Lemon-Derived Exosome-Like Nanovesicles: A Promising Avenue for Drug Delivery System and Therapeutic Applications in Biomedical Science
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106474 - 106474
Опубликована: Март 1, 2025
Язык: Английский
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: A review
Expert Opinion on Drug Delivery,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 30, 2025
Introduction
Plant-derived
extracellular
vesicles
(P-EVs)
are
nanoscale,
lipid
bilayer
capable
of
transporting
diverse
bioactive
substances,
enabling
intercellular
and
interspecies
communication
material
transfer.
With
inherent
pharmacological
effects,
targeting
abilities,
high
safety,
biocompatibility,
low
production
costs,
P-EVs
promising
candidates
for
drug
delivery
systems,
offering
significant
application
potential.
Язык: Английский
Plant-Derived Extracellular Vesicles: Natural Nanocarriers for Biotechnological Drugs
Processes,
Год журнала:
2024,
Номер
12(12), С. 2938 - 2938
Опубликована: Дек. 23, 2024
Plant-derived
extracellular
vesicles
(PDEVs)
are
lipid
bilayer
nanoparticles,
naturally
produced
by
plant
cells,
with
sizes
ranging
from
50
to
500
nm.
Recent
studies
have
highlighted
their
great
potential
in
the
biotechnological
and
medical
fields,
due
natural
origin,
high
biocompatibility
intrinsic
therapeutic
properties.
PDEVs
contain
a
complex
biological
cargo
of
proteins,
lipids,
nucleic
acids
secondary
metabolites,
including
antioxidants
anti-inflammatory
molecules,
making
them
ideal
for
biomedical
applications
such
as
drug
delivery.
These
play
key
role
intercellular
communication
gene
regulation,
proving
be
particularly
promising
personalized
medicine.
ability
improve
stability
bioavailability,
optimizing
targeted
release
minimizing
side
effects.
Despite
some
challenges,
compositional
variability
need
standardized
protocols,
at
gunsight
innovative
research
aimed
improving
loading
capacity
specificity.
This
review
aims
provide
comprehensive
overview
PDEVs,
exploring
structure,
isolation
methods,
functional
characteristics,
applications,
highlighting
advantages
over
synthetic
nanoparticles
animal-derived
vesicles,
leading
an
sustainable
solution
development
new
approaches.
Язык: Английский
Recent advances in the development and application of curcumin-loaded micro/nanocarriers in food research
Advances in Colloid and Interface Science,
Год журнала:
2024,
Номер
335, С. 103333 - 103333
Опубликована: Ноя. 4, 2024
Язык: Английский
Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12793 - 12815
Опубликована: Ноя. 1, 2024
Plant-derived
exosome-like
nanovesicles
(PELNs)
from
edible
plants,
isolated
by
ultracentrifugation,
size
exclusion
chromatography
or
other
methods,
were
proved
to
contain
a
variety
of
biologically
active
and
therapeutically
specific
components.
Recently,
investigations
in
the
field
PELN-based
biomedicine
have
been
conducted,
which
positioned
those
as
promising
tools
for
prevention
treatment
several
diseases,
with
their
natural
origin
potentially
offering
superior
biocompatibility
bioavailability.
However,
inadequate
targeting
limited
therapeutic
effects
constrain
utility
clinical
translation
PELNs.
Thus,
strategies
aiming
at
bridging
gap
engineering
PELNs
great
interest.
Those
approaches
include
membrane
hybridization,
physical
chemical
surface
functionalization
encapsulation
payloads.
Herein,
we
provide
comprehensive
overview
biogenesis
composition,
isolation
purification
methods
characterization
PELNs,
well
functions.
Current
knowledge
on
construction
biomedical
application
engineered
reviewed.
Additionally,
future
directions
perspectives
this
discussed
order
further
enrich
expand
prospects
Язык: Английский