
inhibition
P.
cultivars
‘Nova’
‘Tango’
compared
control
vivo.
However,
decay
reduced
33%
18%
control.
(2%)-CH
system
prepared
high
shear
homogenization
showed
a
particle
size
252.3
nm
zeta
potential
+21.6
mV,
indicating
changes
molecular
interactions
structural
reorganization
between
EO
CH.
polydispersity
index
values
indicated
stable
system.
pH
remained
acidic,
favored,
incorporation
improved
thermal
stability
CH
coating.
optical
less
transparency
more
opacity.
Despite
cultivar
differences
affecting
host
specificity,
study
recommends
using
2%
(S)EO
instead
synthetic
chemicals
extend
fruit
life.
Chitosan
nanoparticles
(NPs)
are
well-recognized
as
promising
vehicles
for
delivering
anticancer
drugs
due
to
their
distinctive
characteristics.
They
have
the
potential
enclose
hydrophobic
molecules,
thereby
enhancing
solubilities,
permeabilities,
and
bioavailabilities;
without
use
of
surfactant,
i.e.,
through
surfactant-free
solubilization.
This
allows
higher
drug
concentrations
at
tumor
sites,
prevents
excessive
toxicity
imparted
by
surfactants,
could
circumvent
resistance.
Moreover,
biomedical
engineers
formulation
scientists
can
also
fabricate
chitosan
NPs
slowly
release
agents.
keeps
site
longer,
makes
therapy
more
effective,
lowers
frequency
dosing.
Notably,
some
types
cancer
cells
(fallopian
tube,
epithelial
tumors
ovary,
primary
peritoneum;
lung,
kidney,
ependymal
brain,
uterus,
breast,
colon,
malignant
pleural
mesothelioma)
overexpression
folate
receptors
(FRs)
on
outer
surface,
which
lets
folate-drug
conjugate–incorporated
target
kill
them
effectively.
Strikingly,
there
is
evidence
suggesting
that
excessively
produced
FR&αgr
(isoforms
FR)
stays
consistent
throughout
treatment
in
ovarian
endometrial
cancer,
indicating
resistance
conventional
treatment;
this
regard,
folate-anchored
overcome
it
improve
therapeutic
outcomes.
Interestingly,
overly
expressed
FRs
present
only
certain
types,
a
biomarker
predicting
effectiveness
FR-targeted
therapy.
On
other
hand,
folate-modified
enhance
oral
absorption
medicines,
especially
drugs,
pave
way
effective
long-term
low-dose
metronomic
scheduling
poorly
soluble
permeable
drugs.
In
review,
we
talked
briefly
about
techniques
used
create,
characterize,
tailor
chitosan-based
NPs;
delved
deeper
into
applications
folate-engineered
treating
various
types.
Schematic
illustration
ligand-drug
incorporated
its
advantage
cancer.
Figure
created
with
BioRender.Com.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 17, 2025
The
g-C3N4/CS
biosensor
was
designed,
fabricated,
and
tested
using
compounds
such
as
glucose,
urine,
lactose,
flutamide
at
a
molarity
of
10
µM,
which
could
demonstrate
high
sensitivity
200
μm-1
for
flutamide.
Powerful
effective
medium
theory
FDTD
simulation
were
used
to
predict
the
most
favorable
mode
plasmonic
properties
graphite
carbon
nitride
chitosan
nanocomposite.
research
also
explores
characteristics
surface
plasmon
resonance
exhibited
by
nanocomposite
content
is
adjusted.
Subsequent
simulations
are
conducted
on
nanocomposites
incorporating
thin
layer
modified
gold
structure.
intricate
ultimately
reveal
optimal
combination,
under
three
different
pH
conditions
(6.2,
7.2,
8).
In
acidic
conditions,
kinetic
profile
yielded
KD=
3.45
×
10−7,
surpassing
KD
value
film.
Au
significantly
outperformed
alternative
material.
demonstrated
linear
behavior
across
wide
concentration
range
from
1
150
achieving
detection
limit
120
nM
with
its
sensitivity.
Journal of Composites Science,
Год журнала:
2025,
Номер
9(3), С. 133 - 133
Опубликована: Март 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
