Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives DOI Creative Commons
Yuhan Li, Yulong Wang,

Hongrui Zhao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12793 - 12815

Published: Nov. 1, 2024

Plant-derived exosome-like nanovesicles (PELNs) from edible plants, isolated by ultracentrifugation, size exclusion chromatography or other methods, were proved to contain a variety of biologically active and therapeutically specific components. Recently, investigations in the field PELN-based biomedicine have been conducted, which positioned those as promising tools for prevention treatment several diseases, with their natural origin potentially offering superior biocompatibility bioavailability. However, inadequate targeting limited therapeutic effects constrain utility clinical translation PELNs. Thus, strategies aiming at bridging gap engineering PELNs great interest. Those approaches include membrane hybridization, physical chemical surface functionalization encapsulation payloads. Herein, we provide comprehensive overview biogenesis composition, isolation purification methods characterization PELNs, well functions. Current knowledge on construction biomedical application engineered reviewed. Additionally, future directions perspectives this discussed order further enrich expand prospects

Language: Английский

Lemon-Derived Exosome-Like Nanovesicles: A Promising Avenue for Drug Delivery System and Therapeutic Applications in Biomedical Science DOI

Mansi Khadilkar,

Sanchit Arora,

Rohan Chand Sahu

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106474 - 106474

Published: March 1, 2025

Language: Английский

Citations

0
Application of plant-derived extracellular vesicles as novel carriers in drug delivery systems: A review DOI
Jia-Yi Yang, Xinyi Ai, Chenming Zhang

et al.

Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown

Published: March 30, 2025

Introduction Plant-derived extracellular vesicles (P-EVs) are nanoscale, lipid bilayer capable of transporting diverse bioactive substances, enabling intercellular and interspecies communication material transfer. With inherent pharmacological effects, targeting abilities, high safety, biocompatibility, low production costs, P-EVs promising candidates for drug delivery systems, offering significant application potential.

Language: Английский

Citations

0
Plant-Derived Extracellular Vesicles: Natural Nanocarriers for Biotechnological Drugs DOI Open Access
Eleonora Calzoni, Agnese Bertoldi, Gaia Cusumano

et al.

Processes, Journal Year: 2024, Volume and Issue: 12(12), P. 2938 - 2938

Published: Dec. 23, 2024

Plant-derived extracellular vesicles (PDEVs) are lipid bilayer nanoparticles, naturally produced by plant cells, with sizes ranging from 50 to 500 nm. Recent studies have highlighted their great potential in the biotechnological and medical fields, due natural origin, high biocompatibility intrinsic therapeutic properties. PDEVs contain a complex biological cargo of proteins, lipids, nucleic acids secondary metabolites, including antioxidants anti-inflammatory molecules, making them ideal for biomedical applications such as drug delivery. These play key role intercellular communication gene regulation, proving be particularly promising personalized medicine. ability improve stability bioavailability, optimizing targeted release minimizing side effects. Despite some challenges, compositional variability need standardized protocols, at gunsight innovative research aimed improving loading capacity specificity. This review aims provide comprehensive overview PDEVs, exploring structure, isolation methods, functional characteristics, applications, highlighting advantages over synthetic nanoparticles animal-derived vesicles, leading an sustainable solution development new approaches.

Language: Английский

Citations

3
Recent advances in the development and application of curcumin-loaded micro/nanocarriers in food research DOI

Guangyi Kan,

Lijia Chen, Wenjie Zhang

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 335, P. 103333 - 103333

Published: Nov. 4, 2024

Language: Английский

Citations

1
Engineering Strategies of Plant-Derived Exosome-Like Nanovesicles: Current Knowledge and Future Perspectives DOI Creative Commons
Yuhan Li, Yulong Wang,

Hongrui Zhao

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12793 - 12815

Published: Nov. 1, 2024

Plant-derived exosome-like nanovesicles (PELNs) from edible plants, isolated by ultracentrifugation, size exclusion chromatography or other methods, were proved to contain a variety of biologically active and therapeutically specific components. Recently, investigations in the field PELN-based biomedicine have been conducted, which positioned those as promising tools for prevention treatment several diseases, with their natural origin potentially offering superior biocompatibility bioavailability. However, inadequate targeting limited therapeutic effects constrain utility clinical translation PELNs. Thus, strategies aiming at bridging gap engineering PELNs great interest. Those approaches include membrane hybridization, physical chemical surface functionalization encapsulation payloads. Herein, we provide comprehensive overview biogenesis composition, isolation purification methods characterization PELNs, well functions. Current knowledge on construction biomedical application engineered reviewed. Additionally, future directions perspectives this discussed order further enrich expand prospects

Language: Английский

Citations

1